DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3632 and mtmr12

DIOPT Version :9

Sequence 1:	NP_001096996.1	Gene:	CG3632 / 32589	FlyBaseID:	FBgn0030735	Length:	1250	Species:	Drosophila melanogaster
Sequence 2:	XP_009299937.1	Gene:	mtmr12 / 569130	ZFINID:	ZDB-GENE-050401-1	Length:	753	Species:	Danio rerio

Alignment Length:	929	Identity:	205/929 - (22%)
Similarity:	327/929 - (35%)	Gaps:	308/929 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 SPPPSICFIRAAE-SYPKSQMEKEDSQLFVPFQEL---AGESIKYLGRTDD-------GILALSN 67
            |.|..:.::...| ...|...:||.....:|.:.:   |...:||  ..||       |.|..:|
Zfish    12 SKPSFVSYVTPEEIKLEKDPQKKEKHPDLLPGEVVFCSANPILKY--TQDDLSQRGVFGTLLCTN 74

  Fly    68 YRI-FLS------------KQSTGYETYVPLGLIESV-----QVRDLF-----------QLIVNC 103
            :|: |:|            |.....|..:||..::.:     :.|.|.           ::|::|
Zfish    75 FRVAFISDDAPQEEMSKTFKNKLYGENDIPLMCVDHIYGVYDEKRKLITGGLVKNKCPSKMIIHC 139

  Fly   104 KDASTVR-CSFPSAEQCSDWQRRIHLMIGV------PESLETLFAFPFYSWTCDVLGSGNGSGIV 161
            ||....: |...|.|:  |.:|   :..|:      .:||:.:|||.:       |.|.|.....
Zfish   140 KDLRVFQFCLTFSKEE--DAKR---IFQGIAHHCLEEKSLKCVFAFSY-------LRSTNPDHGK 192

  Fly   162 SAQANGNGLIAKDRCLTLHNGLAKPTANVTASNPLPDPASETISAAMSNRLQRSVRYES--DFKN 224
            |::          :|:|                 ..|..||.:      |.:.::.::|  |:..
Zfish   193 SSR----------KCIT-----------------RLDSKSEML------RKREAIMFDSPEDWTQ 224

  Fly   225 EVARLGFDLKGSWRISTANADFKLCPSYPPKLLVPCCITDEMLHNVANFRGSRRLPAVVWRHQKS 289
            |:.|    .|...|:.|.|.:|:|....|...::|..:.|     :.|::| :.||...|.|
Zfish   225 EMKR----TKAQCRLVTENENFELSQRLPQYFVIPSALGD-----LFNYQG-KGLPIWCWSH--- 276

  Fly   290 GAILARCSQPEVGWLGWRNTRDEQLLKALADACAFDRGEHARHSTCANAKAQPTKGSKETNGQSG 354
                                                      ||.||..||
Zfish   277 ------------------------------------------HSGCALFKA-------------- 285

  Fly   355 LSGKSSPSL-----DDSSHEELTLDEIKKILIVDARSYTSAVTNRARGGGCECIEYYPCAEIEFM 414
                |.||:     |..||.:..:..:       ||:|..:|...      :..|..|
Zfish   286 ----SFPSMTQEDGDFQSHLDTMITAV-------ARNYLYSVKTE------DLSESLP------- 326

  Fly   415 NLGNIHAIRKSFHAVRQ--LCASSPD----DPNWYGQLEKTMWMQHLSGLLGATMTVVHTIEKNG 473
               .:..|::|::..:|  |..::.|    |..|:..||.:.|:..:...|...:.||..:||:.
Zfish   327 ---TLQDIQQSYNKFKQYFLIDNTTDFWLSDVKWFSSLESSGWLDIIRQCLQKAVEVVECLEKDN 388

  Fly   474 RPVLVHCSDGWDRTPQIVATAQLCLDPYYRTVEGFRVLVEREWLNFGHKFADRSGNGPNSDEVNE 538
            ..||:...:|.|....|.:.||:.|||||||:.||:.||::||:...|.|.||..:....|   :
Zfish   389 TNVLITEEEGTDLCCVISSLAQIMLDPYYRTLMGFQSLVQKEWVAGCHAFLDRCNHLHQKD---K 450

  Fly   539 RC--PVFLQWLDLVHQIHRQYPCSFEFSISYLIKLAQHSLSCLFGTFLCNSLRERIENSVF---- 597
            .|  ||||.:|:.|.|:.:|:..:|:||.:||..|:......:|.|||.||...|  .||.
Zfish   451 ECHSPVFLLFLECVWQLVQQHSPAFQFSETYLTVLSDSVHVPIFSTFLFNSAHHR--ESVMKAES 513

  Fly   598 ----DRTFS---VWPF------LAETMYRNPLY----KHETEKVLWPAHSVRFLYFWSDVYLGSL 645
                .|..|   ||.:      .|:..:.||||    ||  |:.:...|..:   ....:.|.|.
Zfish   514 PIAQSRPLSCPTVWDWSVQFDSKAQNFFFNPLYSEKVKH--ERTVRRPHKHK---HQRQLSLPSS 573

  Fly   646 GNKNGTDLPLLSNERQSGHNGLMAKTRSSEDLTTNELGQSTISRRSSDPNLTVESIVTDCFNANS 710
            ..|..|......:|..|....|..|               .|||....|:..|
Zfish   574 AFKTPTKKGFFKDETDSLKKMLRVK---------------RISRWMGSPDSPV------------ 611

  Fly   711 NSMFDIRSEANNSVSENVQESVKDSKEVELDVTDATEVGP-----CGRSNNPIPDFH--NDQSTA 768
                    .|:....|:.|:...|...:.|...|    ||     ..|....||:.|  ...|.|
Zfish   612 --------VASREFYESWQQRPLDYHGLLLPSLD----GPSVRIWMQRYLRWIPEVHIMGGGSVA 664

  Fly   769 SKRDILEVESQT--------QRRSSL------------------ESSQLIPGSVFIFGSSENDKN 807
            ....::|:.||.        ||..||                  .|.:|.....|.:..:.:.|.
Zfish   665 IMTKLMELLSQVEDLKRVLEQRDPSLATQPDHPPPLHHRLPSFGSSGRLSSSFPFTYSRNRSFKP 729

  Fly   808 AVPSESEESLATSQKLNSE 826
            .:|:...:||..:..|.::
Zfish   730 IIPTGLMQSLMVADNLANQ 748

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3632	NP_001096996.1	PH-like	35..147	CDD:302622	35/157 (22%)
		Myotub-related	221..590	CDD:284109	97/381 (25%)
		FYVE_MTMR4	1162..1221	CDD:277272
mtmr12	XP_009299937.1	PH-like	21..215	CDD:302622	47/240 (20%)
		PTPc	221..501	CDD:304379	95/378 (25%)
		3-PAP	566..692	CDD:289355	34/164 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590729
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840