DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3632 and MTMR10

DIOPT Version :9

Sequence 1:	NP_001096996.1	Gene:	CG3632 / 32589	FlyBaseID:	FBgn0030735	Length:	1250	Species:	Drosophila melanogaster
Sequence 2:	NP_060232.2	Gene:	MTMR10 / 54893	HGNCID:	25999	Length:	777	Species:	Homo sapiens

Alignment Length:	894	Identity:	201/894 - (22%)
Similarity:	320/894 - (35%)	Gaps:	270/894 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 GILALSNYRI-FLSKQSTGYETY-----------VPLGLIES-VQVRD----------------- 95
            |.|..||::| |::......:.:           |||..||. |.|.|
Human    66 GKLICSNFKISFITDDPMPLQKFHYRNLLLGEHDVPLTCIEQIVTVNDHKRKQKVLGPNQKLKFN 130

  Fly    96 LFQLIVNCKDASTVRCSFPSAEQCSDWQRRIHLMI---GVPESLETLFAFPF----YSWTCDVLG 153
            ..:||:.|||...||..|.  |...:..:::.|.|   ..|..|:.||||.:    |..:.:.:.
Human   131 PTELIIYCKDFRIVRFRFD--ESGPESAKKVCLAIAHYSQPTDLQLLFAFEYVGKKYHNSANKIN 193

  Fly   154 ---SGNGSGIVSAQANGNGLIAKDRCLTLHNGLAKPTANVTASNPLPDPASETISAAMSNRLQRS 215
               ||:|.|     ..|.|           ||....::..|       |..||.
Human   194 GIPSGDGGG-----GGGGG-----------NGAGGGSSQKT-------PLFETY----------- 224

  Fly   216 VRYESDFKNEVARLGFDLKGSWRISTANADFKLCPSYPPKLLVPCCITDEMLHNVANFRGSRRLP 280
                ||:..|:.|.|   ...||:.:.|..:.:....|..::||..:.|:.|...::....||:|
Human   225 ----SDWDREIKRTG---ASGWRVCSINEGYMISTCLPEYIVVPSSLADQDLKIFSHSFVGRRMP 282

  Fly   281 AVVWRHQKSGAILARCSQPEVGWLGWRNTRDEQLLKALADACAFDRGEHARHSTCANAKAQPTKG 345
            ...|.|....|::......:|  |..|.. |:::..|:.
Human   283 LWCWSHSNGSALVRMALIKDV--LQQRKI-DQRICNAIT-------------------------- 318

  Fly   346 SKETNGQSGLSGKSSPSLDDSSHEELTLDEIKKILIVDARSYTSAVTNRARGGGCECIEYYPCAE 410
                        ||.|...|....:|.
Human   319 ------------KSHPQRSDVYKSDLD-------------------------------------- 333

  Fly   411 IEFMNLGNIHAIRKSFHAVRQLCASSP---DDPNWYGQLEKTMWMQHLSGLLGATMTVVHTIEKN 472
               ..|.||..::.:|..::|||.:.|   .:..|...||.|.|::::...|..:..:|:.:|..
Human   334 ---KTLPNIQEVQAAFVKLKQLCVNEPFEETEEKWLSSLENTRWLEYVRAFLKHSAELVYMLESK 395

  Fly   473 GRPVLVHCSDGWDRTPQIVATAQLCLDPYYRTVEGFRVLVEREWLNFGHKFADRSGNGPNSDEVN 537
            ...|::...:|.|.:..:.:..|:.||||:||:.||:.|:::||:..|::|.||..:...|:
Human   396 HLSVVLQEEEGRDLSCCVASLVQVMLDPYFRTITGFQSLIQKEWVMAGYQFLDRCNHLKRSE--- 457

  Fly   538 ERCPVFLQWLDLVHQIHRQYPCSFEFSISYLIKLAQHSLSCLFGTFLCNSLRERIENSV------ 596
            :..|:||.:||...|:..|||.:||||.:||..|...:...||||||.||..:|::.|.
Human   458 KESPLFLLFLDATWQLLEQYPAAFEFSETYLAVLYDSTRISLFGTFLFNSPHQRVKQSTEFAISK 522

  Fly   597 -----------FDRTFSVW----PFLAE--TMYRNPLYKHETEKVLWPAHSVRFLYFWSDVYLGS 644
                       |.   |||    .|.|:  |::.||.|..::...:... ||:........|..:
Human   523 NIQLGDEKGLKFP---SVWDWSLQFTAKDRTLFHNPFYIGKSTPCIQNG-SVKSFKRTKKSYSST 583

  Fly   645 LGN-----KNG--TDLPLLSNERQSGHNGLMAKTRSSEDLTTNELGQSTISRRSSDPNLTVESIV 702
            |..     |||  :|..||..     .|.|:.|.:.       :..|.|.|:.|.     .|...
Human   584 LRGMPSALKNGIISDQELLPR-----RNSLILKPKP-------DPAQQTDSQNSD-----TEQYF 631

  Fly   703 TDCFNANSNSMFDIRSEANNSVSENVQESVKDSK--------EVELDVTDATEVGPCGRSNNPIP 759
            .:.|:..:|....|....:.:       .:|..|        |.::.:            ...|.
Human   632 REWFSKPANLHGVILPRVSGT-------HIKLWKLCYFRWVPEAQISL------------GGSIT 677

  Fly   760 DFHNDQSTASKRDILEVESQTQRRSSLESSQLIPGSVFIFGSSENDKNAVPSESEESLATSQKLN 824
            .||.....|.:.|:|....:.||...||:..   |.:   |.|....||......::
Human   678 AFHKLSLLADEVDVLSRMLRQQRSGPLEACY---GEL---GQSRMYFNASGPHHTDT-------- 728

  Fly   825 SESGRPFFIFGSSENDQSPVP---LKSEDTSDISRALWHGAIETSTDTL 870
              ||.|.|:  ||....|||.   .:|...:.:|:.|....|..||:||
Human   729 --SGTPEFL--SSSFPFSPVGNLCRRSILGTPLSKFLSGAKIWLSTETL 773

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3632	NP_001096996.1	PH-like	35..147	CDD:302622	32/122 (26%)
		Myotub-related	221..590	CDD:284109	88/371 (24%)
		FYVE_MTMR4	1162..1221	CDD:277272
MTMR10	NP_060232.2	PH-GRAM_MTMR10	21..195	CDD:270154	32/130 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	196..217		8/36 (22%)
		Myotub-related	226..507	CDD:284109	86/368 (23%)
		3-PAP	578..705	CDD:289355	30/162 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155565
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840