DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3632 and Sbf

DIOPT Version :9

Sequence 1:	NP_001096996.1	Gene:	CG3632 / 32589	FlyBaseID:	FBgn0030735	Length:	1250	Species:	Drosophila melanogaster
Sequence 2:	NP_477401.2	Gene:	Sbf / 41427	FlyBaseID:	FBgn0025802	Length:	1993	Species:	Drosophila melanogaster

Alignment Length:	952	Identity:	238/952 - (25%)
Similarity:	365/952 - (38%)	Gaps:	240/952 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 MVP--IHTMSDGSPPPSICFIRAAESYPKSQMEKEDSQLFVPFQELAGESIKYL----GRTD--- 59
            |||  :|...:...|..:    .|:.:|..|..|..:...:|.::|..:.::..    ||.|
  Fly   894 MVPGVVHMHIESLEPVYL----EAKRHPHVQKPKIQTPCLLPGEDLVTDHLRCFLMPDGREDETQ 954

  Fly    60 -----DGILALSNYRIFL--------------------------SKQSTGYETYVPLGLIESVQV 93
                 :|.|.|:|||:..                          .|.|..|..::...|.|.:|:
  Fly   955 CLIPAEGALFLTNYRVIFKGSPCDPLFCEQVIVRTFPIASLLKEKKISVLYLAHLDQTLTEGLQL 1019

  Fly    94 R-DLFQLIVNCKDASTVRCSFPSAEQCSDWQRRIHLMIGVPESLETLFAFPFYSWTCDVLGSGNG 157
            | ..||||....|...      :.||...: |:|......|......|||..|....
  Fly  1020 RSSSFQLIKVAFDPEV------TPEQIESF-RKILSKARHPFDEFEYFAFQSYGTML-------- 1069

  Fly   158 SGIVSAQANGNGLIAKDRCLTLHNGLAKPT----------------------------ANVTASN 194
            .|:..       |..|::..|| .|.||.|                            |:...:.
  Fly  1070 QGVAP-------LKTKEKYSTL-KGFAKKTLLRGAKKAGFKQKQQTKRKLVSDYDYGSADAQETQ 1126

  Fly   195 PLPDPAS-----ETISAAMSNRL-------QRSVRYESDFKNEVARLGFDLKG--SWRISTANAD 245
            .:.|...     ||.:.||...|       .|...|..|:|    |||||.:.  .:|||.||..
  Fly  1127 SIDDELEDGDEFETQNNAMPRLLTTKDVERMRERSYVQDWK----RLGFDAESQRGFRISNANTS 1187

  Fly   246 FKLCPSYPPKLLVPC-CITDEMLHNVANFRGSRRLPAVVWRHQKSGAILARCSQPE----VGWLG 305
            :..|.|||..::.|. |....::|....|:| :|:|...||| .:||:|.|..||.    :|.|
  Fly  1188 YATCRSYPAIIVAPVQCSDAAIMHLGRCFKG-QRIPLPTWRH-ANGALLIRGGQPNSKSVIGML- 1249

  Fly   306 WRNT----------------RDEQLLK-----------ALADACAFDRGEHARHSTCANAKAQP- 342
             :||                :|:..|.           ||......:....:.....::...||
  Fly  1250 -KNTTGSTTNAHHDVTHYPEQDKYFLALINTMPKLTPLALNQYSGMNLSMSSLMGHSSSDDRQPL 1313

  Fly   343 --------------TKGSKETNGQSGLSGKSSPSLDDSSHEELTLDEIKKILIVDARSYTSAVTN 393
                          :.|:|.:.|..|.:.|.:|. :..:|      ..:|:.:......:.|.:|
  Fly  1314 TPELSRKHKNNLDISDGNKSSQGGKGGTMKGNPK-NSLAH------PFRKMRLYALGEKSQAKSN 1371

  Fly   394 RARGGGCECIEYYPCAEIEFMNLGNIHAIRKSFHAVRQLCASS-----PDDPNWYGQLEKTMWMQ 453
            ..       :::  ||:...::..:|...|.:|..:.:.|..|     .|..::...:|::.|:|
  Fly  1372 MN-------VDF--CADFIPVDYPDIRQSRPAFKKLIRACMPSHNTNEADGQSFAKMVEQSDWLQ 1427

  Fly   454 HLSGLLGATMTVVHTIEKNGRPVLVHCSDGWDRTPQIVATAQLCLDPYYRTVEGFRVLVEREWLN 518
            .:|.|:..:..||..|:.....|::...||.|.|.|:.:.||||||||||:::|||||||:|||.
  Fly  1428 QISSLMQLSGAVVDLIDLQESSVMLSLEDGSDVTAQLSSIAQLCLDPYYRSLDGFRVLVEKEWLA 1492

  Fly   519 FGHKFADRSGNGPNSDEVN-ERCPVFLQWLDLVHQIHRQYPCSFEFSISYLIKLAQHSLSCLFGT 582
            |||:||.||...|:....| ...|.|||:||:|||:.||:|.:|||:..||..||.||:||.|.|
  Fly  1493 FGHRFAHRSNLKPSHANTNIAFAPTFLQFLDVVHQLQRQFPMAFEFNDFYLRFLAYHSVSCRFRT 1557

  Fly   583 FLCNSLRERIENSVF---DRTFSV---WPFLAETMYRN------PLYKHETEKVLWPAHSVRFLY 635
            ||.:...||.::.:.   |:..|:   ..|.|..|..|      .:|..:......||...|..:
  Fly  1558 FLFDCELERSDSGIAAMEDKRGSLNAKHMFGAGGMATNGSDDECSVYPLDIRSQRAPAPLNRIGH 1622

  Fly   636 FWSDVYLGSLGNKNGTDLPLLSNERQSGHNGLMAKTRSSE---DL----TTNELGQSTISRRSSD 693
            ...| |:....||.    |:..|...||...:..:.:::.   ||    |..||.|..    ..|
  Fly  1623 SIFD-YIERQHNKT----PIFYNFLYSGDKSVTLRPQNNVAALDLWCYYTNEELAQGA----PYD 1678

  Fly   694 PNLTVESIVTDCFNANSNSM-----FDIRSEANNSVSENVQESVKDSKEVE--------LDVTDA 745
            ..:|......|........|     :|...:.|.|....:...||.: |.|        |.|.::
  Fly  1679 LEVTTVDDEIDLSETKGKRMVITAGYDNMEKCNPSAYVCLLSEVKQA-ETERGHLPQKWLQVWNS 1742

  Fly   746 TEVGPCGRSNNPIPDFHNDQSTASKRDILEVESQTQRRSSLE 787
            .||          |.........|..:|. |::...:||:||
  Fly  1743 LEV----------PQLEPVARNTSLGNIF-VQTHQHKRSTLE 1773

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3632	NP_001096996.1	PH-like	35..147	CDD:302622	33/150 (22%)
		Myotub-related	221..590	CDD:284109	130/423 (31%)
		FYVE_MTMR4	1162..1221	CDD:277272
Sbf	NP_477401.2	uDENN	1..91	CDD:214824
		DENN	142..325	CDD:280329
		dDENN	384..452	CDD:129037
		SBF2	585..807	CDD:289132
		PH-GRAM_MTMR5_MTMR13	933..1047	CDD:275396	25/120 (21%)
		Myotub-related	1161..1565	CDD:284109	131/427 (31%)
		C1	1791..1838	CDD:237996
		PH_Sbf1_hMTMR5	1888..1993	CDD:269941
		PH	1891..1992	CDD:278594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462307
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10807
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940