DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3632 and mtmr4

DIOPT Version :9

Sequence 1:	NP_001096996.1	Gene:	CG3632 / 32589	FlyBaseID:	FBgn0030735	Length:	1250	Species:	Drosophila melanogaster
Sequence 2:	XP_002667032.4	Gene:	mtmr4 / 393584	ZFINID:	ZDB-GENE-040426-1208	Length:	1107	Species:	Danio rerio

Alignment Length:	1265	Identity:	431/1265 - (34%)
Similarity:	623/1265 - (49%)	Gaps:	259/1265 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 PPSICFIRAAESYPKSQMEKEDSQLFVPFQELAGESIKYLGRTDDGILALSNYRIFLS-KQSTGY 79
            |||:.:|:|.:.:|:.::.|||..|.|||..|.||.:::|||.||.::|:||||:.:. |.|.
Zfish    18 PPSLEYIQARDLFPQKELLKEDDTLQVPFPVLQGEWVEFLGRADDAVIAISNYRLHIKFKDSI-- 80

  Fly    80 ETYVPLGLIESVQVRDLFQLIVNCKDASTVRCSFPSAEQCSDWQRRIHLMIGVPESLETLFAFPF 144
             ..|||.|||||:.||:|||.:.|||:..|||.|.:.:||.:|.:|:...|..|..||.|||..:
Zfish    81 -INVPLRLIESVESRDMFQLHIICKDSKVVRCHFSTFKQCEEWLKRLQRAITHPARLEELFALAY 144

  Fly   145 YSWTCDVLGSGNGSGIVSAQANGNGLIAKDRCLTLHNGLAKPTANVTASNPLPDPASETISAAMS 209
            ::| |  ||:....              :|:    |..|.:|..:|                  .
Zfish   145 HAW-C--LGANTDD--------------EDQ----HLHLCRPGDHV------------------R 170

  Fly   210 NRLQRSVRYESDFKNEVARLGFDLKGSWRISTANADFKLCPSYPPKLLVPCCITDEMLHNVANFR 274
            :||:          .||.|:|||::.:||:|..|.::|||.|||.|||||..|||:.|.:||:||
Zfish   171 HRLE----------VEVKRMGFDMQNAWRVSDINTNYKLCSSYPQKLLVPVWITDKELESVASFR 225

  Fly   275 GSRRLPAVVWRHQKSGAILARCSQPEVGWLGWRNTRDEQLLKALADACAFDRGEHARHSTCANAK 339
            ..:|:|.||:|||::||::|||||||:.|.|||||.||.|:.::|.||..|.|..|..|
Zfish   226 SWKRIPVVVYRHQRNGAVIARCSQPEISWWGWRNTEDEYLVTSIAKACQLDGGSRAGRS------ 284

  Fly   340 AQPTKG---SKETNGQSGLSGKSSPSLDDSSHEELTLDEIKKILIVDARSYTSAVTNRARGGGCE 401
                :|   ..:::..|.|:|..:|   |||      ...:|:||:||||||:||.|||:|||||
Zfish   285 ----RGDGPDSDSDFDSSLTGCPAP---DSS------AAAQKLLILDARSYTAAVANRAKGGGCE 336

  Fly   402 CIEYYPCAEIEFMNLGNIHAIRKSFHAVRQLCASSPDDPNWYGQLEKTMWMQHLSGLLGATMTVV 466
            |.||||..|:.||.:.|||:||.||.::|.:|:..||..||...||.|.|:||||.:|.|...|.
Zfish   337 CEEYYPNCEVMFMGMANIHSIRNSFQSLRAVCSQIPDPGNWLSALESTRWLQHLSVMLKAASLVC 401

  Fly   467 HTIEKNGRPVLVHCSDGWDRTPQIVATAQLCLDPYYRTVEGFRVLVEREWLNFGHKFADRSGNGP 531
            ..:|::||||||||||||||||||||.|::.|||:|||:|||:||||.|||:||||||||.|:..
Zfish   402 SALERDGRPVLVHCSDGWDRTPQIVALAKILLDPFYRTIEGFQVLVETEWLDFGHKFADRCGHQE 466

  Fly   532 NSDEVNERCPVFLQWLDLVHQIHRQYPCSFEFSISYLIKLAQHSLSCLFGTFLCNSLRERIENSV 596
            |.|:|:|:|||||||||.|||:.:|:||.|||:.::|:||.||:.|||:||||||:.:||...:|
Zfish   467 NGDDVSEQCPVFLQWLDCVHQLLKQFPCLFEFNEAFLVKLVQHTYSCLYGTFLCNNGKERETRNV 531

  Fly   597 FDRTFSVWPFL--AETMYRNPLYKHETEKVLWPAHSVRFLYFWSDVYLGSLGNKNGTD------- 652
            :.||.|:|..|  ....::|.||....:.||.|....|.|..|:.|||.|.......:
Zfish   532 YKRTCSIWSLLRTGNKNFQNFLYIPCHDMVLQPVCHTRALQLWTAVYLPSSSPCTAAEDAVEVYL 596

  Fly   653 LPLLSNERQSGHNGL--MAKTRSSEDLTTNELGQSTISRRSSDPNLTVES-------------IV 702
            .|...:..:.....|  :.||||.::|.:......|::|.||||||....             |:
Zfish   597 SPGAGDREEFSSRSLDRLPKTRSMDNLLSACENGVTLTRTSSDPNLNKHCPEGRPSLEPNPPLIL 661

  Fly   703 TDCFNANSNSMFDIRSEANNSVSENVQESVKDSKEVELDVTDATEVGPCGRSNNPIPDFHNDQST 767
            .....|       :|.|..|..| ...|.::|.:.||          || .:..|:|.....
Zfish   662 APDAGA-------LREELENHQS-LPSEQLEDDQGVE----------PC-LTTQPLPSIPRP--- 704

  Fly   768 ASKRDILEVES------QTQRRSSLESSQLIPGSVFIFGSSENDKNAVPSESEESLATSQKLNSE 826
                  |.:|.      ..|....:..|.|.|..|.:             .:.|..:|:...|.
Zfish   705 ------LAIEQAPPPLISNQSPPQITHSPLPPSDVHV-------------RTAEITSTASLCNG- 749

  Fly   827 SGRPFFIFGSSENDQSPVPLKSEDTSDISRALWHGAIETSTDTLIPAEPVQKPNSDNS------- 884
                   |...||.:       |.:||        ::||.|:..:..| |:||:...:
Zfish   750 -------FAHVENTR-------ESSSD--------SVETLTEQSVCVE-VKKPDEVRNGALVLLR 791

  Fly   885 SRDHITSPTMELVSGDRKLESTSTV-QASKISQSYNNLPKVHIRPNAVI---CPQRVDAFPHH-- 943
            .|.|    .:|.....|:|.|||.: ..|.:...::::       ..::   |...:....:|
Zfish   792 ERPH----AVEYAKTARRLISTSPLPDLSLLGSQWDSV-------QGMVQSACGGAIQHGSYHGR 845

  Fly   944 ------LDLQVPRETTGNPDRCKPEKLAKDANANANANGSLLASDGYNGEESLFISPDLQRFVGQ 1002
                  |..|......|.| .|..:.|....:...:...|.:.|.||....|..:.|.|::.:
Zfish   846 RLANKLLRAQAGSSVGGGP-CCHRDPLRAPGSPIQSGWFSAVKSSGYAALCSSSLGPSLRQLL-- 907

  Fly  1003 SPFDAPSTGGRIRRNTFGSSYSRDMKFTAENGSAHQFPSSGIISLPPTPFQERAQFTISCPDGLA 1067
            .....||.|        .|:|..|                                     |||.
Zfish   908 PSHSCPSAG--------SSAYLDD-------------------------------------DGLP 927

  Fly  1068 HGLSEQNIRLHQIVQEHKLREEMLLREIHGMRLALLEKGCPSCNSIVSTNMEHENG------SDI 1126
            ..|.....||.||...:|...|:|.|::..::|.|..|  ..|......::::|:.      ||.
Zfish   928 VALDAVQQRLRQIEASYKQEVEVLRRQVRQLQLKLESK--QFCTPPSEPDVDYEDDITCLRESDG 990

  Fly  1127 VENASTCSWEAVEERSGPASYAPSSIQEKKASSVLWVPDHAVSRCSSCQTEFWLGRRKHHCRSCG 1191
            .|::.:.|..: |:|....|:  ..::.|......|||||..|.|.:|..|||:.:|:||||:||
Zfish   991 SEDSDSLSSRS-EDRFSEGSW--DRVERKDTEVTRWVPDHMASHCFNCDCEFWIAKRRHHCRNCG 1052

  Fly  1192 EIFCADCSEFWAPLPNEKLFNPVRLCGSCY 1221
            .:||.||.....|:|:::|::||.:|.:||
Zfish  1053 NVFCKDCCHLKLPIPDQQLYDPVLVCNTCY 1082

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3632	NP_001096996.1	PH-like	35..147	CDD:302622	53/112 (47%)
		Myotub-related	221..590	CDD:284109	203/371 (55%)
		FYVE_MTMR4	1162..1221	CDD:277272	28/58 (48%)
mtmr4	XP_002667032.4	PH-like	35..148	CDD:302622	54/116 (47%)
		Myotub-related	172..525	CDD:284109	205/381 (54%)
		FYVE_MTMR4	1023..1082	CDD:277272	28/58 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D191120at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010