DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3632 and CG3530

DIOPT Version :9

Sequence 1:	NP_001096996.1	Gene:	CG3632 / 32589	FlyBaseID:	FBgn0030735	Length:	1250	Species:	Drosophila melanogaster
Sequence 2:	NP_726322.1	Gene:	CG3530 / 37707	FlyBaseID:	FBgn0028497	Length:	761	Species:	Drosophila melanogaster

Alignment Length:	925	Identity:	210/925 - (22%)
Similarity:	358/925 - (38%)	Gaps:	279/925 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 ESIKYLGRTDD-----GILALSNYRIFLSKQSTGYETYVPLGLIESVQVRDL----FQLIVNCKD 105
            |:::.:.|.:.     |.|.|:...:...:..:..||::....:.|::...|    ..|::.||.
  Fly    82 ENVRMIDRYNTKNPTVGTLYLTATHLIFVEPDSNKETWILHMHVASIEKLPLSTTGSPLLIRCKT 146

  Fly   106 ASTVRCSFPSAEQCSDWQRRIHLMIGVPESLETLFAFPFYSWTCDVLGSGNGSGIVSAQANGNGL 170
            ..:|....|...:|.|....: |.:..|.|:..|:.|.:                   |.|
  Fly   147 FLSVTFVIPKDSECHDVYTSL-LKLFQPVSINKLYCFNY-------------------QPN---- 187

  Fly   171 IAKDRCLTLHNGLAKPTANVTASNPLPDPASETISAAMSNRLQRSVRYESDFK-----NEVARLG 230
              ||                    ..|..|....           .:.|::||     ||
  Fly   188 --KD--------------------DFPKNAGWDY-----------FKLEAEFKHMLVPNE----- 214

  Fly   231 FDLKGSWRISTANADFKLCPSYPPKLLVPCCITDEMLHNVANFRGSRRLPAVVWRHQKSGAILAR 295
                 :|.:.:.|..::||.:||.::.||...|..||.:.:.||...|||.:.:.|....:| .|
  Fly   215 -----AWTLCSMNEKYELCDTYPRQIYVPKEATTLMLISSSRFRSKGRLPVLTYLHNNKASI-CR 273

  Fly   296 CSQPEVGWLGWRNTRDEQLLKALADACAFDRGEHARHSTCANAKAQPTKGSKETNGQSGLSGKSS 360
            ||||..|:.. |...|||:|:|:                            ::||..:..
  Fly   274 CSQPLSGFSA-RCLEDEQMLEAI----------------------------RKTNSNTDY----- 304

  Fly   361 PSLDDSSHEELTLDEIKKILIVDARSYTSAVTNRARGGGCECIEYYPCAEIEFMNLGNIHAIRKS 425
                              :.:||.|...:|:.|||.|.|.|...:|...:..|:.:.|||..|.|
  Fly   305 ------------------MYVVDTRPRINAMANRAAGKGYENEAFYENIKFHFLGIENIHVQRAS 351

  Fly   426 FHAVRQLC-ASSPDDPNWYGQLEKTMWMQHLSGLLGATMTVVHTIEKNGRPVLVHCSDGWDRTPQ 489
            ...|.:.| ..||....:...||.:.|::|:..:|..:..:.:.::| |..|:||||||||||.|
  Fly   352 LQKVLEACEQKSPTMSAFINALESSGWLKHIRSILDTSSFIANAVDK-GVSVVVHCSDGWDRTAQ 415

  Fly   490 IVATAQLCLDPYYRTVEGFRVLVEREWLNFGHKFADRSGNGPNSDEVNERCPVFLQWLDLVHQIH 554
            :.:.|||.|:|||||::||:.|:|::||.|||||::|.|:  ...:..|..|:|.|:||...|:.
  Fly   416 VCSLAQLMLNPYYRTIKGFQALIEKDWLAFGHKFSERCGH--IQTDAREVSPIFTQFLDCTWQLM 478

  Fly   555 RQYPCSFEFSISYLIKLAQHSLSCLFGTFLCNSLRERIENSVFDRTFSVWPFLAETM--YRNPLY 617
            .|...:|||:..:|:.|..|..||.||||:.|..::|::..:.:||||:|.::|..:  |.||||
  Fly   479 SQRSEAFEFNERFLLILHDHVHSCQFGTFVGNCEKDRLDLKLAERTFSLWGYMANHLNEYINPLY 543

  Fly   618 KHETEKVLWPAHSVRFLYFWSDVYLGSLGNKNGTDLPLLSNERQSGHNGLMAKTRSSEDLTTNEL 682
            |...::.:....:.:.:.||..:|                :..:||.:
  Fly   544 KPNVDEAIKANLAPQCIKFWRGMY----------------SRFESGIH----------------- 575

  Fly   683 GQSTISRRSSDPNLTVESIVTDCFNANSNSMFDIRSEANNSVSENVQESVKDSKEVELDVTDATE 747
                       |...:..::.|            ..|..||:.::||...|
  Fly   576 -----------PREPLGDVLLD------------SKEHCNSLEDHVQHLTK-------------- 603

  Fly   748 VGPCGRSNNPIPDFHNDQSTASKRDILEVESQTQRRSSLESSQLIPGSVFIFGSSENDKNAVPSE 812
                     .|..|.|..|.::|:              |:.:...||.|        :|....:|
  Fly   604 ---------RIASFKNYISKSAKK--------------LQDATSAPGKV--------NKELSSNE 637

  Fly   813 SEESLATSQKLNSESGRPFFIFGSSENDQSPVPLKSEDTSDISRALWHGAIETSTDTLIPAEPVQ 877
            ..::.....|..||       ..::::|.   |||:.:.|..|.:|  .|.::|....:|.|
  Fly   638 INDNKYNYDKKLSE-------LSAADDDH---PLKASNMSFASLSL--SAEQSSPPQALPEE--- 687

  Fly   878 KPNSDNSSRDHITSPTMELVSGDRKLESTSTVQASKISQSYNNLPKVHI-RPNAVICPQRVDAFP 941
                       |.|..::.    :.:.:.:|...|.....::.  |.|. |...:.|.:.:|.
  Fly   688 -----------INSVAVDW----KPMRNVTTCSCSTPFDQFSK--KTHCWRCGDIFCERCIDK-- 733

  Fly   942 HHLDLQVPRETTGNP 956
               ::.:|...:|.|
  Fly   734 ---NVALPGHDSGKP 745

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3632	NP_001096996.1	PH-like	35..147	CDD:302622	21/105 (20%)
		Myotub-related	221..590	CDD:284109	119/374 (32%)
		FYVE_MTMR4	1162..1221	CDD:277272
CG3530	NP_726322.1	PH-GRAM_MTMR6-like	78..173	CDD:270030	17/91 (19%)
		Myotub-related	179..514	CDD:284109	128/456 (28%)
		FYVE_MTMR_unchar	693..753	CDD:277277	10/64 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462306
Domainoid	1	1.000	194	1.000	Domainoid score	I610
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D18864at33392
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46536
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10807
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.950