DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3632 and CG14411

DIOPT Version :9

Sequence 1:	NP_001096996.1	Gene:	CG3632 / 32589	FlyBaseID:	FBgn0030735	Length:	1250	Species:	Drosophila melanogaster
Sequence 2:	NP_001162756.1	Gene:	CG14411 / 32408	FlyBaseID:	FBgn0030582	Length:	843	Species:	Drosophila melanogaster

Alignment Length:	962	Identity:	191/962 - (19%)
Similarity:	328/962 - (34%)	Gaps:	343/962 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 PIHTM-SDGSPPPSICFIRAAESYPKSQMEKEDS----------QLFVPFQELAGESI------- 52
            ||..| |.|....::..|.:|...|..:..||.:          ..|||..|...::|
  Fly    80 PIDPMDSSGGSGSTLSAISSASGTPADRHHKEATFGLLSVTNFKLAFVPLHEKRNQAITAPLIDL 144

  Fly    53 ----KYLGRTDDGILALSN----YRIF-LSKQSTGYETYVPL----GLIESVQVRDLFQ------ 98
                .||||.:   :.|:|    |.|. |.:.::..:....:    |:....::....|
  Fly   145 YQENTYLGRNE---ITLNNIDHIYTITELGRAASALQAARGMASHAGMSRRKKLEPFKQQNISGR 206

  Fly    99 ---LIVNCKDASTVRCSFPSAEQ----CSDWQRRIH---LMIGVPESLETLFAF----PFYSWTC 149
               |.:.||:...::.:|...:.    .||..:.|.   :....|...:..||:    |:||
  Fly   207 IAALHIVCKNFRLLKFAFQQQDSKMFGASDQGKLIASALVRFAYPMRHDLSFAYAHREPYYS--- 268

  Fly   150 DVLGSGNGSGIVSAQANGNGLIAKDRCLTLHNGLAKPTANVTASNPLPDPASETISAAMSNRLQR 214
             .||           |:|..:.|.
  Fly   269 -TLG-----------ASGTSMYAT----------------------------------------- 280

  Fly   215 SVRYESDFKNEVARLGFDLKGSWR-ISTANADFKLCP------SYPPKLLVP-CCITDEMLHNVA 271
                ::|:..|:.|.|   ...|: :|.|:......|      :.||..::| .|..|..|....
  Fly   281 ----KNDWARELIRCG---ATEWQVVSCASVQLLQNPLQAGKYTVPPHFVIPKSCSVDRFLDLSR 338

  Fly   272 NFRGSRRLPAVVWRHQ-KSGAILARCS--QPEVGWLGWRNTRDEQLLKALADACAFDRGEHARHS 333
            .|..||   |..|.:. .|.|.|.|.:  ||    ...::|:.|.::..|...|  |.|.
  Fly   339 AFCDSR---AAFWVYSYGSSAALVRLAELQP----AAQQDTKSENVMLELVRKC--DAGR----- 389

  Fly   334 TCANAKAQPTKGSKETNGQSGLSGKSSPSLDDSSHEELTLDEIKKILIVDARSYTSAVTNRARGG 398
                                                     ::|.:.:.|
  Fly   390 -----------------------------------------QLKLLQLTD--------------- 398

  Fly   399 GCECIEYYPCAEIEFMNLGNIHAIRKSFHAVRQLCA-SSPD-----DPNWYGQLEKTMWMQHLSG 457
                            .|.:|..:.:::..:|:||. .:|:     |..:.|.||||.|:.::|.
  Fly   399 ----------------RLPSIQDVLRAYQKLRRLCTPETPEKFMLQDDKYLGLLEKTNWLFYVSL 447

  Fly   458 LLGATMTVVHTIEKNGRPVLVHCSDGWDRTPQIVATAQLCLDPYYRTVEGFRVLVEREWLNFGHK 522
            .|........|: ::|...::..|:|.|....|.:.|||.|||::||::||:.||::||:...|.
  Fly   448 CLRYASEASATL-RSGVTCVLQESNGRDLCCVISSLAQLLLDPHFRTIDGFQSLVQKEWVALEHP 511

  Fly   523 FADRSGN-------GPNSDEV-NERCPVFLQWLDLVHQIHRQYPCSFEFSISYLIKLAQHSLSCL 579
            |..|.|:       |.|::.. :|:.||||.:||.|.|:.:|:|..|||:.:||..|.......:
  Fly   512 FQRRLGHVYPAQPAGGNAELFDSEQSPVFLLFLDCVWQLLQQFPDEFEFTQTYLTTLWDSCFMPI 576

  Fly   580 FGTFLCNSLRERIENSVFDRTFSVWPFLAETMYRNPLYKHETEKVLWPAHSVRFLYFWSDVYLGS 644
            |.||..::..:|::              |.|         :::.||.|      ::.|.:.:
  Fly   577 FDTFQFDTQAQRLK--------------AVT---------DSQLVLRP------VWDWGEQF--- 609

  Fly   645 LGNKNGTDLPLLSN---ERQSGHNGLM-AKTRSSEDLTTNELGQS------TISRRSSDPNL--T 697
                :..|....||   :||.|..|.. |.......|.....|..      |.||.:.:|.|  |
  Fly   610 ----SDKDKMFFSNPLYQRQRGDLGAQAAAVAHRRSLAVGSKGAHGAASGVTPSRNTINPQLFAT 670

  Fly   698 VESIVTDCFNANSNSMFDIRSEANNSVSENVQE----------SVKDSKEVELD------VTDAT 746
            ..|:..|.:...::.:||::          |.:          .::...:.::|      :::..
  Fly   671 ASSVPQDRYLQPAHRIFDLQ----------VWDQCYYRWLPILDIRGGGQPQVDLYHRLLLSNIA 725

  Fly   747 EVGPC-----------------GRSNNPIPDFHNDQSTASKRDILEVESQTQRRSSLESSQLIPG 794
            :|..|                 |.|.   |:.|.|:. ..|.|..|.....:||
  Fly   726 KVQRCLDYQNFDDLPDAYYEFAGESR---PNQHKDEK-PDKEDEAEFVDGVERR----------- 775

  Fly   795 SVFIFGSSENDKNAVPSESEESLATSQKLNSESGRPFFIFGSSENDQSPVPL 846
                  .....|.|.|:....|:..:.:|::.|.  ||.||:.....:|:.|
  Fly   776 ------RKPTAKAATPTSGLTSVTGNLQLSTLSS--FFPFGNPIAGDAPLQL 819

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3632	NP_001096996.1	PH-like	35..147	CDD:302622	30/161 (19%)
		Myotub-related	221..590	CDD:284109	94/393 (24%)
		FYVE_MTMR4	1162..1221	CDD:277272
CG14411	NP_001162756.1	PH-like	<114..225	CDD:302622	19/113 (17%)
		PTPc	<400..587	CDD:304379	61/187 (33%)
		3-PAP	<666..732	CDD:289355	10/75 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462309
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10807
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940