DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3632 and Mtmr2

DIOPT Version :9

Sequence 1:	NP_001096996.1	Gene:	CG3632 / 32589	FlyBaseID:	FBgn0030735	Length:	1250	Species:	Drosophila melanogaster
Sequence 2:	NP_001101593.1	Gene:	Mtmr2 / 315422	RGDID:	1311865	Length:	643	Species:	Rattus norvegicus

Alignment Length:	725	Identity:	217/725 - (29%)
Similarity:	327/725 - (45%)	Gaps:	161/725 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 IHTMSDGSPPPSICFIRAAESYPKSQMEKEDSQLFVPFQELAGESIKYLGR----------TDDG 61
            |.|.:|.. .|.:..:|.|...    .|.|:..|      |.||:||.:.:          ...|
  Rat    50 ISTSADNF-SPDLRVLREANKL----AEMEEPAL------LPGENIKDMAKDVTYICPFTGAVRG 103

  Fly    62 ILALSNYRIFLS--KQSTGYETYVPLGLIESVQV--------RDLFQLIVNCKDASTVRCSFPSA 116
            .|.::|||::..  ::...:.....||:|..|:.        .:.:.|...|||...:|    .|
  Rat   104 TLTVTNYRLYFKSMERDPPFVLDASLGVISRVEKIGGASSRGENSYGLETVCKDIRNLR----FA 164

  Fly   117 EQCSDWQRRIHLMIGVPESLETLFAFPFYSWTCDVLGSGNGSGIVSAQANGNGLIAKD-RCLTLH 180
            .:.....||     .:.|:| ..:|||.                    :||..|.|.: :.:...
  Rat   165 HKPEGRTRR-----SIFENL-MKYAFPV--------------------SNGLPLFAFEYKEVFPE 203

  Fly   181 NGLAKPTANVTASNPLPDPASETISAAMSNRLQRSVRYESDFKNEVARLGFDLKGSWRISTANAD 245
            ||.           .|.||..|.....:.|.                        ||||:..|..
  Rat   204 NGW-----------KLYDPLLEYRRQGIPNE------------------------SWRITKVNER 233

  Fly   246 FKLCPSYPPKLLVPCCITDEMLHNVANFRGSRRLPAVVWRHQKSGAILARCSQPEVGWLGWRNTR 310
            ::||.:||..|.||..|.||.|..||:||...|:|.:.|.|.:|.|.:.|||||.||..|.|:..
  Rat   234 YELCDTYPALLAVPANIPDEELKRVASFRSRGRIPVLSWIHPESQATVTRCSQPMVGVSGKRSKE 298

  Fly   311 DEQLLKALADACAFDRGEHARHSTCANAKAQPTKGSKETNGQSGLSGKSSPSLDDSSHEELTLDE 375
            ||:.|:|:.|                            :|.||
  Rat   299 DEKYLQAIMD----------------------------SNAQS---------------------- 313

  Fly   376 IKKILIVDARSYTSAVTNRARGGGCECIEYYPCAEIEFMNLGNIHAIRKSFHAVRQLCASSPDDP 440
             .||.|.|||...:||.|:|:|||.|..:.|..||:.|:::.|||.:|:|...::::...:.::.
  Rat   314 -HKIFIFDARPSVNAVANKAKGGGYESEDAYQNAELVFLDIHNIHVMRESLRKLKEIVYPNIEET 377

  Fly   441 NWYGQLEKTMWMQHLSGLLGATMTVVHTIEKNGRPVLVHCSDGWDRTPQIVATAQLCLDPYYRTV 505
            :|...||.|.|::|:..:|...:.:...:|.....|:||||||||||.|:.:.|.|.||.||||:
  Rat   378 HWLSNLESTHWLEHIKLILAGALRIADKVESGKTSVVVHCSDGWDRTAQLTSLAMLMLDGYYRTI 442

  Fly   506 EGFRVLVEREWLNFGHKFADRSGNGPNSDEVNERCPVFLQWLDLVHQIHRQYPCSFEFSISYLIK 570
            .||.||||:|||:|||:|..|.|:|..:....:|.|||||::|.|.|:.||:|.:|||:..:||.
  Rat   443 RGFEVLVEKEWLSFGHRFQLRVGHGDKNHADADRSPVFLQFIDCVWQMTRQFPTAFEFNEYFLIT 507

  Fly   571 LAQHSLSCLFGTFLCNSLRERIENSVFDRTFSVWPFLAETM--YRNPLYKHETEKVLWPAHSVRF 633
            :..|..|||||||||||.::|.:.::..:|.|:|.::...:  :.|||:...:..||:|..|:|.
  Rat   508 ILDHLYSCLFGTFLCNSEQQRGKENLPKKTVSLWSYINSQLEDFTNPLFGSYSNHVLYPVASMRH 572

  Fly   634 LYFWSDVYLGSLGNKNGTDLPLLSNERQSGHNGLMAK----TRSSEDLTTNELGQST-ISRRSSD 693
            |..|...|: ....:.....|:.|..::     |:||    .|..|:|......:|| .|.|:|.
  Rat   573 LELWVGYYI-RWNPRMKPQEPIHSRYKE-----LLAKRTELQRKVEELQREISNRSTSSSERASS 631

  Fly   694 PNLTVESIVT 703
            |...|..:.|
  Rat   632 PAQCVTPVQT 641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3632	NP_001096996.1	PH-like	35..147	CDD:302622	29/131 (22%)
		Myotub-related	221..590	CDD:284109	139/368 (38%)
		FYVE_MTMR4	1162..1221	CDD:277272
Mtmr2	NP_001101593.1	PH-like	73..187	CDD:418428	29/149 (19%)
Mtmr2	NP_001101593.1	Myotub-related	202..528	CDD:399535	146/411 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349476
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D824298at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.750