DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3632 and Mtmr12

DIOPT Version :9

Sequence 1:	NP_001096996.1	Gene:	CG3632 / 32589	FlyBaseID:	FBgn0030735	Length:	1250	Species:	Drosophila melanogaster
Sequence 2:	XP_006232108.1	Gene:	Mtmr12 / 310155	RGDID:	1307902	Length:	748	Species:	Rattus norvegicus

Alignment Length:	792	Identity:	165/792 - (20%)
Similarity:	283/792 - (35%)	Gaps:	281/792 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 SPPPS-ICFIRAAESY--PKSQMEKEDSQL-FVPFQELAGES---IKYLGRTDD------GILAL 65
            :|.|| :.::|..|.:  .|...|||:..| .:|.::|..|:   :||: :.|.      |.|..
  Rat    15 APKPSFVSYVRPEEIHTNEKEVTEKEEVTLHLLPGEQLLCEASTVLKYV-QEDSCQLGICGRLVC 78

  Fly    66 SNYRI-FLSKQST----GYETY----------VPLGLIESV------QVRDLF--------QLIV 101
            :::|| ||..:.:    |.||:          :||..::.:      :.:.||        :|::
  Rat    79 TDFRISFLGDEGSAVDNGAETHFKNKIIGVNDIPLHCVDQIYGVFDEKKKPLFGQLKKYPEKLVI 143

  Fly   102 NCKDASTVR-C-SFPSAEQCSDWQRRIHLMIGV------PESLETLFAFPFYSWTCDVLGSGNGS 158
            :|||...:. | .:...|:..      .::.|:      |:.|:.||.|.:
  Rat   144 HCKDLRVLHFCLRYTKEEEVK------RIVSGIIHHTQSPKLLKRLFLFSY-------------- 188

  Fly   159 GIVSAQANGNGLIAKDRCLTLHNGLAKPTANVTASNPLPDPASETISAAMSNRLQRSVRYESDFK 223
                             ...:|...|.| .|.|.....|                      .|:.
  Rat   189 -----------------AAAVHGTAADP-RNCTVMFDTP----------------------KDWC 213

  Fly   224 NEVARLGFDLKGSWRIST--ANADFKLCPSYPPKLLVPCCITDEMLHNVANFRGSRRLPAVVWRH 286
            .|:.|    .|||.:..|  .|..:::|...|...:||..:.::   :|..|:| |.:|...|..
  Rat   214 WELER----TKGSVKYKTVSVNEGYRVCDRLPAYFVVPTPLLED---DVKRFQG-RGIPIWCWSC 270

  Fly   287 QKSGAILARCSQPEVGWLGWRNTRDE---QLLKALADACAFDRGEHARHSTCANAKAQPTKGSKE 348
            ....|:|...:.|:        .:|:   |:.|:..|..         :.|......:..|
  Rat   271 HNGSALLKMSALPK--------EQDDSALQIQKSFLDGI---------YKTIHRPPYEMVK---- 314

  Fly   349 TNGQSGLSGKSSPSLDDSSHEELTLDEI-------KKILIVDARSYTSAVTNRARGGGCECIEYY 406
                          .:|.|...|:|.||       |::.::|:.|
  Rat   315 --------------TEDLSSNFLSLQEIQSSYCKFKQLFLIDSSS-------------------- 345

  Fly   407 PCAEIEFMNLGNIHAIRKSFHAVRQLCASSPDDPNWYGQLEKTMWMQHLSGLLGATMTVVHTIEK 471
                 ||.:                      .|..|:..||.:.|:..:...|...:.::..:|.
  Rat   346 -----EFWD----------------------TDVKWFSLLESSGWLDIIRRCLKRAIEIIECLEA 383

  Fly   472 NGRPVLVHCSDGWDRTPQIVATAQLCLDPYYRTVEGFRVLVEREWLNFGHKFADRSGNGPNSDEV 536
            ....||:...:..|....:.:..|:.:|.:.||..||:.|:::||:..||.|.||..:...||:
  Rat   384 QNMNVLLLEENASDLCCLLSSLVQVMMDAHCRTWTGFQSLIQKEWVMGGHSFLDRCNHLHQSDK- 447

  Fly   537 NERCPVFLQWLDLVHQIHRQYPCSFEFSISYLIKLAQHSLSCLFGTFLCNSLRERIEN------- 594
             |..||||.:||.|.|:..|:|.:|||:.:||..|:......:|.||..||..::..|
  Rat   448 -EEVPVFLLFLDCVWQLVHQHPPAFEFTETYLTVLSDSLYIPIFSTFFFNSPHQKDTNMGRESLD 511

  Fly   595 ---------SVFDRTFSVWPFLAETMYRNPLY--KHETEKVLWPAHSVRFLYFWSDVYLGSLGNK 648
                     :|:|.:....| .|:|:.|||||  |.:.:|                      |.:
  Rat   512 AQSKPLTLLTVWDWSVQFEP-KAQTLLRNPLYVEKPKLDK----------------------GQR 553

  Fly   649 NGT--------DLPLLSNERQSGHNGLMAKTRSSEDLTTNELGQSTISR--RSSDPNLTVESIVT 703
            .|:        .|| |:..:.|...|...:  .::.|..|.||: .||:  .|||.
  Rat   554 KGSRFKHQRQLSLP-LTQSKSSPKRGFFRE--ETDHLIKNLLGK-RISKLINSSDD--------- 605

  Fly   704 DCFNANSNSMFD 715
              ...||...:|
  Rat   606 --LQDNSREFYD 615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3632	NP_001096996.1	PH-like	35..147	CDD:302622	34/158 (22%)
		Myotub-related	221..590	CDD:284109	86/380 (23%)
		FYVE_MTMR4	1162..1221	CDD:277272
Mtmr12	XP_006232108.1	PH-like	26..192	CDD:302622	37/203 (18%)
		PTPc	211..497	CDD:304379	84/377 (22%)
		3-PAP	562..686	CDD:289355	17/69 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349467
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840