DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3632 and Mtmr7

DIOPT Version :9

Sequence 1:	NP_001096996.1	Gene:	CG3632 / 32589	FlyBaseID:	FBgn0030735	Length:	1250	Species:	Drosophila melanogaster
Sequence 2:	XP_038950456.1	Gene:	Mtmr7 / 306490	RGDID:	1306608	Length:	672	Species:	Rattus norvegicus

Alignment Length:	764	Identity:	201/764 - (26%)
Similarity:	325/764 - (42%)	Gaps:	167/764 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 ESIKYLGRTDDGILAL------SNYRIFL-SKQSTGYETYVPLGLIESVQVRDL----FQLIVNC 103
            |:::.:.|......||      :.:.||: :...|..||::....|.:::.:..    ..|::.|
  Rat    22 ENVRLVDRVSCKKAALGTLYLTATHVIFVENAPDTRKETWILHSQISTIEKQATTATGCPLLIRC 86

  Fly   104 KDASTVRCSFPSAEQCSDWQRRIHLMIGVPESLETLFAFPFYSWTCDVLGSGNGSGIVSAQANGN 168
            |:...|:...|....|.|....: :.:..|...|.|:.|.|
  Rat    87 KNFQIVQLVIPQERDCHDVYVSL-IRLARPVRYEELYCFSF------------------------ 126

  Fly   169 GLIAKDRCLTLHNGLAKPTANVTASNPLPDPASETISAAMSNRLQRSVRYES----DFKNEVARL 229
                                     ||               :|.:..|.:.    |...|..|:
  Rat   127 -------------------------NP---------------KLDKEEREQGWLLVDLSEEYKRM 151

  Fly   230 GFDLKGSWRISTANADFKLCPSYPPKLLVPCCITDEMLHNVANFRGSRRLPAVVWRHQKSGAILA 294
            |.. ...|::|..|.|:::|.|||.:|.||...|..::...:.||..||.||:.:..::|.|.:.
  Rat   152 GLP-DNYWQLSDVNRDYRVCDSYPTELYVPRSATAHIIVGSSKFRSRRRFPALSYYCKESHASIC 215

  Fly   295 RCSQPEVGWLGWRNTRDEQLLKALADACAFDRGEHARHSTCANAKAQPTKGSKETNGQSGLSGKS 359
            |.|||..|:.. |...|||:|:|:.                                      |:
  Rat   216 RSSQPLSGFSA-RCLEDEQMLQAIR--------------------------------------KA 241

  Fly   360 SPSLDDSSHEELTLDEIKKILIVDARSYTSAVTNRARGGGCECIEYYPCAEIEFMNLGNIHAIRK 424
            :|..|             .|.:||.|...:|:.|||.|.|.|..:.|...:.:|:.:.|||.:|.
  Rat   242 NPRSD-------------FIYVVDTRPKLNAMANRAAGKGYENEDNYSNIKFQFIGIENIHVMRN 293

  Fly   425 SFHAVRQLC-ASSPDDPNWYGQLEKTMWMQHLSGLLGATMTVVHTIEKNGRPVLVHCSDGWDRTP 488
            |...:.::| ..||...::...||.:.|::|:..::.|.:.:...:.:.|..||||||||||||.
  Rat   294 SLQKMLEVCELKSPSMSDFLWGLENSGWLRHIKAIMDAGIFIAKAVSEEGTSVLVHCSDGWDRTA 358

  Fly   489 QIVATAQLCLDPYYRTVEGFRVLVEREWLNFGHKFADRSGNGPNSDEVNERCPVFLQWLDLVHQI 553
            |:.:.|.|.|||||||::||.||:|::|::|||||..|.||  ...:..|..||..|:::.|.|:
  Rat   359 QVCSVASLLLDPYYRTLKGFMVLIEKDWISFGHKFNHRYGN--LDGDPKEISPVIDQFIECVWQL 421

  Fly   554 HRQYPCSFEFSISYLIKLAQHSLSCLFGTFLCNSLRERIENSVFDRTFSVWPFLAETM--YRNPL 616
            ..|:||:|||:..:||.:..|..||.||.|||||.:||.|..:.:||:|:|..|.:..  |.|||
  Rat   422 MEQFPCAFEFNERFLIHIQHHVYSCQFGNFLCNSQKERRELKIQERTYSLWSNLWKNRADYLNPL 486

  Fly   617 YK---HETEKVL-WPAHSVRFLY-FWSDVY----LGSLGNKNGTD-LPLLSNERQSGHNGLMAKT 671
            ::   .:|:..| .|.....|.| ||:.:|    .|....::.|| |..:..|.|.....|.:..
  Rat   487 FRADHSQTQGSLHLPTAPYNFTYKFWNGMYNRFEKGLQPRQSVTDYLMAVKEESQQLEEELESLE 551

  Fly   672 RSSEDLTTNELGQSTISRRSSDPNLTVESIVTDCFNAN-----SNSMFDIRSEANNSVSEN---- 727
            ...|.:....|..:.:..:.|:|:.......:|...||     |.:|....|.:.:...|:
  Rat   552 ERLEKIQKVHLNGAKVKSKQSEPSKHSGFSTSDNSTANTPQDYSGNMKSFPSRSPSQGDEDSALI 616

  Fly   728 -VQESVKDSKEVELDVTDATEVG--------PCGRSNNPIPDFHNDQST 767
             .|:::| |.:.:|.|....|.|        |.|..:.|..|...|:.:
  Rat   617 LTQDNLK-SSDPDLSVNSDQESGVEDLSCRSPSGGEHAPSEDSGKDRDS 664

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3632	NP_001096996.1	PH-like	35..147	CDD:302622	22/107 (21%)
		Myotub-related	221..590	CDD:284109	125/369 (34%)
		FYVE_MTMR4	1162..1221	CDD:277272
Mtmr7	XP_038950456.1	PH-like	21..115	CDD:418428	17/93 (18%)
Mtmr7	XP_038950456.1	PTP-MTMR7	144..445	CDD:350431	115/355 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349466
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D824298at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.850