DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3632 and Mtmr3

DIOPT Version :9

Sequence 1:	NP_001096996.1	Gene:	CG3632 / 32589	FlyBaseID:	FBgn0030735	Length:	1250	Species:	Drosophila melanogaster
Sequence 2:	XP_006251364.1	Gene:	Mtmr3 / 305482	RGDID:	1310972	Length:	1207	Species:	Rattus norvegicus

Alignment Length:	1339	Identity:	457/1339 - (34%)
Similarity:	642/1339 - (47%)	Gaps:	299/1339 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 IRAAESYPKSQMEKEDSQLFVPFQELAGESIKYLGRTDDGILALSNYRIFLS-KQSTGYETYVPL 85
            |:|.:.:|:.|:.:||..|.|||.||.|||.:|:||.:|.|:||||||:.:. |:|.   ..|||
  Rat    12 IQANQIFPRKQLIREDENLQVPFLELHGESTEYVGRAEDAIIALSNYRLHIKFKESL---VNVPL 73

  Fly    86 GLIESVQVRDLFQLIVNCKDASTVRCSFPSAEQCSDWQRRIHLMIGVPESLETLFAFPFYSWTCD 150
            .|||||:.||:|||.:.|||...:||.||:.|||.||.:|::..|..|..:|.||:|.:::|..:
  Rat    74 QLIESVECRDIFQLHLTCKDCKVIRCQFPTFEQCQDWLKRLNNAIRPPGKIEDLFSFAYHAWCME 138

  Fly   151 VLGSGNGSGIVSAQANGNGLIAKDRCLTLHNGLAKPTANVTASNPLPDPASETISAAMSNRLQRS 215
            |..|                 .|::    |..|.:|..:||
  Rat   139 VYAS-----------------EKEQ----HGDLCRPGEHVT------------------------ 158

  Fly   216 VRYESDFKNEVARLGFDLKGSWRISTANADFKLCPSYPPKLLVPCCITDEMLHNVANFRGSRRLP 280
                |.|||||.|:|||:..:||||..|..:|||.|||.:|:||..|||:.|.:||.||..:|:|
  Rat   159 ----SRFKNEVERMGFDMNNAWRISNINEKYKLCGSYPQELIVPAWITDKELESVAGFRSWKRIP 219

  Fly   281 AVVWRHQKSGAILARCSQPEVGWLGWRNTRDEQLLKALADACAFD-RGEHARHSTCANAKAQPTK 344
            ||::|||.:||::|||.||||.|.||||..||.|::::|.|||.| :....:.||..:.:..|..
  Rat   220 AVIYRHQSNGAVIARCGQPEVSWWGWRNADDEHLVQSVAKACASDSQSSVGKVSTRNSCRGFPNA 284

  Fly   345 GS-KETNGQSGLSGKSSPSLDDSSHEELTLDEIKKILIVDARSYTSAVTNRARGGGCECIEYYPC 408
            |. .:....:.||..|..       |.|.| :.:|:||:|||||.:||.|||:||||||.||||.
  Rat   285 GDLSDVEFDASLSNASGT-------ESLAL-QPQKLLILDARSYAAAVANRAKGGGCECPEYYPN 341

  Fly   409 AEIEFMNLGNIHAIRKSFHAVRQLCASSPDDPNWYGQLEKTMWMQHLSGLLGATMTVVHTIEKNG 473
            .|:.||.:.|||:||:||.::|.||...||..||...||.|.|:.|||.||.:.:.|||.::::.
  Rat   342 CEVVFMGMANIHSIRRSFQSLRLLCTQMPDPGNWLSALESTKWLHHLSVLLKSALLVVHAVDRDQ 406

  Fly   474 RPVLVHCSDGWDRTPQIVATAQLCLDPYYRTVEGFRVLVEREWLNFGHKFADRSGNGPNSDEVNE 538
            |||||||||||||||||||.|:|.|||||||||||:||||.|||:||||||||.|:|.|||::||
  Rat   407 RPVLVHCSDGWDRTPQIVALAKLLLDPYYRTVEGFQVLVEMEWLDFGHKFADRCGHGENSDDLNE 471

  Fly   539 RCPVFLQWLDLVHQIHRQYPCSFEFSISYLIKLAQHSLSCLFGTFLCNSLRERIENSVFDRTFSV 603
            ||||||||||.|||:.||:||||||:.::|:||.||:.||||||||||:.:||.|....:||.||
  Rat   472 RCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLVQHTYSCLFGTFLCNNAKERGEKQTQERTCSV 536

  Fly   604 WPFL--AETMYRNPLYKHETEKVLWPAHSVRFLYFWSDVYLGSLGNKNGTD-----LPLLSNERQ 661
            |..|  ....::|.||..::|.||:|...||.|..||.|||........||     .|.......
  Rat   537 WSLLRAGNKAFKNLLYSSQSEAVLYPVCHVRNLMLWSAVYLPCPSPSTPTDDSCAPYPAPGTSPD 601

  Fly   662 SGHNGLMAKTRSSEDLTTN-ELGQSTISRRSSDPNLTVE------SIVTDCFNANSNSMFDIRS- 718
            ......:.||||.::|||. :......|||||||:|..:      |:....|..:...:..|.|
  Rat   602 EPPLSRLPKTRSFDNLTTTCDNMVPLASRRSSDPSLNEKWQEHGRSLELSSFAGSGEEVPAIDSL 666

  Fly   719 --------EANNSVS--------ENV-QESVKDSKEVELDVTDATEVGPCGRSNNPIPDFHNDQS 766
                    .|..||:        ||: ||:.|:...||         .|..|.:..:|:...:..
  Rat   667 RRPSRLLGGAELSVAAGVAEGQMENILQEATKEESGVE---------EPTHREHTEVPEVKEEAP 722

  Fly   767 TASKRDILEVESQTQRRSSLESSQLIPGSVFIFGSSENDKNAVPSESEESLAT-SQKLNSESGRP 830
            .|.       ||:|..:          ||..::...:.|...:.|....||:: ||.:.......
  Rat   723 LAK-------ESRTAAQ----------GSGVLYQEPQLDDATLRSHLGPSLSSFSQGIPEHREVG 770

  Fly   831 FFIFGSSENDQSPVPLKSEDTSDISRALWHGAIETSTDTLIPAEPVQKPNSDNSSRDHITSPTME 895
            ..:..||    .|..|:.||:.::                    ||::|..:|.:.|.  ...:.
  Rat   771 HSVLSSS----LPASLRGEDSQEV--------------------PVEQPQVENIAEDR--ENVVP 809

  Fly   896 LVSGDRKLESTSTVQASKISQSYNNLPKVHIRPNAVICPQRVDAFPHHLDLQVPRETTG-----N 955
            .|..|.|: ...|.::|.:      ||.                       |||.||.|     :
  Rat   810 AVPVDVKI-GLGTSESSPL------LPS-----------------------QVPFETRGPHMNNS 844

  Fly   956 PDRCKPEKLAKDANANANANGSLLASDGYNGEESLFISPD------------LQR---------F 999
            ......:|:..::....:....|.:|..::|::.|.|:|:            |.|         .
  Rat   845 VHMLLEDKVKSESGPQLHHRPCLASSGRFSGKDMLPIAPEPRSAERPQWDSVLHRTSSPGNTLSL 909

  Fly  1000 VGQSPFDAPSTGGRIRRNTFGSSYSRDMKFTAENGSAHQFPSSGIISLPPTPFQERAQ-FTISCP 1063
            :.|:|...|....|.|....|:       ...||.::.|......:...|||....|. .|....
  Rat   910 MMQAPCALPLDKCRQRIVCNGA-------LETENKASEQPAGFDTLQKYPTPNGHCANGETGRSK 967

  Fly  1064 DGLAHGLS----------EQNI----------------------------------------RLH 1078
            |.|:|.||          .:|:                                        ||.
  Rat   968 DSLSHQLSATSYSSAHSCSRNLHHKWLNSHSGRPSTTNSPEQPSRSHLDDDGMPVYTDTIQQRLR 1032

  Fly  1079 QIVQEHKLREEMLLREIHGMRLALLEKGCPSCNSIVSTNMEHENG-------------SDIVENA 1130
            ||...|:...|.|.:::..::..|        .|...|:....||             |::.:|.
  Rat  1033 QIESGHQQEVETLKKQVQELKSRL--------ESQYLTSSLRFNGDFGDEVTSIPDSESNLDQNC 1089

  Fly  1131 -STCSWEAVEERSGPASYAPSSIQEKKASSVLWVPDHAVSRCSSCQTEFWLGRRKHHCR------ 1188
             |.||.|...|.|.      ..:.::......|:|||..:.|.:|.:.|||..||||||
  Rat  1090 LSRCSTEIFSEASW------EQVDKQDTEMTRWLPDHLAAHCYACDSAFWLASRKHHCRDTDRVD 1148

  Fly  1189 ---SCGEIFCADCSEFWAPLPNEKLFNPVRLCGSCYTSV 1224
               :||.:||:.|.....|:|:::||.|.|:|.|||:|:
  Rat  1149 QTWNCGNVFCSSCCNQKVPVPSQQLFEPSRVCKSCYSSL 1187

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3632	NP_001096996.1	PH-like	35..147	CDD:302622	56/112 (50%)
		Myotub-related	221..590	CDD:284109	212/370 (57%)
		FYVE_MTMR4	1162..1221	CDD:277272	28/67 (42%)
Mtmr3	XP_006251364.1	PH-GRAM_MTMR3	23..116	CDD:270149	50/95 (53%)
		PTP-MTMR3	169..485	CDD:350434	181/323 (56%)
		FYVE_MTMR3	1115..1184	CDD:277271	28/68 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349473
Domainoid	1	1.000	453	1.000	Domainoid score	I482
eggNOG	1	0.900	-	-		E1_KOG4471
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	675	1.000	Inparanoid score	I695
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D191120at33208
OrthoFinder	1	1.000	-	-		FOG0004824
OrthoInspector	1	1.000	-	-		otm44560
orthoMCL	1	0.900	-	-		OOG6_105196
Panther	1	1.100	-	-	LDO	PTHR10807
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2890
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.760