Protein Alignment CG3632 and Mtmr12

DIOPT Version :10

• Sequence 1: NP_001096996.1
• Gene: CG3632 / 32589
• FlyBaseID: FBgn0030735
• Length: 1250
• Species: Drosophila melanogaster
• Sequence 2: NP_766546.1
• Gene: Mtmr12 / 268783
• MGIID: 2443034
• Length: 747
• Species: Mus musculus
• Alignment Length: 758
• Identity: 155/758 - (20%)
• Similarity: 271/758 - (35%)
• Gaps: 247/758 - (32%)

  Fly    14 SPPPS-ICFIRAAESY--PKSQMEKEDSQLFVPFQELAGES---IKYLGRTDD------GILALS 66
            :|.|| :.::|..|.:  .|...|||.:...:|.::|..|:   :||: :.|.      |.|..:
Mouse    15 APKPSFVSYVRPEEIHTDEKEVTEKEVTLHLLPGEQLLCEASTVLKYV-QEDSCQRGVYGRLVCT 78

  Fly    67 NYRI-FLSKQSTGYE--------------TYVPLGLIESV------QVRDLF--------QLIVN 102
            :::| ||..:.:..:              ..|||..::.:      :.:.||        :|:::
Mouse    79 DFKISFLGDEDSALDNGGEAQFKNKIIGVNDVPLHCVDQIYGVFDEKKKPLFGQLKKYPEKLVIH 143

  Fly   103 CKDASTVR-C-SFPSAEQCSDWQRRIHLMIGV------PESLETLFAFPFYSWTCDVLGSGNGSG 159
            |||...:. | .:...|:..      .::.|:      |:.|:.||.|   |:...|.|:...|.
Mouse   144 CKDLRVLHFCLRYTKEEEVK------RIVSGIIHHTQSPKLLKRLFLF---SYAAAVHGTATDSR 199

  Fly   160 IVSAQANGNGLIAKDRCLTLHNGLAKPTANVTASNPLPDPASETISAAMSNRLQRSVRYESDFKN 224
            ..:...:    ..||.|..|                              .|.:.||:|
Mouse   200 NCTVMFD----TPKDWCWEL------------------------------ERTKGSVKY------ 224

  Fly   225 EVARLGFDLKGSWRISTANADFKLCPSYPPKLLVPCCITDEMLHNVANFRGSRRLPAVVWRHQKS 289
                         |..:.|..:::....|...:||..:.::   :|..|:| ..:|...|.....
Mouse   225 -------------RTVSVNEGYRVSDRLPAYFVVPTPLPED---DVRRFQG-HGIPIWCWSCHNG 272

  Fly   290 GAILARCSQPEVGWLGWRNTRDE---QLLKALADACAFDRGEHARHSTCANAKAQPTKGSKETNG 351
            .|:|...:.|:        .:|:   |:.|:..|..         :.|......:..|
Mouse   273 SALLKMSALPK--------EQDDGALQVQKSFLDGI---------YKTIHRPPYEMVK------- 313

  Fly   352 QSGLSGKSSPSLDDSSHEELTLDEI-------KKILIVDARSYTSAVTNRARGGGCECIEYYPCA 409
                       .:|.|...|:|.||       |::.::|..|
Mouse   314 -----------TEDLSSNFLSLQEIQSAYCKFKQLFLIDNSS----------------------- 344

  Fly   410 EIEFMNLGNIHAIRKSFHAVRQLCASSPDDPNWYGQLEKTMWMQHLSGLLGATMTVVHTIEKNGR 474
              ||.:                      .|..|:..||.:.|:..:...|...:.:...:|....
Mouse   345 --EFWD----------------------TDIKWFSLLESSSWLDIIRRCLKKAIEITECLEAQNV 385

  Fly   475 PVLVHCSDGWDRTPQIVATAQLCLDPYYRTVEGFRVLVEREWLNFGHKFADRSGNGPNSDEVNER 539
            .||:...:..|....:.:..|:.:|.:.||..||:.|:::||:..||.|.||..:...||:  |.
Mouse   386 NVLLLEENASDLCCLLSSLVQVMMDAHCRTRTGFQSLIQKEWVMGGHSFLDRCNHLHQSDK--EE 448

  Fly   540 CPVFLQWLDLVHQIHRQYPCSFEFSISYLIKLAQHSLSCLFGTFLCNSLRERIEN---------- 594
            .|:||.:||.|.|:..|||.:|||:.:||..|:......:|.||..||..::..|
Mouse   449 VPIFLLFLDCVWQLVHQYPPAFEFTETYLTVLSDSLYIPIFSTFFFNSPHQKDTNMGRENLDAQS 513

  Fly   595 ------SVFDRTFSVWPFLAETMYRNPLYKHETEKVLWPAHSVRFLYFWSDVYLGSLGNKNGTDL 653
                  :|:|.:....| .|:|:.|||||..:.:.........||              |:...|
Mouse   514 KPLTLLTVWDWSVQFEP-KAQTLLRNPLYVEKPKLDRGQQKGSRF--------------KHQRQL 563

  Fly   654 PL-LSNERQSGHNGLMAKTRSSEDLTTNELGQSTISR--RSSD 693
            .| |:..:.|...|...:  .::.|..|.||: .||:  .|||
Mouse   564 SLPLTQSKSSPKRGFFRE--ETDHLIKNLLGK-RISKLINSSD 603

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3632	NP_001096996.1	PH-like	35..147	CDD:473070	30/157 (19%)
		Myotub-related	221..591	CDD:461958	78/379 (21%)
		FYVE_MTMR4	1162..1221	CDD:277272
Mtmr12	NP_766546.1	PH-like	26..204	CDD:473070	37/187 (20%)
		PTP-MTMR12	260..462	CDD:350442	55/285 (19%)
		Interaction with MTM1. /evidence=ECO:0000250	449..558		34/123 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	548..575		7/40 (18%)
		3-PAP	559..685	CDD:463634	14/48 (29%)