DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3632 and Mtmr6

DIOPT Version :9

Sequence 1:	NP_001096996.1	Gene:	CG3632 / 32589	FlyBaseID:	FBgn0030735	Length:	1250	Species:	Drosophila melanogaster
Sequence 2:	XP_017171460.1	Gene:	Mtmr6 / 219135	MGIID:	2145637	Length:	655	Species:	Mus musculus

Alignment Length:	727	Identity:	202/727 - (27%)
Similarity:	324/727 - (44%)	Gaps:	131/727 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 ESIKYLGR--TDD----GILAL-SNYRIFLSKQSTGYETYVPLGLIESVQVRDL----FQLIVNC 103
            |.:|.|.|  |::    |.|.| :.:.:|:..|..  ||::....|.||:...|    ..|::.|
Mouse    10 EQVKLLDRFSTNNKSLTGTLYLTATHLLFIDAQQK--ETWILHHHIASVEKLALTTSGCPLVIQC 72

  Fly   104 KDASTVRCSFPSAEQCSDWQRRIHLMIGVPESLETLFAFPFYSWTCDVLGSGNGSGIVSAQANGN 168
            |:...|....|....|.|....: |.:......|.|:||.:           |.....:.:.||.
Mouse    73 KNFRIVHFIVPRERDCHDIYNSL-LQLSKQAKYEDLYAFSY-----------NPKQNDTERRNGW 125

  Fly   169 GLIAKDRCLTLHNGLAKPTANVTASNPLPDPASETISAAMSNRLQRSVRYESDFKNEVARLGFDL 233
            .||                                                 |...|..|:|..
Mouse   126 QLI-------------------------------------------------DLAAEYERMGVP- 140

  Fly   234 KGSWRISTANADFKLCPSYPPKLLVPCCITDEMLHNVANFRGSRRLPAVVWRHQKSGAILARCSQ 298
            ..:|::|.||.::|:|.:||.:|.||...:..::...:|||...|||.:.:..|.:.|.:.||||
Mouse   141 NANWQLSDANREYKVCETYPRELYVPRTASRPVIVGSSNFRSKGRLPVLSYCRQGTEAAICRCSQ 205

  Fly   299 PEVGWLGWRNTRDEQLLKALADACAFDRGEHARHSTCANAKAQPTKGSKETNGQSGLSGKSSPSL 363
            |..|:.. |...||.||:|::.|...:|..:. ..|....:.|....:::..|:. :...||...
Mouse   206 PLSGFSA-RCLEDEHLLQAISKANPGNRYMYV-VDTRPKHRMQSWWDTQKDIGRI-IVRISSKIW 267

  Fly   364 DDSSHEELTLDEIKKILIVDARSYTSAVTNRARGGGCECIEYYPCAEIEFMNLGNIHAIRKSFHA 428
            :|           :||...|.|...:|:.|||.|.|.|..:.|.....:|:.:.|||.:|.|...
Mouse   268 ND-----------EKIRESDERKRLNAIANRAAGKGYENEDNYSNIRFQFVGIENIHVMRSSLQK 321

  Fly   429 VRQLCASSPDDPN-WYGQLEKTMWMQHLSGLLGATMTVVHTIEKNGRPVLVHCSDGWDRTPQIVA 492
            :.::..|.....| :|..||.:.|::|:..:|.|.:.:...|......||||||||||||.|:.:
Mouse   322 LLEVNGSKGLSVNDFYSGLESSGWLRHIKAVLDAAIFLAKAIVVENASVLVHCSDGWDRTSQVCS 386

  Fly   493 TAQLCLDPYYRTVEGFRVLVEREWLNFGHKFADRSGNGPNSDEVNERCPVFLQWLDLVHQIHRQY 557
            ...|.||.||||::||.||:|::|::|||||::|.|:  ...:..|..|||.|:|:.|..:.:|:
Mouse   387 LGSLLLDSYYRTMKGFMVLIEKDWISFGHKFSERCGH--LDGDPREVSPVFTQFLECVWHLTQQF 449

  Fly   558 PCSFEFSISYLIKLAQHSLSCLFGTFLCNSLRERIENSVFDRTFSVWPFLAE--TMYRNPLYKHE 620
            |.:|||:.::|:::.:|..||.||.||.|..:||.|..:.::|:|:||||.:  ..|.||||..:
Mouse   450 PQAFEFNEAFLLQIHEHIHSCQFGNFLGNCQKEREELRLKEKTYSLWPFLLDDKKKYLNPLYSSK 514

  Fly   621 TEK--VLWPAHSVRFLYFWSDVY-------------LGSLGNKNGTDLPLLSNERQSGHNGLMAK 670
            :::  ||.|..:.....||.::|             |..:.|.|..     |.:.:.....|.||
Mouse   515 SQRLTVLEPNTASFNFKFWRNMYHQFDRTLHPRQSVLSIIMNMNEQ-----SKQLEEDIKDLEAK 574

  Fly   671 TRSSED-LTTNEL-----GQSTISRRS---SDPNLTVESIVTDCFNANSNSMFDIRSEANNSVSE 726
            .:..:: :.|.||     .:|...:.|   .:|:|..   |.|...|...|     |.|:|...:
Mouse   575 IKQCKNGILTKELLHAVHPESPALKTSLCLKEPSLLP---VKDTLRAIEGS-----SPADNRYCD 631

  Fly   727 NVQESVKDSKEV 738
            ..:|..|....|
Mouse   632 YAEEFSKSEPTV 643

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3632	NP_001096996.1	PH-like	35..147	CDD:302622	28/107 (26%)
		Myotub-related	221..590	CDD:284109	125/369 (34%)
		FYVE_MTMR4	1162..1221	CDD:277272
Mtmr6	XP_017171460.1	PH-GRAM_MTMR6	1..101	CDD:270151	24/93 (26%)
Mtmr6	XP_017171460.1	PTP_DSP_cys	130..469	CDD:391942	117/355 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846006
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D824298at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.850