DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3632 and Mtmr11

DIOPT Version :9

Sequence 1:	NP_001096996.1	Gene:	CG3632 / 32589	FlyBaseID:	FBgn0030735	Length:	1250	Species:	Drosophila melanogaster
Sequence 2:	NP_852074.2	Gene:	Mtmr11 / 194126	MGIID:	2652817	Length:	700	Species:	Mus musculus

Alignment Length:	730	Identity:	155/730 - (21%)
Similarity:	242/730 - (33%)	Gaps:	260/730 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 LAGESI--------KYLGRTDDGILALSNYRI------FLSKQSTGYET-----YVPLGLIESVQ 92
            |.||.|        |..|....|.|..:|:|:      :..||.|...:     .:.:|.:|:|.
Mouse    51 LPGEHILAWAPGRRKGPGLDLPGTLICTNFRVTFQPCGWQRKQDTPLSSENDFALINIGRLEAVS 115

  Fly    93 VRDLFQ--------------LIVNCKDASTVRCSFPSAEQCSDWQRRIHLMIGV-PESLETLFAF 142
            .....|              |:::.:|...:|..|.:.              |: |::.:...|
Mouse   116 GLSRVQLLRPGSQLKFIPEELLLHGRDFRLLRVGFEAG--------------GLAPQAFQVTMA- 165

  Fly   143 PFYSWTCDVLGSGNGSGIVSAQANGNGLIAKDRCLTLHNGLAKPTANVTASNPLPDPASETISAA 207
                             |:.|:|. :..:.:.|.:||     .....|:.|...|.|..||:.
Mouse   166 -----------------IIQARAQ-SSQVQQYRGITL-----SKVGKVSGSRKPPIPLLETLE-- 205

  Fly   208 MSNRLQRSVRYESDFKNEVARLGFDLKGSWRISTANADFKLCPSYPPKLLVPCCITD-EMLHNVA 271
                     .:|::.|.:.||       .||:||.|..|.:..|......||..|.| |:....|
Mouse   206 ---------DWETECKKQGAR-------GWRVSTVNERFDVATSLSGYFWVPNRILDSEVRRAFA 254

  Fly   272 NFRGSRRLPAVVWRHQKSGAILARC------SQPEVGWLGWRNTRDEQLLKALADACAFDRGEHA 330
            :|...|. |.:.| |...|:.|.||      |.|        |..|.:.::::..|
Mouse   255 HFHQGRG-PRLSW-HHPGGSDLLRCGGFYIASDP--------NKEDIRAVESMLQA--------- 300

  Fly   331 RHSTCANAKAQPTKGSKETNGQSGLSGKSSPSLDDSSHEELTLDEIKKILIVDARSYTSAVTNRA 395
                                      |.|...|.:      |:||:..:
Mouse   301 --------------------------GHSDVVLVE------TMDEMPSL---------------- 317

  Fly   396 RGGGCECIEYYPCAEIEFMNLGNIHAIRKSFHAVRQLCA--SSPDDPNWYGQLEKTMWMQHLSGL 458
                         |:|:..:|           .:|.||.  ||..:..|...||.|.|:.::...
Mouse   318 -------------ADIQLAHL-----------KLRALCLPDSSVAEDKWLSALEGTRWLDYVRSC 358

  Fly   459 LGATMTVVHTIEKNGRPVLVHCSDGWDRTPQIVATAQLCLDPYYRTVEGFRVLVEREWLNFGHKF 523
            |.....:...:....|.|::......|....:.:..||.|.|..||:.||:.||:|||:..||.|
Mouse   359 LRKASDISVLVTSRVRSVVLQELGDRDFNGLLSSLVQLLLAPEARTLFGFQSLVQREWVAAGHPF 423

  Fly   524 ADRSGNGPNSDEVNERCPVFLQWLDLVHQIHRQYPCSFEFSISYLIKL-----AQHSLSCLFGTF 583
            ..|.|:...|:|    .|||..:||...|:.:|:|..||||..:|:.|     ...:|     ||
Mouse   424 LTRLGDTGASEE----APVFPLFLDCAWQLLQQFPAEFEFSEFFLLALHDSIRVPDTL-----TF 479

  Fly   584 LCNSLRER---------------------IENSVFDRTFSVWPFLAE------TMYRNPLY---- 617
            |.|:..||                     :..|..:...|||.:...      :.:.||.|
Mouse   480 LRNTPWERGKKSGQFNSYTQVYTPEYSQPLAGSSANLHLSVWDWDLRYSKEQISQFLNPGYDPEH 544

  Fly   618 ------KHETEKVLWPAHSVRFLYFWSDVYLGSLGNKNGTDLPLLSNERQSGHNGLMA------- 669
                  ..:.:.::.|...       |.::|.|    .||..||.........:.|:|
Mouse   545 CPDSRFSRQQQSLMVPGPP-------SSMWLFS----RGTLTPLNQLCPWQDSSSLLAVSSHWLP 598

  Fly   670 -KTRSSEDLTTNELG 683
             ..||||.|...|.|
Mouse   599 RPARSSESLADQEWG 613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3632	NP_001096996.1	PH-like	35..147	CDD:302622	24/133 (18%)
		Myotub-related	221..590	CDD:284109	92/382 (24%)
		FYVE_MTMR4	1162..1221	CDD:277272
Mtmr11	NP_852074.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..39
		PH-like	51..165	CDD:302622	23/127 (18%)
		PTPc	195..469	CDD:304379	92/386 (24%)
		3-PAP	553..683	CDD:289355	17/72 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846020
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740