Protein Alignment CG3632 and mtm-3

DIOPT Version :10

• Sequence 1: NP_001096996.1
• Gene: CG3632 / 32589
• FlyBaseID: FBgn0030735
• Length: 1250
• Species: Drosophila melanogaster
• Sequence 2: NP_001022794.2
• Gene: mtm-3 / 175490
• WormBaseID: WBGene00003476
• Length: 1006
• Species: Caenorhabditis elegans
• Alignment Length: 1134
• Identity: 282/1134 - (24%)
• Similarity: 456/1134 - (40%)
• Gaps: 298/1134 - (26%)

  Fly    13 GSPPPSICFIRAAESYPKSQ---MEKEDSQLFVPFQELAGESIKYLGRTDDGILALSNYRIFLSK 74
            |.||.:    ..:|:.|::.   :|....:...|..:|....|      :.|.|.::|:||.:
 Worm    75 GMPPVT----EESENMPQNYETVVELLPGEERAPINKLTEFPI------EGGSLFVTNFRIVV-- 127

  Fly    75 QSTGYETYVPLGLIESVQVRDLFQ-LIVNCKDASTVRCSFPSAEQCSDWQRRIHLMIGVPESLET 138
                        :::..:|.:..: |:...:|...:..:.|:.         |||.:    .:..
 Worm   128 ------------ILKDKEVEEALRFLVFPLQDIEQIDLAIPAF---------IHLSL----KIGR 167

  Fly   139 LFAFPFYSWTCDVLGSGNGSGIVSAQANGNGLIAKDRCL------TLHNGLAKPTANVTASNPLP 197
            :|...|.:                         |:|..|      |....|.:|.:::..|.|..
 Worm   168 MFTICFKT-------------------------AEDAALVHKILYTAFQRLNRPISSIYTSRPQD 207

  Fly   198 DPASETISAAMS------------NRLQRSVRYES------DFKNEVARLGFDLKG---SWRIST 241
            ..:..|.:...|            :.|.|..:..|      ....|:..:.|:..|   .::||:
 Worm   208 WTSKNTDNPMQSLNAFAWKFSEAVDELDRDGKLPSWLLRADSVAQEITHIDFNRLGMSEHFQISS 272

  Fly   242 ANADFKLCPSYPPKLLVPCCITDEMLHNVANFRGSRRLPAVVWRHQKSGAILARCSQPEVGWLGW 306
            .|.:|::||:||.|::||..|||:.:...|.:|...|.|||:||.:|:.|:|.|.|||:||.|.|
 Worm   273 VNENFEVCPTYPEKIIVPKGITDDDIRKGAPYRSIGRFPAVIWRCRKTRAVLMRSSQPQVGILSW 337

  Fly   307 RNTRDEQLLKALADACAFDRGEHARHSTCANAKAQPTKGSKETNGQSGLSGKSSPSLDDSSHEEL 371
            ||..||:::            |.|       .||...:|
 Worm   338 RNPTDEKII------------EEA-------VKASRIEG-------------------------- 357

  Fly   372 TLDEIKKILIVDARSYTSAVTNRARGGGCECIEYYPCAEIEFMNLGNIHAIRKSFHAVRQLCASS 436
              :|.|:.:|:|||.||||..||||.||.|..|||..|::||:.|.||||:|.||:.||.:..:.
 Worm   358 --EEKKQFIIMDARGYTSAFANRARSGGFENTEYYQQAKLEFLGLPNIHAVRGSFNNVRTMLHNL 420

  Fly   437 PDDPNWYGQLEKTMWMQHLSGLLGATMTVVHTIEKNGRPVLVHCSDGWDRTPQIVATAQLCLDPY 501
            ..:......|:.|.|:.:||.||.........:.| |..||||||||||||.|:...|::.||.|
 Worm   421 GPNEQLLTSLQTTGWLLNLSNLLVNAANCADHLSK-GHSVLVHCSDGWDRTTQVTTLAKIMLDEY 484

  Fly   502 YRTVEGFRVLVEREWLNFGHKFADRS----GNGPNSDEVNERCPVFLQWLDLVHQIHRQYPCSFE 562
            ||||:||..|:.|:|:.||||..||.    ||...||   ||.|||||:|:.|..:.|:.|..|:
 Worm   485 YRTVKGFEELIRRDWIAFGHKLYDRQLVAFGNWGTSD---ERSPVFLQFLEAVRHLQREQPTLFQ 546

  Fly   563 FSISYLIKLAQHSLSCLFGTFLCNSLRERIE------NSVFDRTFSVWPFLA---ETMYRNPLYK 618
            |:.:||||||:|:.|.|||:||.||.:||.|      .::.|    :|.|:.   |........:
 Worm   547 FTHAYLIKLAKHAYSGLFGSFLFNSHKERREAMEKCKGTLVD----IWRFIGPHNEEYVNQSFDE 607

  Fly   619 HETEKVLWPAHSVRFLYFWSDV-------YLGSLGNKNGTDLPLLSNERQSGHNGLMAKTRSSED 676
            |.|..|.....||..|..|.:|       |......|....|...:....:..:..:.|::|||.
 Worm   608 HYTGAVKPVNVSVINLRVWHEVFADEEEHYTQIFSPKEERPLSGCTTPMNTSTSTNLVKSKSSES 672

  Fly   677 LTTNELGQSTISRRSSDPNLTVESIVTDCFNANSNSMFDIRSEANNSVSENVQESVKDSKEVELD 741
            :  |.|.....::.||..:.|..:..:|  |.||..|          .:..:|:|:...|...:.
 Worm   673 I--NSLNVDGSAKESSQQHPTCSTTPSD--NTNSLPM----------STSFIQQSLYQPKVRGVA 723

  Fly   742 VTDATEVGPCGRSNNPIPDFHND-QSTASKRDILEVE---------SQTQRRSSLESSQLIPGSV 796
            ..|          .:.:..|.:| |:...|::.|..|         .:.:||:.|:::::.||..
 Worm   724 AID----------RDGVIRFEDDEQAMLRKKNKLRAEEIRRKDEKIEELRRRAVLDTNKVSPGQR 778

  Fly   797 FIFGSSENDKNAVPSESEESLATSQKLN------------SESGRPFFIFGSSENDQSPVPLKSE 849
            ..:..|:.:...........::....:|            .|||...:    .:.:.:.:.:..|
 Worm   779 QSYSESDVETTGTLERVMSDVSMVDPVNELPHFKPNTTWEGESGHCAY----CKKEFNKLSVYVE 839

  Fly   850 DTS----DISRALWHGAIETSTDTLIPAEPVQKPNSDNSSRDHITSPTMELVSGDRKLESTSTVQ 910
            |..    :..|.:.....:.....:...:.|||...| |..|.:....::|.|     .||:|..
 Worm   840 DRQHHCRNCGRVVCEDCSKNRFSVIEEGKSVQKRACD-SCYDSMHETDLKLSS-----SSTTTTS 898

  Fly   911 ASKISQSYNNLPKV---------HIRPNAVICPQRVDAFPHHLDLQVPRETTGNPDRCKPEKLAK 966
            :|...::.:|:|.:         ::..||:                        ||....||.|:
 Worm   899 SSTKIENDSNVPGLDNNSDNVSENVSENAI------------------------PDIIVEEKEAE 939

  Fly   967 DANANANANGSLLASDGYNGEESLFISPD--------LQRFVGQSPFDAPSTGGRIRRNTFGSSY 1023
            |....|.                   ||.        |:.|:..||..:      :|:|   ..:
 Worm   940 DPIKEAE-------------------SPSKETKCPKTLRNFISFSPKSS------MRKN---KVH 976

  Fly  1024 SRD-MKFTAENGSAHQFPSSGIISLPPTP 1051
            ||| :|...|..|:.|..|..::.:...|
 Worm   977 SRDPLKSIDEGSSSQQAESDDVLDVNEQP 1005

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3632	NP_001096996.1	PH-like	35..147	CDD:473070	17/112 (15%)
		Myotub-related	221..591	CDD:461958	151/376 (40%)
		FYVE_MTMR4	1162..1221	CDD:277272
mtm-3	NP_001022794.2	Myotub-related	258..576	CDD:461958	151/368 (41%)
		FYVE	814..883	CDD:214499	12/73 (16%)