DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3632 and mtm-3

DIOPT Version :9

Sequence 1:	NP_001096996.1	Gene:	CG3632 / 32589	FlyBaseID:	FBgn0030735	Length:	1250	Species:	Drosophila melanogaster
Sequence 2:	NP_001022794.2	Gene:	mtm-3 / 175490	WormBaseID:	WBGene00003476	Length:	1006	Species:	Caenorhabditis elegans

Alignment Length:	1134	Identity:	282/1134 - (24%)
Similarity:	456/1134 - (40%)	Gaps:	298/1134 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 GSPPPSICFIRAAESYPKSQ---MEKEDSQLFVPFQELAGESIKYLGRTDDGILALSNYRIFLSK 74
            |.||.:    ..:|:.|::.   :|....:...|..:|....|      :.|.|.::|:||.:
Worm    75 GMPPVT----EESENMPQNYETVVELLPGEERAPINKLTEFPI------EGGSLFVTNFRIVV-- 127

  Fly    75 QSTGYETYVPLGLIESVQVRDLFQ-LIVNCKDASTVRCSFPSAEQCSDWQRRIHLMIGVPESLET 138
                        :::..:|.:..: |:...:|...:..:.|:.         |||.:    .:..
Worm   128 ------------ILKDKEVEEALRFLVFPLQDIEQIDLAIPAF---------IHLSL----KIGR 167

  Fly   139 LFAFPFYSWTCDVLGSGNGSGIVSAQANGNGLIAKDRCL------TLHNGLAKPTANVTASNPLP 197
            :|...|.:                         |:|..|      |....|.:|.:::..|.|..
Worm   168 MFTICFKT-------------------------AEDAALVHKILYTAFQRLNRPISSIYTSRPQD 207

  Fly   198 DPASETISAAMS------------NRLQRSVRYES------DFKNEVARLGFDLKG---SWRIST 241
            ..:..|.:...|            :.|.|..:..|      ....|:..:.|:..|   .::||:
Worm   208 WTSKNTDNPMQSLNAFAWKFSEAVDELDRDGKLPSWLLRADSVAQEITHIDFNRLGMSEHFQISS 272

  Fly   242 ANADFKLCPSYPPKLLVPCCITDEMLHNVANFRGSRRLPAVVWRHQKSGAILARCSQPEVGWLGW 306
            .|.:|::||:||.|::||..|||:.:...|.:|...|.|||:||.:|:.|:|.|.|||:||.|.|
Worm   273 VNENFEVCPTYPEKIIVPKGITDDDIRKGAPYRSIGRFPAVIWRCRKTRAVLMRSSQPQVGILSW 337

  Fly   307 RNTRDEQLLKALADACAFDRGEHARHSTCANAKAQPTKGSKETNGQSGLSGKSSPSLDDSSHEEL 371
            ||..||:::            |.|       .||...:|
Worm   338 RNPTDEKII------------EEA-------VKASRIEG-------------------------- 357

  Fly   372 TLDEIKKILIVDARSYTSAVTNRARGGGCECIEYYPCAEIEFMNLGNIHAIRKSFHAVRQLCASS 436
              :|.|:.:|:|||.||||..||||.||.|..|||..|::||:.|.||||:|.||:.||.:..:.
Worm   358 --EEKKQFIIMDARGYTSAFANRARSGGFENTEYYQQAKLEFLGLPNIHAVRGSFNNVRTMLHNL 420

  Fly   437 PDDPNWYGQLEKTMWMQHLSGLLGATMTVVHTIEKNGRPVLVHCSDGWDRTPQIVATAQLCLDPY 501
            ..:......|:.|.|:.:||.||.........:.| |..||||||||||||.|:...|::.||.|
Worm   421 GPNEQLLTSLQTTGWLLNLSNLLVNAANCADHLSK-GHSVLVHCSDGWDRTTQVTTLAKIMLDEY 484

  Fly   502 YRTVEGFRVLVEREWLNFGHKFADRS----GNGPNSDEVNERCPVFLQWLDLVHQIHRQYPCSFE 562
            ||||:||..|:.|:|:.||||..||.    ||...||   ||.|||||:|:.|..:.|:.|..|:
Worm   485 YRTVKGFEELIRRDWIAFGHKLYDRQLVAFGNWGTSD---ERSPVFLQFLEAVRHLQREQPTLFQ 546

  Fly   563 FSISYLIKLAQHSLSCLFGTFLCNSLRERIE------NSVFDRTFSVWPFLA---ETMYRNPLYK 618
            |:.:||||||:|:.|.|||:||.||.:||.|      .::.|    :|.|:.   |........:
Worm   547 FTHAYLIKLAKHAYSGLFGSFLFNSHKERREAMEKCKGTLVD----IWRFIGPHNEEYVNQSFDE 607

  Fly   619 HETEKVLWPAHSVRFLYFWSDV-------YLGSLGNKNGTDLPLLSNERQSGHNGLMAKTRSSED 676
            |.|..|.....||..|..|.:|       |......|....|...:....:..:..:.|::|||.
Worm   608 HYTGAVKPVNVSVINLRVWHEVFADEEEHYTQIFSPKEERPLSGCTTPMNTSTSTNLVKSKSSES 672

  Fly   677 LTTNELGQSTISRRSSDPNLTVESIVTDCFNANSNSMFDIRSEANNSVSENVQESVKDSKEVELD 741
            :  |.|.....::.||..:.|..:..:|  |.||..|          .:..:|:|:...|...:.
Worm   673 I--NSLNVDGSAKESSQQHPTCSTTPSD--NTNSLPM----------STSFIQQSLYQPKVRGVA 723

  Fly   742 VTDATEVGPCGRSNNPIPDFHND-QSTASKRDILEVE---------SQTQRRSSLESSQLIPGSV 796
            ..|          .:.:..|.:| |:...|::.|..|         .:.:||:.|:::::.||..
Worm   724 AID----------RDGVIRFEDDEQAMLRKKNKLRAEEIRRKDEKIEELRRRAVLDTNKVSPGQR 778

  Fly   797 FIFGSSENDKNAVPSESEESLATSQKLN------------SESGRPFFIFGSSENDQSPVPLKSE 849
            ..:..|:.:...........::....:|            .|||...:    .:.:.:.:.:..|
Worm   779 QSYSESDVETTGTLERVMSDVSMVDPVNELPHFKPNTTWEGESGHCAY----CKKEFNKLSVYVE 839

  Fly   850 DTS----DISRALWHGAIETSTDTLIPAEPVQKPNSDNSSRDHITSPTMELVSGDRKLESTSTVQ 910
            |..    :..|.:.....:.....:...:.|||...| |..|.:....::|.|     .||:|..
Worm   840 DRQHHCRNCGRVVCEDCSKNRFSVIEEGKSVQKRACD-SCYDSMHETDLKLSS-----SSTTTTS 898

  Fly   911 ASKISQSYNNLPKV---------HIRPNAVICPQRVDAFPHHLDLQVPRETTGNPDRCKPEKLAK 966
            :|...::.:|:|.:         ::..||:                        ||....||.|:
Worm   899 SSTKIENDSNVPGLDNNSDNVSENVSENAI------------------------PDIIVEEKEAE 939

  Fly   967 DANANANANGSLLASDGYNGEESLFISPD--------LQRFVGQSPFDAPSTGGRIRRNTFGSSY 1023
            |....|.                   ||.        |:.|:..||..:      :|:|   ..:
Worm   940 DPIKEAE-------------------SPSKETKCPKTLRNFISFSPKSS------MRKN---KVH 976

  Fly  1024 SRD-MKFTAENGSAHQFPSSGIISLPPTP 1051
            ||| :|...|..|:.|..|..::.:...|
Worm   977 SRDPLKSIDEGSSSQQAESDDVLDVNEQP 1005

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3632	NP_001096996.1	PH-like	35..147	CDD:302622	17/112 (15%)
		Myotub-related	221..590	CDD:284109	151/375 (40%)
		FYVE_MTMR4	1162..1221	CDD:277272
mtm-3	NP_001022794.2	Myotub-related	258..574	CDD:284109	150/366 (41%)
mtm-3	NP_001022794.2	FYVE	814..883	CDD:214499	12/73 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160160989
Domainoid	1	1.000	260	1.000	Domainoid score	I1065
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	314	1.000	Inparanoid score	I1536
Isobase	1	0.950	-	0	Normalized mean entropy	S3513
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D191120at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto18599
orthoMCL	1	0.900	-	-		OOG6_105196
Panther	1	1.100	-	-	LDO	PTHR10807
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4944
SonicParanoid	1	1.000	-	-		X2890
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.880