DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3632 and Mtmr4

DIOPT Version :9

Sequence 1:	NP_001096996.1	Gene:	CG3632 / 32589	FlyBaseID:	FBgn0030735	Length:	1250	Species:	Drosophila melanogaster
Sequence 2:	XP_006532446.1	Gene:	Mtmr4 / 170749	MGIID:	2180699	Length:	1204	Species:	Mus musculus

Alignment Length:	1326	Identity:	450/1326 - (33%)
Similarity:	644/1326 - (48%)	Gaps:	280/1326 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 PPSICFIRAAESYPKSQMEKEDSQLFVPFQELAGESIKYLGRTDDGILALSNYRIFLS-KQSTGY 79
            |||:.:|:|.:.:|..::.||:..|.|||..|.||.:::|||..|.::|:||||:.:. |.|.
Mouse    20 PPSLEYIQAKDLFPPKELVKEEENLQVPFTVLQGEGVEFLGRATDALIAISNYRLHIKFKDSV-- 82

  Fly    80 ETYVPLGLIESVQVRDLFQLIVNCKDASTVRCSFPSAEQCSDWQRRIHLMIGVPESLETLFAFPF 144
             ..|||.:|:||:.||:|||.:.|||:..|||.|.:.:||.:|..|:......|...|.||||.:
Mouse    83 -INVPLRMIDSVESRDMFQLHIACKDSKVVRCHFSTFKQCQEWLSRLSRATARPAKPEDLFAFAY 146

  Fly   145 YSWTCDVLGSGNGSGIVSAQANGNGLIAKDRCLTLHNGLAKPTANVTASNPLPDPASETISAAMS 209
            ::|..                   ||..:|:    |..|.:|..::..
Mouse   147 HAWCL-------------------GLTEEDQ----HTHLCQPGEHIRC----------------- 171

  Fly   210 NRLQRSVRYESDFKNEVARLGFDLKGSWRISTANADFKLCPSYPPKLLVPCCITDEMLHNVANFR 274
                   |.|:    |:||:||||:..||:|..|:::|||||||.|||||..|||:.|.|||:||
Mouse   172 -------RQEA----ELARMGFDLQNVWRVSHINSNYKLCPSYPQKLLVPVWITDKELENVASFR 225

  Fly   275 GSRRLPAVVWRHQKSGAILARCSQPEVGWLGWRNTRDEQLLKALADACAFDRGEHARH---STCA 336
            ..:|:|.||:||.::||.:|||||||:.|.||||..||.|:.::|.|||.|.|..|..   ||..
Mouse   226 SWKRIPVVVYRHLRNGAAIARCSQPEISWWGWRNADDEYLVTSIAKACALDPGTRASGGSLSTGT 290

  Fly   337 N--AKAQPTKGSKETNGQSGLSGKSSPSLDDSSHEELTLDEIKKILIVDARSYTSAVTNRARGGG 399
            |  ::|..|.........||:...::|               :|:||:||||||:||.|||:|||
Mouse   291 NDASEACDTDFDSSLTACSGVESTAAP---------------QKLLILDARSYTAAVANRAKGGG 340

  Fly   400 CECIEYYPCAEIEFMNLGNIHAIRKSFHAVRQLCASSPDDPNWYGQLEKTMWMQHLSGLLGATMT 464
            |||.||||..|:.||.:.||||||.||..:|.:|:..||..||...||.|.|:||||.:|.|.:.
Mouse   341 CECEEYYPNCEVLFMGMANIHAIRNSFQYLRAVCSQMPDPSNWLSALESTKWLQHLSVMLKAAVL 405

  Fly   465 VVHTIEKNGRPVLVHCSDGWDRTPQIVATAQLCLDPYYRTVEGFRVLVEREWLNFGHKFADRSGN 529
            |.:|:::.||||||||||||||||||||.|::.|||||||:|||:||||.:||:|||||.||.|:
Mouse   406 VANTVDREGRPVLVHCSDGWDRTPQIVALAKILLDPYYRTLEGFQVLVESDWLDFGHKFGDRCGH 470

  Fly   530 GPNSDEVNERCPVFLQWLDLVHQIHRQYPCSFEFSISYLIKLAQHSLSCLFGTFLCNSLRERIEN 594
            ..|:::.||:|||||||||.|||:.:|:||.|||:.::|:||.||:.|||:||||.|:..||.:.
Mouse   471 QENAEDQNEQCPVFLQWLDSVHQLLKQFPCLFEFNEAFLVKLVQHTYSCLYGTFLANNPCEREKR 535

  Fly   595 SVFDRTFSVWPFL--AETMYRNPLYKHETEKVLWPAHSVRFLYFWSDVYLG-----SLGNKNGTD 652
            :::.||.|||..|  ....:.|.||...::.||.|...||.|:.|:.|||.     :||.:| .|
Mouse   536 NIYKRTCSVWALLRAGNKNFHNFLYTPGSDVVLHPVCHVRALHLWTAVYLPASSPCTLGEEN-MD 599

  Fly   653 L---PLLSNERQSGHN-GLMAKTRSSEDLTTNELGQSTISRRSSDPNLTVESIVTDCFNANSNSM 713
            |   |:..::..||.: ..:.||||.:||.:.....|.::|.||||||            |::|.
Mouse   600 LYLSPVAQSQEFSGRSLDRLPKTRSMDDLLSACDTSSPLTRTSSDPNL------------NNHSQ 652

  Fly   714 FDIRS--EANNSVSENVQESVKDSKEVELDVTDATEVGPCGRSNNPIPDFHNDQSTASKRDILEV 776
             ::|.  |..:|..|.. |:|.||......:|    ||..|.. .|:|        :|:::.|..
Mouse   653 -EVRGSLEPWHSSPEGA-ETVIDSGVGSPQLT----VGEMGLP-PPLP--------SSQKEYLSN 702

  Fly   777 ESQTQRRSSLESSQLIPGSVFIFGSSENDKNAVPSESEESLATSQKLNSESGRPFFIFGSSENDQ 841
            :.....:|...|.:|:..|| .:....|..:....|..|:||.......|.||      :|:...
Mouse   703 KPFKGHKSCSLSYKLLNTSV-SWEMKSNTSDIKVLEETEALAPDPSAQEEQGR------TSDGLG 760

  Fly   842 SPVP--LKSEDTSDIS--RALWHGAIETSTDTLIPAEPVQKPNSDNSSRDHITSPTMELVSGDRK 902
            .|..  |:.|..|.:.  .:...||.:      .| ||.|.|.:....:.|:.|  |::
Mouse   761 KPPEQFLEKEAVSSLCSVSSKCGGACD------FP-EPPQDPLTGTPQQPHLDS--MQI------ 810

  Fly   903 LESTSTVQASKISQSYNNLPKVHIR---PNAVICPQRVDAFPHHLDLQVPRETTGNPDRCKPEKL 964
              |.|.........|..|.|.|..:   ||..:..|           ..|..|.....:.:|..:
Mouse   811 --SPSRCTPDHSQGSLCNPPSVASQTPEPNTDLLSQ-----------DPPGSTASISHQEQPSSV 862

  Fly   965 ------AKDANANANANGSLLASDGYNGEESLFISPDLQRFVGQSPFDAPSTGGRIRRNTFGSSY 1023
                  .:||....:.||.||.:               .|| |:.|.:       :.|.....|.
Mouse   863 PDLIYKKEDAGKRGSKNGQLLEN---------------PRF-GKMPLE-------LARKPISQSQ 904

  Fly  1024 SRDMKFTAENGSAHQ-----FPSS----------GIISLPPTPFQERAQ---------------- 1057
            ..:..|...|..:.|     |||.          |..|..|:....||.
Mouse   905 ISEFSFLGSNWDSFQGMMTSFPSGETTPRRLLAYGCCSKRPSNKHIRAAGPCLGGQWAQREGMKS 969

  Fly  1058 ----------------------FT-------------ISCP----------DGLAHGLSEQNIRL 1077
                                  |:             :|||          |||.........||
Mouse   970 PVCSSHSNGHCTGPGGKNNRMWFSSHPKQVSSTKPSLLSCPSPVPPLYLDDDGLPFPTDVIQHRL 1034

  Fly  1078 HQIVQEHKLREEMLLREIHGMRLALLEKGCPSCNSIVSTNMEHE---------NGSDIVENASTC 1133
            .||...::...|.|.|::..:::.|..:.|  |.......|::|         :|||..:..|..
Mouse  1035 RQIEAGYRQEVEQLRRQVRELQMRLDIRHC--CAPPAEPPMDYEDDFTCLKESDGSDTEDFGSDH 1097

  Fly  1134 SWEAVEERSGPASYAPSSIQEKKASSVLWVPDHAVSRCSSCQTEFWLGRRKHHCRSCGEIFCADC 1198
            |.:.:.|    ||:.|  :.:|:.....|||||..|.|.:|..||||.:|:||||:||.:|||.|
Mouse  1098 SEDCLSE----ASWEP--VDKKETEVTRWVPDHMASHCFNCDCEFWLAKRRHHCRNCGNVFCAGC 1156

  Fly  1199 SEFWAPLPNEKLFNPVRLCGSCYTSV 1224
            .....|:|:::|::||.:|.|||..:
Mouse  1157 CHLKLPIPDQQLYDPVLVCNSCYEHI 1182

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3632	NP_001096996.1	PH-like	35..147	CDD:302622	48/112 (43%)
		Myotub-related	221..590	CDD:284109	202/373 (54%)
		FYVE_MTMR4	1162..1221	CDD:277272	30/58 (52%)
Mtmr4	XP_006532446.1	PH-GRAM_MTMR4	37..150	CDD:270150	48/115 (42%)
		PTP-MTMR4	186..493	CDD:350435	174/321 (54%)
		Atrophin-1	743..>863	CDD:367360	31/153 (20%)
		FYVE_MTMR4	1120..1179	CDD:277272	30/58 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846016
Domainoid	1	1.000	451	1.000	Domainoid score	I509
eggNOG	1	0.900	-	-		E1_KOG4471
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	674	1.000	Inparanoid score	I727
Isobase	1	0.950	-	0	Normalized mean entropy	S3513
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D191120at33208
OrthoFinder	1	1.000	-	-		FOG0004824
OrthoInspector	1	1.000	-	-		otm42495
orthoMCL	1	0.900	-	-		OOG6_105196
Panther	1	1.100	-	-	O	PTHR10807
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2890
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.710