DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3632 and mtmr11

DIOPT Version :9

Sequence 1:	NP_001096996.1	Gene:	CG3632 / 32589	FlyBaseID:	FBgn0030735	Length:	1250	Species:	Drosophila melanogaster
Sequence 2:	NP_001313370.1	Gene:	mtmr11 / 101882209	ZFINID:	ZDB-GENE-130530-726	Length:	814	Species:	Danio rerio

Alignment Length:	823	Identity:	175/823 - (21%)
Similarity:	274/823 - (33%)	Gaps:	292/823 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   193 SNPLPDPASETISAAMSNRLQRSVRYESDFKNEVARLGFDLKGSWRISTANADFKLCPSYPPKLL 257
            ||...||:        .|.|:.|:.:|    .|:.|.|   ...||:|:.|..|::..|.|...:
Zfish   193 SNRRRDPS--------MNWLECSLGWE----QELERTG---ASGWRVSSVNDRFEMSTSLPRFNV 242

  Fly   258 VPCCITD-EMLHNVANFRGSRRLPAVVWRHQKSGAILARCSQPEVGWLGWRNTRDEQLLKALADA 321
            ||..:.| |:....|:| ...|:|...|||.:...:|...|        ::|
Zfish   243 VPQRVLDTELKKTFAHF-NEGRIPRWCWRHPRGSDLLRMAS--------FQN------------- 285

  Fly   322 CAFDRGEHARHSTCANAKAQPTKGSKETNGQSGLSGKSSPSLDDSSHEELTLDEIKKILIVDARS 386
                                                       :..||:   |:|:.:.:|
Zfish   286 -------------------------------------------NIYHEK---DDIRNLELV---- 300

  Fly   387 YTSAVTNRARGGGCECI-----EYYPC-AEIEFMNLGNIHAIRKSFHAVRQLC-------ASSPD 438
                    ..||...|:     |..|. |:|:..:.           .:|.||       .|.||
Zfish   301 --------LFGGQQLCVIVDLGEEMPSPADIQLAHT-----------RLRTLCLGDISSSVSVPD 346

  Fly   439 DPNWYGQLEKTMWMQHLSGLLGATMTVVHTIEKNGRPVLVHCSDGWDRTPQIVATAQLCLDPYYR 503
            | .|...||.|.|:.:....|.....|...:......|::...:..|....:.:..|:..||:.|
Zfish   347 D-KWLSTLESTRWLDYTRCCLRKAAEVCCLLRAGHMTVVLQEPEDRDMNCVVCSLVQVMCDPHCR 410

  Fly   504 TVEGFRVLVEREWLNFGHKFADRSGNGPNSDEVNERCPVFLQWLDLVHQIHRQYPCSFEFSISYL 568
            ||.||:.||::||:..||||..|......||:  |..||||.:||.|.|:..|||..|:.:..||
Zfish   411 TVAGFQGLVQKEWITAGHKFLSRINYHRESDK--EEAPVFLLFLDCVWQLWAQYPARFQLTEDYL 473

  Fly   569 IKLAQHSLSCLFGTFLCNSLRERIE------------NSVFDRTFS------------VWPFLAE 609
            :.|.......||.:||.||.|||..            |.:.|...|            ||.:..:
Zfish   474 LALHDSVHLPLFSSFLANSQRERCRRSQHLPQSYTPVNGLRDVPMSVPEEPVDPPFPPVWDWALQ 538

  Fly   610 TMYRNPLYKHETEKVLWPAHSVRFLYFWSDVYLGSLGNKNGTDLPLLSNERQSGHN-GLMAKTRS 673
              |.:......|:.:..|......|.          ||.|       :|..:|.|| ||..
Zfish   539 --YSSQRRARFTQPISQPTCPPPVLN----------GNLN-------TNLERSWHNDGLPG---- 580

  Fly   674 SEDLTTNELGQSTISRRSSDPNLTVESIVTDCFNANSNSMFDIRSEANNSVSENVQE------SV 732
                :...|.:||.|..|:         :....::||.|.:.....|.:|.|.:..|      |:
Zfish   581 ----SVFLLSRSTFSHPSN---------LLPWRSSNSGSYWKSHRRAPSSESLSGLERLIRACSL 632

  Fly   733 KDSKEVELDVTDATE------VGPCGR-----------------------SNNPIPDFHNDQ--- 765
            .:..|....:.|..|      :|||.|                       :.:|:     ||
Zfish   633 SEPSENNTILHDPYEPLLPLLLGPCVRVWRSCYLRGALHAQAFSHPVSSCTQHPV-----DQLAW 692

  Fly   766 ----------STASKRDILEVESQTQRRSSLESSQLIPGSVFIFGSSENDKNAVPSESEESLATS 820
                      ..:::|...:::.|..||.....:|......|:|.||.      .|:.::..|.|
Zfish   693 EVQQLREKLAQASNRRPENQIKHQEARRPESNLNQNANNGTFLFSSSR------VSQQQQQQAPS 751

  Fly   821 QKLNSESGRPFFIFGSSENDQSPVPLKSEDTSDISRALWHGAIETSTDTLIPAEPVQKPNSDNSS 885
            .:            |::::...|.|.:                 |::|   |..|.|:   ::..
Zfish   752 SR------------GAAQSSAPPRPQR-----------------TASD---PPRPAQR---NSGK 781

  Fly   886 RDHITSPTMELVSGDRKLESTSTVQASKISQSYNNLPKVHIRP 928
            ...:.....|..||.|.:.|.|.              |:|.||
Zfish   782 HTFLFGHQQEPQSGQRYIPSPSA--------------KLHKRP 810

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3632	NP_001096996.1	PH-like	35..147	CDD:302622
		Myotub-related	221..590	CDD:284109	93/382 (24%)
		FYVE_MTMR4	1162..1221	CDD:277272
mtmr11	NP_001313370.1	PH-GRAM_MTMR11	41..162	CDD:275433
		PTPc	210..495	CDD:304379	94/385 (24%)
		3-PAP	578..703	CDD:289355	24/146 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590737
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840