DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3632 and mtmr7

DIOPT Version :9

Sequence 1:	NP_001096996.1	Gene:	CG3632 / 32589	FlyBaseID:	FBgn0030735	Length:	1250	Species:	Drosophila melanogaster
Sequence 2:	XP_004911249.1	Gene:	mtmr7 / 100485851	XenbaseID:	XB-GENE-1008662	Length:	657	Species:	Xenopus tropicalis

Alignment Length:	761	Identity:	196/761 - (25%)
Similarity:	316/761 - (41%)	Gaps:	170/761 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 ESIKYLGRTDD-----GILALS-NYRIFLSKQS-TGYETYVPLGLIESVQVRDL----FQLIVNC 103
            |:::.|.|...     |.|.|: .:.||:...| |..||::....|.|::.:..    ..::::|
Frog    10 ENVRLLDRISSRKAALGTLYLTGTHIIFVENISETRKETWILYSQISSIEKQATATSGCPILIHC 74

  Fly   104 KDASTVRCSFPSAEQCSDWQRRIHL---MIGVPESLETLFAFPFYSWTCDVLGSGNGSGIVSAQA 165
            |:...::...|....|.|    |:|   .:..|...|.|:.|.|
Frog    75 KNFQVIQLIIPQERDCHD----IYLSLVRLSRPVKYEELYCFSF--------------------- 114

  Fly   166 NGNGLIAKDRCLTLHNGLAKPTANVTASNPLPDPASETISAAMSNRLQRSVRYES-----DFKNE 225
                               ||..:.|                         .:|.     |...|
Frog   115 -------------------KPNLDKT-------------------------EHEEGWKLVDLNEE 135

  Fly   226 VARLGFDLKGSWRISTANADFKLCPSYPPKLLVPCCITDEMLHNVANFRGSRRLPAVVWRHQKSG 290
            ..|:|.. |..|::|..|.|:::|.|||.:|.||...|..::...:.||...|.|.:.:..|.:.
Frog   136 YNRMGLP-KSLWQMSDVNRDYRVCDSYPTELYVPKSATVPIIVGSSKFRSRGRFPTLSYYCQDNN 199

  Fly   291 AILARCSQPEVGWLGWRNTRDEQLLKALADACAFDRGEHARHSTCANAKAQPTKGSKETNGQSGL 355
            |.:.|.|||..|:.. |...|||:|:|:.
Frog   200 ASICRSSQPLSGFSA-RCLEDEQMLQAIR------------------------------------ 227

  Fly   356 SGKSSPSLDDSSHEELTLDEIKKILIVDARSYTSAVTNRARGGGCECIEYYPCAEIEFMNLGNIH 420
              |::|..|             .:.:||.|...:|:.|||.|.|.|..:.|...:.:|:.:.|||
Frog   228 --KANPGSD-------------FLYVVDTRPKLNAMANRAAGKGYENEDNYSDIKFQFIGIENIH 277

  Fly   421 AIRKSFHAVRQLC-ASSPDDPNWYGQLEKTMWMQHLSGLLGATMTVVHTIEKNGRPVLVHCSDGW 484
            .:|.|...:.::| ..||...::...||.:.|::|:..::.|.:.:...:.:.|..|||||||||
Frog   278 VMRNSLQKMLEVCELRSPSMGDFLWGLESSGWLKHIKAIIDAGIFIAKAVSEEGASVLVHCSDGW 342

  Fly   485 DRTPQIVATAQLCLDPYYRTVEGFRVLVEREWLNFGHKFADRSGNGPNSDEVNERCPVFLQWLDL 549
            |||.|:.:.|.|.:||||||::||.||:|::|::|||||..|.||  ...:..|..||..|:::.
Frog   343 DRTAQVCSIASLLIDPYYRTIKGFMVLIEKDWISFGHKFNHRYGN--LDGDPKEVSPVIDQFIEC 405

  Fly   550 VHQIHRQYPCSFEFSISYLIKLAQHSLSCLFGTFLCNSLRERIENSVFDRTFSVWPFLAETM--Y 612
            |.|:..|:||:|||:..:|:.:..|..||.:|.||||..:||.|..|.:||:|:|.:|.:..  |
Frog   406 VWQLMEQFPCAFEFNERFLVHIHHHVYSCQYGNFLCNCQKERREIRVQERTYSLWSYLWKQRLDY 470

  Fly   613 RNPLYK---HETEKVLWPAHSVRFLYFWSDVY----LGSLGNKNGTD-LPLLSNERQSGHNGLMA 669
            .||||:   .:|:..|.|..|.....||..:|    .|....::.|| |..:..|.|.....|..
Frog   471 MNPLYRADHSQTQGTLRPNTSPSNFKFWRGLYNRFEKGMQPRQSVTDFLQAVKEETQQLEEELEF 535

  Fly   670 KTRSSEDLTTNEL-GQSTISRRSSDPNLTVESIVTDCFNANSNSMFDIRSEANNSVSEN------ 727
            ..:..:...:..| |..:.:.......|.:.:......|:..:....::|..:.|.|:.
Frog   536 MQKRWQKFESQHLNGTKSFNEIHESDKLQICATAYTSANSPQDYSSTLKSFPSRSPSQGEEDSAL 600

  Fly   728 --VQESVKDS-------KEVELDVTDATEVGPCGRSNNPIPDFHND 764
              .||.:|.|       .:.|..|.|.:...|.|..:.|..|...|
Frog   601 ILTQEHLKSSDPDLSANSDQESGVEDLSCRSPSGGDSLPSEDSGKD 646

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3632	NP_001096996.1	PH-like	35..147	CDD:302622	26/110 (24%)
		Myotub-related	221..590	CDD:284109	119/369 (32%)
		FYVE_MTMR4	1162..1221	CDD:277272
mtmr7	XP_004911249.1	PH-GRAM_MTMR7	1..103	CDD:270152	21/96 (22%)
mtmr7	XP_004911249.1	PTP-MTMR7	132..433	CDD:350431	111/355 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D824298at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010