DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3632 and LOC100333801

DIOPT Version :9

Sequence 1:	NP_001096996.1	Gene:	CG3632 / 32589	FlyBaseID:	FBgn0030735	Length:	1250	Species:	Drosophila melanogaster
Sequence 2:	XP_005171779.4	Gene:	LOC100333801 / 100333801	-ID:	-	Length:	955	Species:	Danio rerio

Alignment Length:	1247	Identity:	400/1247 - (32%)
Similarity:	579/1247 - (46%)	Gaps:	320/1247 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 RAAESYPKSQMEKEDSQLFVPFQELAGESIKYLGRTDDGILALSNYRIFLSKQSTGYETYVPLGL 87
            ::.|::..|.::.|.    |||..|.||.:.::.:|.:.:|||::||:.:..|.....  |||.|
Zfish     7 QSLEAHGSSGLQVEQ----VPFALLLGECVDHVEKTQECVLALTSYRLHIKLQENSIS--VPLQL 65

  Fly    88 IESVQVRDLFQLIVNCKDASTVRCSFPSAEQCSDWQRRIHLMIGVPESLETLFAFPFYSWTCDVL 152
            ||||:..:..|:.:.|||...:||:|.|.:||.||.|||....|.|..|:.||||.|.|  |
Zfish    66 IESVESHEPTQIQLTCKDCKVIRCNFLSVDQCQDWLRRISAASGPPARLQELFAFSFLS--C--- 125

  Fly   153 GSGNGSGIVSAQANGNGLIAKDRCLTLHNGLAKPTANVTASNPLPDPASETISAAMSNRLQRSVR 217
                          .|.:.|:||  .:|:|:.                             |:..
Zfish   126 --------------SNSVTAEDR--EVHDGIC-----------------------------RAGG 145

  Fly   218 YESDFKNEVARLGFDLKGSWRISTANADFKLCPSYPPKLLVPCCITDEMLHNVANFRGSRRLPAV 282
            ::..||.|:.|:|||...:||||..|:::::|.|||.::|||..:||:.|.|||.||..:|:|||
Zfish   146 HKQRFKRELQRMGFDTHSAWRISNINSNYRVCSSYPEQILVPAAVTDQQLENVAAFRSWKRIPAV 210

  Fly   283 VWRHQKSGAILARCSQPEVGWLGWRNTRDEQLLKALADACAFDRGEHARHSTCANAKAQPTKGSK 347
            |:|||.|||::.||.||||.|.||||..||.|::|:|.|||.|   .|.::..||       ||.
Zfish   211 VYRHQSSGAVIGRCGQPEVSWWGWRNADDEHLVQAIAKACATD---PAANTALAN-------GSC 265

  Fly   348 ETNGQSGLSGKSSPSLDDSSHE-ELTLDEIKKILIVDARSYTSAVTNRARGGGCECIEYYPCAEI 411
            ..|..:|....|.|.:.:...| |.:....:|:||:|||||.:||.|||:||||||.||||..|:
Zfish   266 VHNHANGTISGSDPHMANGKVEAEPSATPSQKLLIMDARSYAAAVANRAKGGGCECPEYYPNCEV 330

  Fly   412 EFMNLGNIHAIRKSFHAVRQLCASSPDDPNWYGQLEKTMWMQHLSGLLGATMTVVHTIEKNGRPV 476
            .||.:.|||:|||||..:|.|||..||..||...||.|.|:||||.||.|::.||:.::::.|||
Zfish   331 MFMGMANIHSIRKSFQCLRTLCAQVPDPLNWLSALEGTKWLQHLSLLLKASVLVVNAVDRDHRPV 395

  Fly   477 LVHCSDGWDRTPQIVATAQLCLDPYYRTVEGFRVLVEREWLNFGHKFADRSGNGPNSDEVNERCP 541
            ||||||||||||||:|.::|.|||:|||:|||.||||.|||:|||||::|.|:|..:|:||||||
Zfish   396 LVHCSDGWDRTPQILALSKLMLDPFYRTIEGFEVLVETEWLDFGHKFSERCGHGERADDVNERCP 460

  Fly   542 VFLQWLDLVHQIHRQYPCSFEFSISYLIKLAQHSLSCLFGTFLCNSLRERIENSVFDRTFSVWPF 606
            |||||||.|||:.||:||||:|:.::|:||.||:.|||||||||||::||.|..|.::|.|||..
Zfish   461 VFLQWLDCVHQLQRQFPCSFQFNEAFLVKLVQHTYSCLFGTFLCNSVKEREEQRVQEKTCSVWSL 525

  Fly   607 L--AETMYRNPLYKHETEKVLWPAHSVRFLYFWSDVYLGSLGNKNGTDLPLLSNERQSGHN---- 665
            |  |...:.|.||...:|.||.|...||.|..||.|||.:......:|...:.....|...
Zfish   526 LRPANQSFHNILYSPRSETVLRPVCHVRNLMLWSAVYLHNSAPSTPSDESCVPQSTPSASPIDTP 590

  Fly   666 -GLMAKTRSSEDLTTNELGQSTISRRSSDPNLTVESIVTDCFNANSNSMFDIRSEANNSVSENVQ 729
             ..:.||||.|:|:|: ....|.:||||||::..:.         .:.:..::....|:.:..:|
Zfish   591 VSRLPKTRSYENLSTS-CENLTPNRRSSDPSVKEKW---------QDHLLALKINGENTHTSPLQ 645

  Fly   730 ESV-------KDSKEVELDVTDATEVGPCGRSNNPIPDFHNDQSTASKRDILEVESQTQRRSSLE 787
            .::       ...|.:||.|||:              ...|.:.        ||..:..|:..|.
Zfish   646 HTLALNTTAAHTQKTLELSVTDS--------------QIENTEQ--------EVTEELNRKLELL 688

  Fly   788 SSQLIPGSVFIFGSSENDKNAVPSESEESLATSQKLNSESGRPFFIFGSSENDQSPVPLKSEDTS 852
            .|..:...     ||.|.||                               |||    :..||.|
Zfish   689 CSTSVSQD-----SSLNMKN-------------------------------NDQ----IFPEDIS 713

  Fly   853 DISRALWHGAIETSTDTLIPAEPVQKPNSDNSSRDHITSPTMELVSGDRKLESTSTVQASKISQS 917
            .|                           |.:|.|.:
Zfish   714 HI---------------------------DTTSADGL---------------------------- 723

  Fly   918 YNNLPKVHIRPNAVICPQRVDAFPHHLDLQVPRETTGNPDRCKPE-KLAKDANANANANGSLLAS 981
                                    ||       :.|.||.:...: .:..|:::|..|.
Zfish   724 ------------------------HH-------KITHNPSQSSSQSSMESDSSSNHTAQ------ 751

  Fly   982 DGYNGEESLFISPDLQRFVGQSPFDAPSTGGRIRRNTFGSSYSRDMKFTAENGSAHQFPSSGIIS 1046
                                ::||.:||                            |..::|.:|
Zfish   752 --------------------KNPFHSPS----------------------------QMSAAGDVS 768

  Fly  1047 LPPTPFQERAQFTISCPDGLAHGLSEQNIRLHQIVQEHKLREEMLLREIHGMRLALLEKGCPSCN 1111
            .|...::..|.|.....|||:.......:||.|:...|:|:.|.|.:::..:...:
Zfish   769 PPSGVWRCSAAFGPLERDGLSVHSDAVQVRLQQMETGHQLQVETLKKQVQELWSRI--------- 824

  Fly  1112 SIVSTNMEHENG--SDIVENASTCSWEAVEERSGPASYAPSS---IQEKKASSVLWVPDHAVSRC 1171
                    |.||  |.:.:..:....|.: :|||......||   ||:|......|..|.: |||
Zfish   825 --------HANGKLSSLPDGDNNTESECL-QRSGATDLTESSAEHIQQKDTEVSQWFSDQS-SRC 879

  Fly  1172 SSCQTEFWLGRRKHHCRSCGEIFCADCSEFWAPLPNEKLFNPVRLCGSCYTSVTTNVQEYAAVPA 1236
            ..|:..||...|:||||:||.:||..|.:  ..:.:::|.....:|..|.:.:..:....|..||
Zfish   880 YGCERRFWQAARRHHCRNCGNVFCTSCCD--QKVASQQLREHKHMCQVCLSHLRPSPVPPALPPA 942

  Fly  1237 ESQAKDDETSSA 1248
            :.:.:...|:|:
Zfish   943 DLELEKPITASS 954

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3632	NP_001096996.1	PH-like	35..147	CDD:302622	45/111 (41%)
		Myotub-related	221..590	CDD:284109	207/369 (56%)
		FYVE_MTMR4	1162..1221	CDD:277272	20/58 (34%)
LOC100333801	XP_005171779.4	PH-like	21..122	CDD:327399	43/106 (41%)
		Myotub-related	149..511	CDD:310891	208/371 (56%)
		FYVE_like_SF	871..926	CDD:333710	20/57 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D191120at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010