DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment f2 and flz

DIOPT Version :9

Sequence 1:	XP_005169022.1	Gene:	f2 / 325881	ZFINID:	ZDB-GENE-030131-4606	Length:	635	Species:	Danio rerio
Sequence 2:	NP_001137622.1	Gene:	flz / 35902	FlyBaseID:	FBgn0286782	Length:	1693	Species:	Drosophila melanogaster

Alignment Length:	483	Identity:	116/483 - (24%)
Similarity:	180/483 - (37%)	Gaps:	150/483 - (31%)

- Green bases have known domain annotations that are detailed below.

Zfish   178 PDKHKDGPWCFTRDPTVRRETCNVPKCGEAVVPPPKAPTAKPEQRHV--------ISKCLPGNGE 234
            |:|........||.|..||.|     ....|....:.|..|...|.|        :|...|.:.|
  Fly  1322 PNKKTSAVSTTTRKPATRRTT-----VAAKVTTTTRRPATKKPTRRVSSTVKTTTVSSARPADDE 1381

Zfish   235 TYTGELFVTLGLHTCLQWSSAEVQALIKKKELLPQVQLVKNHCRNPDGDMEGPWCYIKAASGNIT 299
            ....|             ...:|                     ||:
  Fly  1382 IVDEE-------------DEEDV---------------------NPN------------------ 1394

Zfish   300 IDYCDLELCDAPLDKFVEEG---------GGRE-----RTTLDQRKAFFNPRSFGNGELDCGERP 350
                       |.|..:::|         .||:     ||......||.:|.:      :||.||
  Fly  1395 -----------PSDNEIDQGATLSSYGGANGRKIHSTSRTLPTPNLAFHSPST------ECGVRP 1442

Zfish   351 LFEKINKADKNEKELLMSYTGSRIVGGDEAEVASAPWQVMLYKRSPQELL----CGASLISDEWI 411
                             .....|||||..:...:.||||::.:.:...|.    ||..||:..::
  Fly  1443 -----------------HVKSGRIVGGKGSTFGAYPWQVLVRESTWLGLFTKNKCGGVLITSRYV 1490

Zfish   412 LTAAHCILYPPWNKNFTINDIIVRLGKHSRT---KYERGIEKIVAIDEIIVHPKYNWKENLNRDI 473
            :|||||      ...| :..::..:|:...:   :.:|.:.|  .:..:|||.:|: ......|:
  Fly  1491 ITAAHC------QPGF-LASLVAVMGEFDISGDLESKRSVTK--NVKRVIVHRQYD-PATFENDL 1545

Zfish   474 ALLHMKKPVVFTSEIHPVCLPTKSIAKNLMFAGYKGRVTGWGNLRESWTSNPTNLPTVLQQIHLP 538
            |||.:..||.|.:.|.|:|:| ..:|.   |.|....|||||.|:..     ..:|:|||::.:|
  Fly  1546 ALLELDSPVQFDTHIVPICMP-NDVAD---FTGRMATVTGWGRLKYG-----GGVPSVLQEVQVP 1601

Zfish   539 IVDQSICR------NSTSVIITDNMFCAGYQPDDSKRGDACEGDSGGPFVMKSPSDNRWYQIGIV 597
            |::.|:|:      .....|:| :..||||.   :.:.|:||||||||.|::.| |.|:...|.|
  Fly  1602 IIENSVCQEMFHTAGHNKKILT-SFLCAGYA---NGQKDSCEGDSGGPLVLQRP-DGRYELAGTV 1661

Zfish   598 SWGEGCDRDGKYGFYTHLFRMRRWMKKV 625
            |.|..|......|.|......:.|::.:
  Fly  1662 SHGIKCAAPYLPGVYMRTTFYKPWLRSI 1689

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
f2	XP_005169022.1	GLA	39..100	CDD:214503
		KR	126..206	CDD:214527	8/27 (30%)
		KR	228..309	CDD:214527	6/80 (8%)
		Thrombin_light	326..373	CDD:286482	7/46 (15%)
		Tryp_SPc	373..621	CDD:214473	81/260 (31%)
		Tryp_SPc	374..625	CDD:238113	81/263 (31%)
flz	NP_001137622.1	PRK14948	<272..452	CDD:237862
		PRK11633	<365..>439	CDD:236940
		PRK10263	<547..>1005	CDD:236669
		PHA03247	<792..1096	CDD:223021
		Tryp_SPc	1449..1689	CDD:238113	81/263 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910