DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9911 and TMX4

DIOPT Version :9

Sequence 1:	NP_573111.1	Gene:	CG9911 / 32588	FlyBaseID:	FBgn0030734	Length:	412	Species:	Drosophila melanogaster
Sequence 2:	NP_066979.2	Gene:	TMX4 / 56255	HGNCID:	25237	Length:	349	Species:	Homo sapiens

Alignment Length:	160	Identity:	45/160 - (28%)
Similarity:	67/160 - (41%)	Gaps:	27/160 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 GKLGP-CVALVA--ILQLLQYTQPADAA------GAVPMTSDNIDMTLASNELVFLNFYAEWCRF 64
            |:.|| ..||:|  |..:.....|.:||      ...|||:.|  .||.......|.|||.||.
Human     4 GRCGPQLTALLAAWIAAVAATAGPEEAALPPEQSRVQPMTASN--WTLVMEGEWMLKFYAPWCP- 65

  Fly    65 SNILAPIFAEAADKIKEEFPEAGKVV---LGKVDCDKETAIASRFHINKYPTLKIVRNGQLSKRE 126
                   ..:..|...|.|.:.|:::   :||||..:|..::.||.:...|.....::|..  |.
Human    66 -------SCQQTDSEWEAFAKNGEILQISVGKVDVIQEPGLSGRFFVTTLPAFFHAKDGIF--RR 121

  Fly   127 YRGQRSAEAFLEFV---KKQLEDPIQEFKS 153
            |||....|....::   |.|..:|:..:||
Human   122 YRGPGIFEDLQNYILEKKWQSVEPLTGWKS 151

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9911	NP_573111.1	PDI_a_ERp44	33..140	CDD:239294	31/115 (27%)
		PDI_b_ERp44	148..241	CDD:239368	2/6 (33%)
		Thioredoxin_6	171..357	CDD:290560
		PDI_b'_ERp44	252..362	CDD:239370
TMX4	NP_066979.2	PDI_a_TMX	37..137	CDD:239292	30/111 (27%)
TMX4	NP_066979.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	225..349
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910