DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9911 and DNAJC10

DIOPT Version :9

Sequence 1:	NP_573111.1	Gene:	CG9911 / 32588	FlyBaseID:	FBgn0030734	Length:	412	Species:	Drosophila melanogaster
Sequence 2:	NP_061854.1	Gene:	DNAJC10 / 54431	HGNCID:	24637	Length:	793	Species:	Homo sapiens

Alignment Length:	393	Identity:	85/393 - (21%)
Similarity:	141/393 - (35%)	Gaps:	119/393 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 DMTLASNELVFLNFYAEWCRFSNILAPIFAEAADKIKEEFPEAGKVVLGKVDCDKETAIASRFHI 108
            |..:.|.||.|:|||:..|...:.|||.:.:.|.::.      |.:.:|.|:|..:..:.....:
Human   140 DAAVNSGELWFVNFYSPGCSHCHDLAPTWRDFAKEVD------GLLRIGAVNCGDDRMLCRMKGV 198

  Fly   109 NKYPTLKIVRNGQLSKREYRGQRSAEAFLEFVKKQLEDPIQEF------KSL------------- 154
            |.||:|.|.|:| ::..:|.|.||.|:.:.|..:.:...:.|.      .|:
Human   199 NSYPSLFIFRSG-MAPVKYHGDRSKESLVSFAMQHVRSTVTELWTGNFVNSIQTAFAAGIGWLIT 262

  Fly   155 ---KDLENLDSKKRLIL----------GYFDRRDQPEYDIFRKVATNLKEDCQFHVGFGDAAQAM 206
               |..:.|.|:.||.|          |:.|...|          .||   |: .:....:..|.
Human   263 FCSKGGDCLTSQTRLRLSGMLDGLVNVGWMDCATQ----------DNL---CK-SLDITTSTTAY 313

  Fly   207 HPPGTPI-------IVFRPDVALSHENDETYTGSLQNFDELKIWVQEKCVPLVREITFENAEELT 264
            .|||..:       |:|    ..|.:..|.|...:.|..:.:         |:...|.|  :.|.
Human   314 FPPGATLNNKEKNSILF----LNSLDAKEIYLEVIHNLPDFE---------LLSANTLE--DRLA 363

  Fly   265 EEGLPFLILFHHPTDHNS----IKDYKSIIERQLLDEKQNVNFLTADGKRFAHPLHHLGKSEDDL 325
            ..  .:|:.||...:.||    :|..|::::..                       |:.....|.
Human   364 HH--RWLLFFHFGKNENSNDPELKKLKTLLKND-----------------------HIQVGRFDC 403

  Fly   326 PLIAIDSFKHMYLF-PHFSDMYSPGKL-------KQFLQDLYS-GKLHREFH---YGPD--PSND 376
            . .|.|...::|:| |..:.....|..       |:.|.|:.: .|.....|   .||.  |:||
Human   404 S-SAPDICSNLYVFQPSLAVFKGQGTKEYEIHHGKKILYDILAFAKESVNSHVTTLGPQNFPAND 467

  Fly   377 IEP 379
            .||
Human   468 KEP 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9911	NP_573111.1	PDI_a_ERp44	33..140	CDD:239294	29/95 (31%)
		PDI_b_ERp44	148..241	CDD:239368	24/131 (18%)
		Thioredoxin_6	171..357	CDD:290560	36/204 (18%)
		PDI_b'_ERp44	252..362	CDD:239370	21/122 (17%)
DNAJC10	NP_061854.1	DnaJ	34..>132	CDD:223560
		PDI_a_ERdj5_N	129..229	CDD:239301	29/95 (31%)
		Trxb 1	235..350		24/132 (18%)
		Trxb 2	348..463		26/151 (17%)
		PDI_a_ERdj5_C	453..550	CDD:239302	8/18 (44%)
		PDI_a_ERdj5_C	556..663	CDD:239302
		PDI_a_ERdj5_C	670..775	CDD:239302
		Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	790..793
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910