DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9911 and CG10029

DIOPT Version :9

Sequence 1:	NP_573111.1	Gene:	CG9911 / 32588	FlyBaseID:	FBgn0030734	Length:	412	Species:	Drosophila melanogaster
Sequence 2:	NP_649716.1	Gene:	CG10029 / 40883	FlyBaseID:	FBgn0037498	Length:	410	Species:	Drosophila melanogaster

Alignment Length:	418	Identity:	205/418 - (49%)
Similarity:	287/418 - (68%)	Gaps:	24/418 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 IGKLGPCVALVAILQLLQYTQPADAAGAVPMTSDNIDMTLASNELVFLNFYAEWCRFSNILAPIF 72
            :|.|....:|..::.|  ::..|..:..|.:|.:|:...:.|||||.|:||.:|||||.||.|||
  Fly     4 VGSLHILYSLAILVSL--HSLVAGNSSVVAVTHENLQGIIDSNELVLLSFYTDWCRFSQILQPIF 66

  Fly    73 AEAADKIKEEFPEAGKVVLGKVDCDKETAIASRFHINKYPTLKIVRNGQLSKREYRGQRSAEAFL 137
            .|||.|:.::|||.|:|:||||:||.|..:|.:|.|.||||:||||||.:..:|||||||.||..
  Fly    67 EEAAAKVIQKFPENGRVILGKVNCDTEDILADQFDILKYPTIKIVRNGLIGNQEYRGQRSVEALF 131

  Fly   138 EFVKKQLEDPIQEFKSLKDLENLDSKKRLILGYFDRRDQPEYDIFRKVATNLKEDCQFHVGFGDA 202
            :||:|:|.|||:||.::.||:|:|....:::|||..:|..|||.:|:||:.|:.||:|.|||||.
  Fly   132 QFVEKELSDPIKEFHNIDDLKNVDVGYGIVIGYFISKDHAEYDNYRRVASLLRNDCRFLVGFGDL 196

  Fly   203 AQAMHPPGTPIIVFRPDVAL-SHEND-ETYTGSLQNFDELKIWVQEKCVPLVREITFENAEELTE 265
            .:.:.|||...::||.|.:: :|:|. ..|.|::.:|.||..|:.:.|||||||:||:|||||:|
  Fly   197 TKDLRPPGKNALIFRGDPSIPNHKNQYSEYLGNMTSFKELTFWIDKTCVPLVREVTFDNAEELSE 261

  Fly   266 EGLPFLILFHHPTDHNSIKDYKSIIERQLLDEKQNVNFLTADGKRFAHPLHHLGKSEDDLPLIAI 330
            |||||::||::..|.:.|:::|:.|:.|:.:|.: |.||||:|:.|.|||.|||||..|||:|||
  Fly   262 EGLPFVLLFYNKDDLSPIQEFKNAIQSQMENETR-VIFLTAEGEVFKHPLFHLGKSPSDLPVIAI 325

  Fly   331 DSFKHMYLFPHFSDMYSPGKLKQFLQDLYSGKLHREFHYGPDPSNDIEP--DP-------HTGKG 386
            |||.||||||.|.|:|.||.||:|:.||:||.||..:|.......|:|.  ||       |
  Fly   326 DSFMHMYLFPRFQDIYDPGALKKFIDDLFSGALHYNYHVAQQAKEDLESIIDPTEDLPVVH---- 386

  Fly   387 TSPPESKFKELGPSKHRYTLLE--KDEL 412
                |||||:|.||||||||:.  :|||
  Fly   387 ----ESKFKDLKPSKHRYTLVNRTRDEL 410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9911	NP_573111.1	PDI_a_ERp44	33..140	CDD:239294	59/106 (56%)
		PDI_b_ERp44	148..241	CDD:239368	38/94 (40%)
		Thioredoxin_6	171..357	CDD:290560	97/187 (52%)
		PDI_b'_ERp44	252..362	CDD:239370	65/109 (60%)
CG10029	NP_649716.1	PDI_a_ERp44	27..134	CDD:239294	59/106 (56%)
		PDI_b_ERp44	142..237	CDD:239368	38/94 (40%)
		Thioredoxin_6	165..352	CDD:290560	97/187 (52%)
		PDI_b'_ERp44	248..357	CDD:239370	65/109 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45457270
Domainoid	1	1.000	72	1.000	Domainoid score	I3299
eggNOG	1	0.900	-	-		E2759_KOG0912
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	366	1.000	Inparanoid score	I1251
Isobase	1	0.950	-	0.930827	Normalized mean entropy	S1743
OMA	1	1.010	-	-		QHG52519
OrthoDB	1	1.010	-	-		D318483at33208
OrthoFinder	1	1.000	-	-		FOG0006584
OrthoInspector	1	1.000	-	-		otm25284
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR46295
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4826
	12	11.860