DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9911 and pdia7

DIOPT Version :9

Sequence 1:	NP_573111.1	Gene:	CG9911 / 32588	FlyBaseID:	FBgn0030734	Length:	412	Species:	Drosophila melanogaster
Sequence 2:	NP_998070.1	Gene:	pdia7 / 405841	ZFINID:	ZDB-GENE-040426-2238	Length:	488	Species:	Danio rerio

Alignment Length:	435	Identity:	114/435 - (26%)
Similarity:	185/435 - (42%)	Gaps:	76/435 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 PCVALVAILQLLQYTQPADAAGAVPMTSDNIDMTLASNELVFLNFYAEWCRFSNILAPIFAEAAD 77
            ||..:.|:|.:..    |:.:..:.:...:.|.:...::.:.:.|:|.||.....|||.:..||.
Zfish     4 PCFIICAVLTVWL----AEGSDVLELGDSDFDRSAGMHDTLLVEFFAPWCGHCQRLAPEYEAAAT 64

  Fly    78 KIKEEFPEAGKVVLGKVDCDKETAIASRFHINKYPTLKIVRNGQLSKREYRGQRSAEAFLEFVKK 142
            |:|      |.:.|.||||...:....||.:|.||||||.|||:.| ..|.|.|:|:..:.::||
Zfish    65 KLK------GTLALAKVDCTVNSETCERFGVNGYPTLKIFRNGEES-GAYDGPRTADGIVSYMKK 122

  Fly   143 QLEDPIQEFKSLKDLEN-LDSKKRLILGYFDRRDQPEYDIFRKVATNLKEDCQF-HVGFGDAAQA 205
            |............||:. :|:.:..::|:|...|..:...|.|.::.|::..:| |.....|...
Zfish   123 QAGPSSVALLKEADLDGFVDNYEASVVGFFSGEDSAQLAEFLKASSALRDSYRFAHSTDVGAGLK 187

  Fly   206 MHPPGTPIIVFRPDVALS--HENDETYTGSLQNFDELKIWVQEKCVPLVREITFENAEELTEEGL 268
            ....|..:::|||....|  .:|...||..| :...|..:|::..:.|...:|.||.:.:.|..|
Zfish   188 YGVDGECVLLFRPPRLSSKFEDNVVKYTEHL-SVSSLHKFVKDNILGLCPHMTMENRDTVRESDL 251

  Fly   269 PFLILF------HHPTDHNSIKDYKSIIERQLLDEKQNVNFLTADGKRFAHPLHH---LGKSE-D 323
              |..|      .:|...|..::....:..|..|  :.:.|..||.:.|...|..   :..|| .
Zfish   252 --LTAFFNVDYLRNPKGTNYWRNRIMKVATQFQD--RGLTFAVADRQEFQDELEEEFGVSSSEGG 312

  Fly   324 DLPLIAIDSFKHMYLFPHFSDMYS-------PGK-LKQFLQDLYSGKLHR--------EFHYGP- 371
            |:||:.|.:        .....||       .|| |::||:|.::.:|.|        |.:.||
Zfish   313 DVPLVTIRT--------RAGQKYSMQEEFTRDGKSLEKFLEDYFAKRLKRYVKSEPIPESNDGPV 369

  Fly   372 -------------DPSNDIEPD---PHTG--KGTSPPESKFKELG 398
                         ||..|:..:   |..|  |...|   |:||||
Zfish   370 KVLVADTFDAIVNDPEKDVLVEFYAPWCGHCKNLEP---KYKELG 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9911	NP_573111.1	PDI_a_ERp44	33..140	CDD:239294	35/106 (33%)
		PDI_b_ERp44	148..241	CDD:239368	21/96 (22%)
		Thioredoxin_6	171..357	CDD:290560	49/206 (24%)
		PDI_b'_ERp44	252..362	CDD:239370	30/127 (24%)
pdia7	NP_998070.1	ER_PDI_fam	20..483	CDD:273457	109/415 (26%)
		Thioredoxin_like	25..124	CDD:294274	37/105 (35%)
		PDI_b_ERp57	127..231	CDD:239367	23/104 (22%)
		PDI_b'_ERp72_ERp57	235..348	CDD:239371	30/124 (24%)
		PDI_a_PDI_a'_C	368..471	CDD:239293	13/47 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910