DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9911 and erp44

DIOPT Version :9

Sequence 1:	NP_573111.1	Gene:	CG9911 / 32588	FlyBaseID:	FBgn0030734	Length:	412	Species:	Drosophila melanogaster
Sequence 2:	NP_957186.1	Gene:	erp44 / 393866	ZFINID:	ZDB-GENE-040426-1902	Length:	408	Species:	Danio rerio

Alignment Length:	380	Identity:	191/380 - (50%)
Similarity:	268/380 - (70%)	Gaps:	10/380 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 MTSDNIDMTLASNELVFLNFYAEWCRFSNILAPIFAEAADKIKEEFPEAGKVVLGKVDCDKETAI 102
            :.|.|||..|....:..:||||:|||||.:|.|||.||::.::||:|:|.:||.|:||||:.:.:
Zfish    34 LDSGNIDDILNGAGVALVNFYADWCRFSQMLHPIFEEASNIVREEYPDATQVVFGRVDCDQHSDL 98

  Fly   103 ASRFHINKYPTLKIVRNGQLSKREYRGQRSAEAFLEFVKKQLEDPIQEFKSLKDLENLDSKKRLI 167
            |.|:.|:||||||:.|||.:.|||||||||..|..:|:::|..|||:|.::|:::..:|..:|.|
Zfish    99 AQRYRISKYPTLKLFRNGMMMKREYRGQRSVTAIADFIRQQKVDPIKEIENLEEISTVDRSRRTI 163

  Fly   168 LGYFDRRDQPEYDIFRKVATNLKEDCQFHVGFGDAAQAMHPPGTPIIVFRPDVALSHEN--DETY 230
            :|||::||...|..:.|||..|::||.|...||:.::.....|..|| ::|    ..||  |..|
Zfish   164 IGYFEKRDSDNYRTYEKVANILRDDCAFLAAFGEVSKPERFSGDNII-YKP----LGENAPDMVY 223

  Fly   231 TGSLQNFDELKIWVQEKCVPLVREITFENAEELTEEGLPFLILFHHPTDHNSIKDYKSIIERQLL 295
            .|||.|||....|.|:|||||||||||||.|||||||:|||||||...|..|::.::..:.|||:
Zfish   224 MGSLTNFDLSYAWTQDKCVPLVREITFENGEELTEEGIPFLILFHQKDDTESLEKFQQEVARQLI 288

  Fly   296 DEKQNVNFLTADGKRFAHPLHHLGKSEDDLPLIAIDSFKHMYLFPHFSDMYSPGKLKQFLQDLYS 360
            .||.::|||.||..:|.|||.|:.|:..|.|:||||||:|||:||.|||:..||||:||:.||:|
Zfish   289 SEKGSINFLHADCDKFRHPLLHIQKTPADCPVIAIDSFRHMYVFPEFSDLAVPGKLRQFVLDLHS 353

  Fly   361 GKLHREFHYGPDPSNDI--EPDPHTGKGTSPPESKFKELGPSKHRYTLL-EKDEL 412
            ||||||||:||||::..  :.:.:....::||||.|::|.||:.|||:| ::|||
Zfish   354 GKLHREFHHGPDPTDSTPGQQEENREVPSNPPESSFQKLAPSETRYTILRDRDEL 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9911	NP_573111.1	PDI_a_ERp44	33..140	CDD:239294	53/101 (52%)
		PDI_b_ERp44	148..241	CDD:239368	35/94 (37%)
		Thioredoxin_6	171..357	CDD:290560	96/187 (51%)
		PDI_b'_ERp44	252..362	CDD:239370	65/109 (60%)
erp44	NP_957186.1	PDI_a_ERp44	29..136	CDD:239294	53/101 (52%)
		PDI_b_ERp44	144..234	CDD:239368	35/94 (37%)
		Thioredoxin_6	167..348	CDD:290560	95/185 (51%)
		PDI_b'_ERp44	245..355	CDD:239370	65/109 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170587098
Domainoid	1	1.000	188	1.000	Domainoid score	I3247
eggNOG	1	0.900	-	-		E2759_KOG0912
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12638
Inparanoid	1	1.050	389	1.000	Inparanoid score	I1948
OMA	1	1.010	-	-		QHG52519
OrthoDB	1	1.010	-	-		D318483at33208
OrthoFinder	1	1.000	-	-		FOG0006584
OrthoInspector	1	1.000	-	-		otm25284
orthoMCL	1	0.900	-	-		OOG6_107572
Panther	1	1.100	-	-	LDO	PTHR46295
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3277
SonicParanoid	1	1.000	-	-		X4826
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800