DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9911 and Erp44

DIOPT Version :9

Sequence 1:	NP_573111.1	Gene:	CG9911 / 32588	FlyBaseID:	FBgn0030734	Length:	412	Species:	Drosophila melanogaster
Sequence 2:	NP_001008318.1	Gene:	Erp44 / 298066	RGDID:	1309176	Length:	406	Species:	Rattus norvegicus

Alignment Length:	376	Identity:	192/376 - (51%)
Similarity:	266/376 - (70%)	Gaps:	4/376 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 MTSDNIDMTLASNELVFLNFYAEWCRFSNILAPIFAEAADKIKEEFPEAGKVVLGKVDCDKETAI 102
            :.|:|||..|.:.::..:||||:|||||.:|.|||.||:|.||||:|:..:||..:||||:.:.|
  Rat    34 LDSENIDEILNNADVALVNFYADWCRFSQMLHPIFEEASDVIKEEYPDKNQVVFARVDCDQHSDI 98

  Fly   103 ASRFHINKYPTLKIVRNGQLSKREYRGQRSAEAFLEFVKKQLEDPIQEFKSLKDLENLDSKKRLI 167
            |.|:.|:||||||:.|||.:.|||||||||.:|..:::::|..:|:.|.:||.::.|||..||.|
  Rat    99 AQRYRISKYPTLKLFRNGMMMKREYRGQRSVKALADYIRQQKSNPVHEIQSLDEVTNLDRSKRNI 163

  Fly   168 LGYFDRRDQPEYDIFRKVATNLKEDCQFHVGFGDAAQAMHPPGTPIIVFRPDVALSHENDETYTG 232
            :|||:::|...|.:|.:||:.|.:||.|...|||.::.....|..:|...|..::.   |..|.|
  Rat   164 IGYFEQKDSDNYRVFERVASILHDDCAFLSAFGDLSKPERYSGDNLIYKPPGRSVP---DMVYLG 225

  Fly   233 SLQNFDELKIWVQEKCVPLVREITFENAEELTEEGLPFLILFHHPTDHNSIKDYKSIIERQLLDE 297
            |:.|||....|:|:|||||||||||||.|||||||||||||||...|..|::.:::.:.|||:.|
  Rat   226 SMTNFDVTFNWIQDKCVPLVREITFENGEELTEEGLPFLILFHMKEDTESLEIFQNEVARQLISE 290

  Fly   298 KQNVNFLTADGKRFAHPLHHLGKSEDDLPLIAIDSFKHMYLFPHFSDMYSPGKLKQFLQDLYSGK 362
            |..:|||.||..:|.|||.|:.|:..|.|:||||||:|||:|..|.|:..|||||||:.||:|||
  Rat   291 KGTINFLHADCDKFRHPLLHIQKTPADCPVIAIDSFRHMYVFGDFKDVLIPGKLKQFVFDLHSGK 355

  Fly   363 LHREFHYGPDPSNDIEPDPHTGKGTSPPESKFKELGPSKHRYTLL-EKDEL 412
            ||||||:||||::....:......:|||||.|::|.||::||||| ::|||
  Rat   356 LHREFHHGPDPTDTAPGEQDQDVASSPPESSFQKLAPSEYRYTLLRDRDEL 406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9911	NP_573111.1	PDI_a_ERp44	33..140	CDD:239294	55/101 (54%)
		PDI_b_ERp44	148..241	CDD:239368	34/92 (37%)
		Thioredoxin_6	171..357	CDD:290560	92/185 (50%)
		PDI_b'_ERp44	252..362	CDD:239370	65/109 (60%)
Erp44	NP_001008318.1	PDI_a_ERp44	29..136	CDD:239294	55/101 (54%)
		PDI_b_ERp44	144..234	CDD:239368	34/92 (37%)
		Thioredoxin_6	167..350	CDD:290560	92/185 (50%)
		PDI_b'_ERp44	245..355	CDD:239370	65/109 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346137
Domainoid	1	1.000	185	1.000	Domainoid score	I3293
eggNOG	1	0.900	-	-		E2759_KOG0912
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12638
Inparanoid	1	1.050	398	1.000	Inparanoid score	I1885
OMA	1	1.010	-	-		QHG52519
OrthoDB	1	1.010	-	-		D318483at33208
OrthoFinder	1	1.000	-	-		FOG0006584
OrthoInspector	1	1.000	-	-		otm45840
orthoMCL	1	0.900	-	-		OOG6_107572
Panther	1	1.100	-	-	LDO	PTHR46295
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4826
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770