DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9911 and erp-44.1

DIOPT Version :9

Sequence 1:	NP_573111.1	Gene:	CG9911 / 32588	FlyBaseID:	FBgn0030734	Length:	412	Species:	Drosophila melanogaster
Sequence 2:	NP_001367560.1	Gene:	erp-44.1 / 172191	WormBaseID:	WBGene00016278	Length:	411	Species:	Caenorhabditis elegans

Alignment Length:	402	Identity:	193/402 - (48%)
Similarity:	259/402 - (64%)	Gaps:	23/402 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 LQLLQYTQPADAAGAVPMTSDNIDMTLASNELVFLNFYAEWCRFSNILAPIFAEAADKIKEEFPE 85
            |.||.:......|..|.:||.|.:.|:.:|||||:||||:|||||.:|.|||.||::|.|:..|
Worm    23 LSLLLFCPALLNAEVVSLTSQNFEQTIQANELVFVNFYADWCRFSQMLKPIFLEASEKFKDAAP- 86

  Fly    86 AGKVVLGKVDCDKETAIASRFHINKYPTLKIVRNGQLSKREYRGQRSAEAFLEFVKKQLEDPIQE 150
             ||::...||.||...||:::|:|||||||:.|||:.:|||||..||.||..||:.||:|..:::
Worm    87 -GKIMWASVDADKNNDIATKYHVNKYPTLKLFRNGEAAKREYRSSRSVEALSEFINKQMEVTVKK 150

  Fly   151 F---KSLKDLENLDSKKRLILGYFDRRDQPEYDIFRKVATNLKEDCQFHVGFGD------AAQAM 206
            |   .:|:...|  .:|...:|||...:..||.....||...:::|:|.||.||      |..|.
Worm   151 FIEKNALQAAHN--PEKNTFIGYFHDENSVEYKNLMNVAMFYRDECEFMVGIGDLNFPGEAPAAG 213

  Fly   207 HPPGTPIIVFRPDVALSHENDETYTGSLQNFDELKIWVQEKCVPLVREITFENAEELTEEGLPFL 271
            .||.   :||:|.....:.....::|....::.||.||.:|||||||||||:||||||||||||:
Worm   214 QPPK---LVFQPSNKAVNPAQIPFSGDFATYEYLKQWVADKCVPLVREITFQNAEELTEEGLPFM 275

  Fly   272 ILFHHPTDHNSIKDYKSIIERQLLDEKQNVNFLTADGKRFAHPLHHLGKSEDDLPLIAIDSFKHM 336
            |||....|..|.|.:...|.|:|.|:::.:|.|..||..|.|||.||||||.|||:||||||:||
Worm   276 ILFKKSDDKVSEKIFTDAIVRELPDQRKAINCLVGDGTIFKHPLSHLGKSESDLPVIAIDSFRHM 340

  Fly   337 YLFPHFSDMYSPGKLKQFLQDLYSGKLHREFHYGPDP-SNDIEPDPHTGKGTSPPESKFKELGPS 400
            |||.:|.|:..||||::|:.||:|||||||||:|||| :.:..||      |.||.|.|::|.|:
Worm   341 YLFKNFEDVNVPGKLREFVLDLHSGKLHREFHHGPDPVTGNQAPD------TEPPPSTFEKLKPA 399

  Fly   401 KHRYTLLEKDEL 412
            ..|||:|:|.||
Worm   400 SSRYTILDKTEL 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9911	NP_573111.1	PDI_a_ERp44	33..140	CDD:239294	58/106 (55%)
		PDI_b_ERp44	148..241	CDD:239368	25/101 (25%)
		Thioredoxin_6	171..357	CDD:290560	91/191 (48%)
		PDI_b'_ERp44	252..362	CDD:239370	66/109 (61%)
erp-44.1	NP_001367560.1	PDI_a_ERp44	35..140	CDD:239294	58/106 (55%)
		PDI_b_ERp44	148..245	CDD:239368	25/101 (25%)
		PDI_b'_ERp44	256..366	CDD:239370	66/109 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162556
Domainoid	1	1.000	130	1.000	Domainoid score	I3241
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12638
Inparanoid	1	1.050	366	1.000	Inparanoid score	I1251
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52519
OrthoDB	1	1.010	-	-		D318483at33208
OrthoFinder	1	1.000	-	-		FOG0006584
OrthoInspector	1	1.000	-	-		otm14341
orthoMCL	1	0.900	-	-		OOG6_107572
Panther	1	1.100	-	-	LDO	PTHR46295
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3277
SonicParanoid	1	1.000	-	-		X4826
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.940