DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9911 and Pdia3

DIOPT Version :9

Sequence 1:	NP_573111.1	Gene:	CG9911 / 32588	FlyBaseID:	FBgn0030734	Length:	412	Species:	Drosophila melanogaster
Sequence 2:	NP_031978.2	Gene:	Pdia3 / 14827	MGIID:	95834	Length:	505	Species:	Mus musculus

Alignment Length:	452	Identity:	119/452 - (26%)
Similarity:	199/452 - (44%)	Gaps:	85/452 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 CVALV-AILQLLQYTQPADAAGAVPMTSDNIDMTLA---SNELVFLNFYAEWCRFSNILAPIFAE 74
            |:||: .:..||...:.|.|:..:.:|.:|.:..::   |..|:.:.|:|.||.....|||.:..
Mouse     5 CLALLPGVALLLASARLAAASDVLELTDENFESRVSDTGSAGLMLVEFFAPWCGHCKRLAPEYEA 69

  Fly    75 AADKIKEEFPEAGKVVLGKVDCDKETAIASRFHINKYPTLKIVRNGQLSKREYRGQRSAEAFLEF 139
            ||.::|      |.|.|.||||...|...:::.::.||||||.|:|: ....|.|.|:|:..:..
Mouse    70 AATRLK------GIVPLAKVDCTANTNTCNKYGVSGYPTLKIFRDGE-EAGAYDGPRTADGIVSH 127

  Fly   140 VKKQ---------LEDPIQEFKSLKDLENLDSKKRLILGYFDRRDQPEYDIFRKVATNLKEDCQF 195
            :|||         .|:..::|.|.||..        ::|:|.......:..|.|.|:||:::.:|
Mouse   128 LKKQAGPASVPLRTEEEFKKFISDKDAS--------VVGFFRDLFSDGHSEFLKAASNLRDNYRF 184

  Fly   196 -HVGFGDAAQAMHPPGTPIIVFRPDVALSHENDET--YTGSLQNFDELKIWVQEKCVPLVREITF 257
             |.......:.....|..|.:|||....:...|:|  ||.......::|.::|:....|...:|.
Mouse   185 AHTNIESLVKEYDDNGEGITIFRPLHLANKFEDKTVAYTEKKMTSGKIKKFIQDSIFGLCPHMTE 249

  Fly   258 ENAEELTEEGLPFLILFHHPTDH-------NSIKDYKSIIERQLLDEKQNVNFLTADGKRFAHPL 315
            :|.:.:..:.   |:..::..|:       |..::...::.::.||....:||..|..|.|:|.|
Mouse   250 DNKDLIQGKD---LLTAYYDVDYEKNAKGSNYWRNRVMMVAKKFLDAGHKLNFAVASRKTFSHEL 311

  Fly   316 HHLG--KSEDDLPLIAIDSFK--HMYLFPHFSDMYSPGK-LKQFLQDLYSGKLHR--------EF 367
            ...|  .:..::|::||.:.|  ...:...||   ..|| |:||||:.:.|.|.|        |.
Mouse   312 SDFGLESTTGEVPVVAIRTAKGEKFVMQEEFS---RDGKALEQFLQEYFDGNLKRYLKSEPIPES 373

  Fly   368 HYGP----------DPSNDIEPD-------PHTG--KGTSPPESKFKELGPSKHRYTLLEKD 410
            :.||          |..|:.:.|       |..|  |...|   |:||||..      |.||
Mouse   374 NEGPVKVVVAENFDDIVNEEDKDVLIEFYAPWCGHCKNLEP---KYKELGEK------LSKD 426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9911	NP_573111.1	PDI_a_ERp44	33..140	CDD:239294	34/109 (31%)
		PDI_b_ERp44	148..241	CDD:239368	22/95 (23%)
		Thioredoxin_6	171..357	CDD:290560	47/200 (24%)
		PDI_b'_ERp44	252..362	CDD:239370	28/121 (23%)
Pdia3	NP_031978.2	ER_PDI_fam	26..487	CDD:273457	112/431 (26%)
		Thioredoxin	27..131	CDD:278513	35/110 (32%)
		PDI_b_ERp57	135..240	CDD:239367	25/112 (22%)
		PDI_b'_ERp72_ERp57	244..357	CDD:239371	28/118 (24%)
		PDI_a_PDI_a'_C	377..480	CDD:239293	16/59 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	484..505
		Prevents secretion from ER. /evidence=ECO:0000250	502..505
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910