DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment caz and taf15

DIOPT Version :9

Sequence 1:	NP_523365.2	Gene:	caz / 32587	FlyBaseID:	FBgn0285954	Length:	399	Species:	Drosophila melanogaster
Sequence 2:	NP_001073442.1	Gene:	taf15 / 558760	ZFINID:	ZDB-GENE-061215-102	Length:	434	Species:	Danio rerio

Alignment Length:	486	Identity:	190/486 - (39%)
Similarity:	223/486 - (45%)	Gaps:	158/486 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 GGYGGGSG-----QGYNNFAVPPPNYQQMPNKTGNYNEPP-PNYGKQGG--------GYDSGS-- 52
            |||||..|     |||.           ..|.:|:|:|.. ..||:.||        ||.||.
Zfish    17 GGYGGSQGYQGGQQGYG-----------QGNGSGSYSEQSYGGYGQSGGDSYGQSSQGYSSGGYG 70

  Fly    53 ---------GHRGS-----------------GGSGNGGGGGGSWNDRGGNSYG---------NGG 82
                     |.:||                 |...:||||||.:....| |||         |.|
Zfish    71 QQQQGSDSYGQQGSESSSGYGDKSYGQQRSYGQQSSGGGGGGGYGQSSG-SYGGSQGGYGRRNDG 134

  Fly    83 ASK-----------DSY-NKGHGGYSGGG---GGGGG---GGGGGS-------GGNDMITQED-- 120
            .|:           :.| .:|.|||..||   ||.||   |.|||.       ||.....|:|
Zfish   135 DSRRFGDDEGSDRSEGYRGRGRGGYDRGGYDRGGRGGPPSGMGGGDRGGYKNYGGPKDYGQKDDD 199

  Fly   121 ---------TIFVSGMDPSTTEQDIETHFGAIGIIKKDKRTMKPKIWLYKNKETGASKGEATVTY 176
                     ||||.|:......|::..:|..|||||.:|:|.||.|.||.:|.||..||||||::
Zfish   200 GDQDNSDNNTIFVQGLGEDVNAQEVGDYFKQIGIIKVNKKTGKPMINLYSDKATGRLKGEATVSF 264

  Fly   177 DDTNAAQSAIEWFDGRDFNGNAIKVSLAQRQNNWNKGGGGGGGGGGRGGFGGRRGGGGGGGGGG- 240
            ||..:|::||:||||::|||..||||.|.|:..:.:.|||.||.||||||.||.||||||||||
Zfish   265 DDPPSAKAAIDWFDGKEFNGRPIKVSFATRRAEFTQRGGGSGGRGGRGGFRGRGGGGGGGGGGGF 329

  Fly   241 GGGGRFDRGGGGGGGRYDRGGGGGGGGGGGNVQPRDGDWKC--NSCNNTNFAWRNECNRCKTPKG 303
            |||..||                          .|.|||.|  :||.|.|||.|.|||||.|||
Zfish   330 GGGPSFD--------------------------VRGGDWPCPNSSCGNMNFARRYECNRCGTPK- 367

  Fly   304 DDEGSSGGGGGGGYGGGGGGGGYDRGNDRGSGGGGYHNRDRGGNSQGGGGGGGGGGGYSRFNDNN 368
             .||.|.|||||| ...|..|||  |.|.|..|||:    |||...|..||..|||||
Zfish   368 -PEGDSFGGGGGG-SDRGSRGGY--GGDHGDRGGGF----RGGRGGGFRGGDRGGGGY------- 417

  Fly   369 GGGRGGRGGGGGNRRDGGPMRNDGGMRSRPY 399
                  :.||.|:.||        ..|.|||
Zfish   418 ------KMGGRGDHRD--------DRRGRPY 434

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
caz	NP_523365.2	RRM	<118..>205	CDD:223796	46/97 (47%)
		RRM_SARFH	122..204	CDD:240978	43/81 (53%)
		zf-RanBP	275..304	CDD:279035	20/30 (67%)
		RanBP2-type Zn finger	279..298	CDD:275375	12/20 (60%)
taf15	NP_001073442.1	RRM	<209..>297	CDD:223796	46/87 (53%)
		RRM_FUS_TAF15	209..291	CDD:240979	43/81 (53%)
		zf-RanBP	338..368	CDD:279035	20/31 (65%)
		RanBP2-type Zn finger	342..363	CDD:275376	12/20 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588238
Domainoid	1	1.000	88	1.000	Domainoid score	I7897
eggNOG	1	0.900	-	-		E1_KOG1995
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	292	1.000	Inparanoid score	I2767
OMA	1	1.010	-	-		QHG49372
OrthoDB	1	1.010	-	-		D1539664at2759
OrthoFinder	1	1.000	-	-		FOG0002238
OrthoInspector	1	1.000	-	-		otm24413
orthoMCL	1	0.900	-	-		OOG6_109470
Panther	1	1.100	-	-	LDO	PTHR23238
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X712
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.810