DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment caz and fus

DIOPT Version :9

Sequence 1:	NP_523365.2	Gene:	caz / 32587	FlyBaseID:	FBgn0285954	Length:	399	Species:	Drosophila melanogaster
Sequence 2:	NP_957377.2	Gene:	fus / 394058	ZFINID:	ZDB-GENE-040426-1010	Length:	541	Species:	Danio rerio

Alignment Length:	453	Identity:	195/453 - (43%)
Similarity:	230/453 - (50%)	Gaps:	111/453 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 GGYGGGSGQ--GYN------------------------------NFAVPPP-NY-QQMPNKTGNY 34
            |||||..||  ||.                              |::.||| :| ||.....|.|
Zfish   143 GGYGGSGGQSGGYGSSGGQSSGFGGSGGQHQSSQSGGGSYSPSPNYSSPPPQSYGQQSQYGQGGY 207

  Fly    35 NE--PPPNYGKQGGGY---DSGSGHRGSGGSGNGGGGGGSWNDRGGNSYGNGGASKDSYNKGHGG 94
            |:  ||.:.|..||||   |.|....|.||.|.|||.||    ||...:..|         |.||
Zfish   208 NQDSPPMSGGGGGGGYGGQDGGYSQDGRGGRGRGGGFGG----RGAGGFDRG---------GRGG 259

  Fly    95 YSGGGGGGGGGGGG----------GSGGNDMITQE----DTIFVSGMDPSTTEQDIETHFGAIGI 145
            ..|.||.|.|..||          |:||.:|..|:    :||||.|:....|...:..:|..|||
Zfish   260 PRGRGGMGMGDRGGFNKFGGPRDHGAGGPNMQEQDNSDNNTIFVQGLGDDYTVDSVADYFKQIGI 324

  Fly   146 IKKDKRTMKPKIWLYKNKETGASKGEATVTYDDTNAAQSAIEWFDGRDFNGNAIKVSLAQRQNNW 210
            ||.:|:|..|.|.||.::|||..||||||::||..:|::||:||||:|||||.||||.|.|:..:
Zfish   325 IKVNKKTGLPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDWFDGKDFNGNPIKVSFATRRAEF 389

  Fly   211 NKGGGGGGGGGGRGGFGGRRGGGGGGGGGGGGGGRFDRGGGGGGGRYDRGGGGGGGGGGGNVQPR 275
            .:||..||..||||     |||..|.||.|||     ||||||||.:....|||.|.|||  |.|
Zfish   390 GRGGSSGGMRGGRG-----RGGPMGRGGFGGG-----RGGGGGGGGFQGNNGGGSGNGGG--QQR 442

  Fly   276 DGDWKCN--SCNNTNFAWRNECNRCKTPKGDDEGSSGGGG--GGGYGGGGGGGGYDRGNDRGSGG 336
            .|||||:  ||.|.||:||||||:||.||  .|||.||..  |||:||..|..|:|||..||.||
Zfish   443 AGDWKCSNPSCGNLNFSWRNECNQCKEPK--PEGSGGGMSPMGGGFGGERGRSGFDRGGFRGRGG 505

  Fly   337 GGYHNRDRGGNSQGGGGGGGGGGGYSRFNDNNGGGRGGRGGGGGNRRDGGPMRNDGGMRSRPY 399
                  ||||                 |....||.|||.|.|..:.|  |..|:|  .|.|||
Zfish   506 ------DRGG-----------------FRGGRGGDRGGFGPGKMDSR--GDHRHD--RRDRPY 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
caz	NP_523365.2	RRM	<118..>205	CDD:223796	46/90 (51%)
		RRM_SARFH	122..204	CDD:240978	44/81 (54%)
		zf-RanBP	275..304	CDD:279035	21/30 (70%)
		RanBP2-type Zn finger	279..298	CDD:275375	14/20 (70%)
fus	NP_957377.2	RRM	<274..>388	CDD:223796	52/113 (46%)
		RRM_FUS_TAF15	297..382	CDD:240979	44/84 (52%)
		zf-RanBP	443..472	CDD:279035	20/30 (67%)
		RanBP2-type Zn finger	446..467	CDD:275375	14/20 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588234
Domainoid	1	1.000	88	1.000	Domainoid score	I7897
eggNOG	1	0.900	-	-		E1_KOG1995
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	292	1.000	Inparanoid score	I2767
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1539664at2759
OrthoFinder	1	1.000	-	-		FOG0002238
OrthoInspector	1	1.000	-	-		otm24413
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23238
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4499
SonicParanoid	1	1.000	-	-		X712
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.890