DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment caz and RBMY1E

DIOPT Version :9

Sequence 1:	NP_523365.2	Gene:	caz / 32587	FlyBaseID:	FBgn0285954	Length:	399	Species:	Drosophila melanogaster
Sequence 2:	NP_001006118.2	Gene:	RBMY1E / 378950	HGNCID:	23916	Length:	496	Species:	Homo sapiens

Alignment Length:	338	Identity:	82/338 - (24%)
Similarity:	121/338 - (35%)	Gaps:	74/338 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 IFVSGMDPSTTEQDIETHFGAIGIIKKDKRTMKPKIWLYKNKETGASKGEATVTYDDTNAAQSAI 186
            :|:.|::..|.|:.::..||..|.|.        ::.|.|:: |..|:|.|.:|:::...|::|.
Human    10 LFIGGLNRETNEKMLKAVFGKHGPIS--------EVLLIKDR-TSKSRGFAFITFENPADAKNAA 65

  Fly   187 EWFDGRDFNGNAIKVSLAQRQNNWNKGG--GGGGGGGGRGGFGGRRGGGGGGGGGGG----GGGR 245
            :..:|:..:|.||||..|::. ::..||  ........|...|..|...|..||..|    ..|.
Human    66 KDMNGKSLHGKAIKVEQAKKP-SFQSGGRRRPPASSRNRSPSGSLRSARGSRGGTRGWLPSQEGH 129

  Fly   246 FDRGGGGGGGR--YDRG------GGGGGGGG------GGNVQPRDGDWKCN----SCNNTNF--- 289
            .|.||.....:  |.||      |.....||      ..:...|...|..:    |....|:
Human   130 LDDGGYTPDLKMSYSRGLIPVKRGPSSRSGGPPPKKSAPSAVARSNSWMGSQGPMSQRRENYGVP 194

  Fly   290 -------AWRNECNRCKTPKGDDEGSSGGGGGG-----GYGGGGGGGGY-DRG--NDRGSGGGGY 339
                   :|||:  |..| :.|...::.|....     .|.....|..| |.|  |.......||
Human   195 PRRATISSWRND--RMST-RHDGYATNDGNHPSCQETRDYAPPSRGYAYRDNGHSNRDEHSSRGY 256

  Fly   340 HN-------RDRGGNSQGGG----GGGGGGGGYSRFNDNNGGGRGGR-----GGGGGNRRDGGPM 388
            .|       ||....|:|..    |.......|||...|....|..|     ..|.|.|..|...
Human   257 RNHRSSRETRDYAPPSRGHAYRDYGHSRRDESYSRGYRNRRSSRETREYAPPSRGHGYRDYGHSR 321

  Fly   389 RNDG---GMRSRP 398
            |::.   |.|:.|
Human   322 RHESYSRGYRNHP 334

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
caz	NP_523365.2	RRM	<118..>205	CDD:223796	23/82 (28%)
		RRM_SARFH	122..204	CDD:240978	23/81 (28%)
		zf-RanBP	275..304	CDD:279035	9/42 (21%)
		RanBP2-type Zn finger	279..298	CDD:275375	6/32 (19%)
RBMY1E	NP_001006118.2	RRM	<1..189	CDD:223796	46/188 (24%)
		RRM_RBMX_like	7..85	CDD:240828	24/83 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	67..348		65/272 (24%)
		RBM1CTR	174..218	CDD:285341	9/46 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	453..496
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910