DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment caz and ewsr1b

DIOPT Version :9

Sequence 1:	NP_523365.2	Gene:	caz / 32587	FlyBaseID:	FBgn0285954	Length:	399	Species:	Drosophila melanogaster
Sequence 2:	XP_005165164.2	Gene:	ewsr1b / 322880	ZFINID:	ZDB-GENE-030131-1600	Length:	579	Species:	Danio rerio

Alignment Length:	443	Identity:	155/443 - (34%)
Similarity:	205/443 - (46%)	Gaps:	85/443 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ERGGYG----GGSGQGYNNFAVPPPNYQQMPNKT----GNYNEPPPNYGKQG---GGYDSGSGHR 55
            ::.|||    ...|||.     ||..:||.|...    |:.:.....||:|.   ..|.....:.
Zfish   177 QQPGYGQQQQSAYGQGQ-----PPQQHQQGPPAAYPPQGSSSYAQTQYGQQSAPQNDYQQNPYNS 236

  Fly    56 GSGGSGNGGGGG---GSWNDRGGNSYGNGGASKDSYNKGHGGYSGGGGGGGGGGGGGSGGND--- 114
            .|.|..:||..|   |.:.|.|.:.|..||.......:|..|.:|..||....||...||.|
Zfish   237 YSQGGVSGGYPGSQRGGYQDGGRDGYDRGGPRGRGMGRGGMGIAGDRGGFNKPGGPMRGGMDRDM 301

  Fly   115 -----MITQEDTIFVSGMDPSTTEQDIETHFGAIGIIKKDKRTMKPKIWLYKNKETGASKGEATV 174
                 ..::..||:::|:..:.|..::...|...|.|:.::|..:|.|.:|.:|::|..||:||:
Zfish   302 GHPGEQDSENSTIYITGLTENATLPEMAEFFKHTGAIRINRRLNQPAINIYTDKDSGKPKGDATL 366

  Fly   175 TYDDTNAAQSAIEWFDGRDFNGNAIKVSLAQRQNNWNKGGGGGGGGGGRGGFGGRRGGGGGGGGG 239
            :|::...|::|:|.|||::|.|..:|||:|:|:   ...||..||...|||.|..|||..|.||.
Zfish   367 SYEEPAFAKAAVEHFDGKEFQGRRLKVSMARRK---PMIGGMRGGMPMRGGPGMDRGGMMGRGGE 428

  Fly   240 GGGGGRFDRGGGGGGGRYDRGGGGGGGGGGGNVQPRDGDWKCNS--CNNTNFAWRNECNRCKTPK 302
            .||   |...||..||.     |..||...||||.|.|||:|.:  |.|.||:||.|||:||.||
Zfish   429 RGG---FPPRGGPRGGM-----GWNGGPQPGNVQKRAGDWECPNAGCGNQNFSWRMECNQCKAPK 485

  Fly   303 GDDEGSS---GGGGGGGYGGGGGGGGYDRGNDRGSGGGGYHNRDRGGNSQGGGGGGGGGGGYSRF 364
            .:..|:|   ..||..|.||..||.|.|||     |.||..           ||.||..||:.
Zfish   486 PEGLGTSPPFSPGGERGRGGMRGGRGMDRG-----GPGGMR-----------GGWGGDRGGFR-- 532

  Fly   365 NDNNGGGRGG--RGGGGGNRRDGGPM-RNDGGM---------------RSRPY 399
                  ||||  |||..|..|.|.|| |...||               |.|||
Zfish   533 ------GRGGMDRGGFRGGSRGGPPMDRGRRGMGPPGKMEMRDHRQERRERPY 579

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
caz	NP_523365.2	RRM	<118..>205	CDD:223796	29/86 (34%)
		RRM_SARFH	122..204	CDD:240978	28/81 (35%)
		zf-RanBP	275..304	CDD:279035	18/30 (60%)
		RanBP2-type Zn finger	279..298	CDD:275375	11/20 (55%)
ewsr1b	XP_005165164.2	RRM	<306..>397	CDD:223796	29/90 (32%)
		RRM_SF	312..395	CDD:302621	28/82 (34%)
		zf-RanBP	456..486	CDD:279035	17/29 (59%)
		RanBP2-type Zn finger	460..481	CDD:275375	11/20 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588235
Domainoid	1	1.000	54	1.000	Domainoid score	I11221
eggNOG	1	0.900	-	-		E1_KOG1995
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	292	1.000	Inparanoid score	I2767
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1539664at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm24413
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23238
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4499
SonicParanoid	1	1.000	-	-		X712
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.890