DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment caz and RBMX

DIOPT Version :9

Sequence 1:	NP_523365.2	Gene:	caz / 32587	FlyBaseID:	FBgn0285954	Length:	399	Species:	Drosophila melanogaster
Sequence 2:	NP_002130.2	Gene:	RBMX / 27316	HGNCID:	9910	Length:	391	Species:	Homo sapiens

Alignment Length:	343	Identity:	89/343 - (25%)
Similarity:	130/343 - (37%)	Gaps:	92/343 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 IFVSGMDPSTTEQDIETHFGAIGIIKKDKRTMKPKIWLYKNKETGASKGEATVTYDDTNAAQSAI 186
            :|:.|::..|.|:.:|..||..|.|        .::.|.|::||..|:|.|.||::....|:.|.
Human    10 LFIGGLNTETNEKALEAVFGKYGRI--------VEVLLMKDRETNKSRGFAFVTFESPADAKDAA 66

  Fly   187 EWFDGRDFNGNAIKVSLAQRQN--NWNKG--------GGGGGGGGGRGGFGGRRGGGGGGGGGGG 241
            ...:|:..:|.||||..|.:.:  :..:|        |...|..|||||.||.||....||....
Human    67 RDMNGKSLDGKAIKVEQATKPSFESGRRGPPPPPRSRGPPRGLRGGRGGSGGTRGPPSRGGHMDD 131

  Fly   242 GG------------------GRFDRGGG----------------GGGGRYDRGGGGGGGGGGGN- 271
            ||                  |...|.||                |.|||.....|....||...
Human   132 GGYSMNFNMSSSRGPLPVKRGPPPRSGGPPPKRSAPSGPVRSSSGMGGRAPVSRGRDSYGGPPRR 196

  Fly   272 ----------VQPRDGDWKC-NSCNNTNF-AWRNECNRCKTPKG------------DDEGSSGGG 312
                      :.|||..:.. :|.::.:: :.|:..:....|:.            ||..|.|..
Human   197 EPLPSRRDVYLSPRDDGYSTKDSYSSRDYPSSRDTRDYAPPPRDYTYRDYGHSSSRDDYPSRGYS 261

  Fly   313 GGGGYGGGGGGGGYDRG-NDRGSGGGGYHNRDRGGNSQGG---GGGGGGGGGYSRFNDNNGGGRG 373
            ...||       |.||. :|..|||....:.:..|||:..   .|.....||.||::|.:    .
Human   262 DRDGY-------GRDRDYSDHPSGGSYRDSYESYGNSRSAPPTRGPPPSYGGSSRYDDYS----S 315

  Fly   374 GRGGGGGNRRDGGPMRND 391
            .|.|.||:|......|:|
Human   316 SRDGYGGSRDSYSSSRSD 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
caz	NP_523365.2	RRM	<118..>205	CDD:223796	26/82 (32%)
		RRM_SARFH	122..204	CDD:240978	26/81 (32%)
		zf-RanBP	275..304	CDD:279035	5/42 (12%)
		RanBP2-type Zn finger	279..298	CDD:275375	2/20 (10%)
RBMX	NP_002130.2	RRM_RBMX_like	7..86	CDD:409816	27/83 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	61..391		71/284 (25%)
		dnaA	165..>306	CDD:237605	30/147 (20%)
		RBM1CTR	173..217	CDD:400429	10/43 (23%)
		Necessary for the association to nascent RNAPII transcripts and nuclear localization	186..236		8/49 (16%)
		Necessary for RNA-binding	333..391		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910