DRSC/TRiP Functional Genomics Resources

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Protein Alignment caz and FUS

DIOPT Version :9

Sequence 1:NP_523365.2 Gene:caz / 32587 FlyBaseID:FBgn0285954 Length:399 Species:Drosophila melanogaster
Sequence 2:NP_004951.1 Gene:FUS / 2521 HGNCID:4010 Length:526 Species:Homo sapiens


Alignment Length:461 Identity:195/461 - (42%)
Similarity:235/461 - (50%) Gaps:110/461 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 GGYGGGS-----GQGYNNFAVPPPNY---QQMPNKTGNYNEPPPNYGKQ--------GGGYDSGS 52
            |.||..|     ||..:......|:|   ||...:..:|| ||..||:|        |||...|.
Human   111 GSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYN-PPQGYGQQNQYNSSSGGGGGGGGG 174

  Fly    53 GHRG------SGGSGNGG--------GGGGS----WNDRG----GNSYGNGGASKDSYNKGHGGY 95
            |:.|      |.|.|:||        |||||    ..|||    |.|.|.||.....||:..|||
Human   175 GNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGY 239

  Fly    96 SGGGGGGGGGGGGGSGGNDM---------------------ITQEDTIFVSGMDPSTTEQDIETH 139
            ...|.|||.||.||.||:|.                     .:..:||||.|:..:.|.:.:..:
Human   240 EPRGRGGGRGGRGGMGGSDRGGFNKFGGPRDQGSRHDSEQDNSDNNTIFVQGLGENVTIESVADY 304

  Fly   140 FGAIGIIKKDKRTMKPKIWLYKNKETGASKGEATVTYDDTNAAQSAIEWFDGRDFNGNAIKVSLA 204
            |..|||||.:|:|.:|.|.||.::|||..||||||::||..:|::||:||||::|:||.||||.|
Human   305 FKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDWFDGKEFSGNPIKVSFA 369

  Fly   205 QRQNNWNKGGGGGGGGGGRGGFGGRRGGGGGGGGGGGGGGRFDRGGGGGGGRYDRGGGGGGGGGG 269
            .|:.::|:|||.|.||.||||..| |||.||||.||||.|.|..|||||||              
Human   370 TRRADFNRGGGNGRGGRGRGGPMG-RGGYGGGGSGGGGRGGFPSGGGGGGG-------------- 419

  Fly   270 GNVQPRDGDWKC--NSCNNTNFAWRNECNRCKTPKGDDEGSSGGGG--GGGYGGG--GGGGGYDR 328
               |.|.|||||  .:|.|.||:||||||:||.||.|..|...||.  ||.||..  ||.|||||
Human   420 ---QQRAGDWKCPNPTCENMNFSWRNECNQCKAPKPDGPGGGPGGSHMGGNYGDDRRGGRGGYDR 481

  Fly   329 GNDRGSGGGGYHNRDRGGNSQGGGGGGGGGGGYSRFNDNNGGGRGGRGGGGGNRRDGGPMRNDGG 393
            |..||.||      |||| .:||.|||          |..|.|.|.....|.:|:|         
Human   482 GGYRGRGG------DRGG-FRGGRGGG----------DRGGFGPGKMDSRGEHRQD--------- 520

  Fly   394 MRSRPY 399
            .|.|||
Human   521 RRERPY 526

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cazNP_523365.2 RRM <118..>205 CDD:223796 43/86 (50%)
RRM_SARFH 122..204 CDD:240978 42/81 (52%)
zf-RanBP 275..304 CDD:279035 20/30 (67%)
RanBP2-type Zn finger 279..298 CDD:275375 13/20 (65%)
FUSNP_004951.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..286 57/175 (33%)
RRM_FUS_TAF15 283..368 CDD:240979 42/84 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 375..424 34/66 (52%)
zf-RanBP 422..449 CDD:279035 17/26 (65%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 444..526 44/107 (41%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165153173
Domainoid 1 1.000 87 1.000 Domainoid score I7985
eggNOG 1 0.900 - - E1_KOG1995
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 295 1.000 Inparanoid score I2754
Isobase 1 0.950 - 0 Normalized mean entropy S1093
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1539664at2759
OrthoFinder 1 1.000 - - FOG0002238
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR23238
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4499
SonicParanoid 1 1.000 - - X712
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1312.840

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