DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment caz and Fus

DIOPT Version :9

Sequence 1:	NP_523365.2	Gene:	caz / 32587	FlyBaseID:	FBgn0285954	Length:	399	Species:	Drosophila melanogaster
Sequence 2:	NP_631888.1	Gene:	Fus / 233908	MGIID:	1353633	Length:	518	Species:	Mus musculus

Alignment Length:	450	Identity:	190/450 - (42%)
Similarity:	229/450 - (50%)	Gaps:	110/450 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ERGGYGGGSGQGYNNFAVPPPNYQQMPNKTGNYNEPPPNYGKQGGGYDSGSGHRGSGGSGN---- 62
            :.||||..||.|        ...|....:..:|| ||..||:| ..|:|.||..|.||.||
Mouse   127 QSGGYGQQSGYG--------GQQQSYGQQQSSYN-PPQGYGQQ-NQYNSSSGGGGGGGGGNYGQD 181

  Fly    63 -----GGGGGGSW-----------------NDRGGNSYGNGGASKDSYNKGHGGYSGGGGGGGGG 105
                 ||||||.:                 .||||...|.||    .||:..|||...|.|||.|
Mouse   182 QSSMSGGGGGGGYGNQDQSGGGGGGYGGGQQDRGGRGRGGGG----GYNRSSGGYEPRGRGGGRG 242

  Fly   106 GGGGSGGNDM---------------------ITQEDTIFVSGMDPSTTEQDIETHFGAIGIIKKD 149
            |.||.||:|.                     .:..:||||.|:..:.|.:.:..:|..|||||.:
Mouse   243 GRGGMGGSDRGGFNKFGGPRDQGSRHDSEQDNSDNNTIFVQGLGENVTIESVADYFKQIGIIKTN 307

  Fly   150 KRTMKPKIWLYKNKETGASKGEATVTYDDTNAAQSAIEWFDGRDFNGNAIKVSLAQRQNNWNKGG 214
            |:|.:|.|.||.::|||..||||||::||..:|::||:||||::|:||.||||.|.|:.::|:||
Mouse   308 KKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDWFDGKEFSGNPIKVSFATRRADFNRGG 372

  Fly   215 GGGGGGGGRGGFGGRRGGGGGGGGGGGGGGRFDRGGGGGGGRYDRGGGGGGGGGGGNVQPRDGDW 279
            |.|.||.||||..| |||.||||.||||.|.|..|||||||                 |.|.|||
Mouse   373 GNGRGGRGRGGPMG-RGGYGGGGSGGGGRGGFPSGGGGGGG-----------------QQRAGDW 419

  Fly   280 KC--NSCNNTNFAWRNECNRCKTPKGDDEGSSGGGG--GGGYGGG-GGGGGYDRGNDRGSGGGGY 339
            ||  .:|.|.||:||||||:||.||.|..|...||.  ||.||.. .|.||||||..||.||
Mouse   420 KCPNPTCENMNFSWRNECNQCKAPKPDGPGGGPGGSHMGGNYGDDRRGRGGYDRGGYRGRGG--- 481

  Fly   340 HNRDRGGNSQGGGGGGGGGGGYSRFNDNNGGGRGGRGGGGGNRRDGGPMRNDGGMRSRPY 399
               |||| .:||.|||          |..|.|.|.....|.:|:|         .|.|||
Mouse   482 ---DRGG-FRGGRGGG----------DRGGFGPGKMDSRGEHRQD---------RRERPY 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
caz	NP_523365.2	RRM	<118..>205	CDD:223796	43/86 (50%)
		RRM_SARFH	122..204	CDD:240978	42/81 (52%)
		zf-RanBP	275..304	CDD:279035	20/30 (67%)
		RanBP2-type Zn finger	279..298	CDD:275375	13/20 (65%)
Fus	NP_631888.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..279		53/165 (32%)
		RRM	<257..>367	CDD:223796	45/109 (41%)
		RRM_FUS_TAF15	276..361	CDD:240979	42/84 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	368..417		34/66 (52%)
		zf-RanBP	415..442	CDD:279035	17/26 (65%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	437..518		43/106 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843277
Domainoid	1	1.000	87	1.000	Domainoid score	I7978
eggNOG	1	0.900	-	-		E1_KOG1995
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	298	1.000	Inparanoid score	I2696
Isobase	1	0.950	-	0	Normalized mean entropy	S1093
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002238
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23238
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4499
SonicParanoid	1	1.000	-	-		X712
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.830