Protein Alignment caz and EWSR1

DIOPT Version :9

• Sequence 1: NP_523365.2
• Gene: caz / 32587
• FlyBaseID: FBgn0285954
• Length: 399
• Species: Drosophila melanogaster
• Sequence 2: XP_011528297.1
• Gene: EWSR1 / 2130
• HGNCID: 3508
• Length: 670
• Species: Homo sapiens
• Alignment Length: 465
• Identity: 179/465 - (38%)
• Similarity: 222/465 - (47%)
• Gaps: 84/465 - (18%)

  Fly     2 ERGGYGGGSGQGYNNFAVPPPNYQQMPNKTGNYNEPPPNYGKQGGGYDSGSGHRGSGGSGNG--G 64
            ::..||..|..|..    ||.:|   |.:||:|::.|..|.:|...|...|..|....|..|  |
Human   223 QQSSYGQQSSYGQQ----PPTSY---PPQTGSYSQAPSQYSQQSSSYGQQSSFRQDHPSSMGVYG 280

  Fly    65 GGGGSWNDRGGNSYGNGGASKDSYNKGHGGYSGG----GGGGGGGGGGGSGGN------------ 113
            ...|.::..|.|...:|   .|:..:|.||:..|    ||.|||.||.||.|.
Human   281 QESGGFSGPGENRSMSG---PDNRGRGRGGFDRGGMSRGGRGGGRGGMGSAGERGGFNKPGGPMD 342

  Fly   114 -------------DMITQEDTIFVSGMDPSTTEQDIETHFGAIGIIKKDKRTMKPKIWLYKNKET 165
                         |..:....|:|.|::.|.|..|:...|...|::|.:|||.:|.|.:|.:|||
Human   343 EGPDLDLGPPVDPDEDSDNSAIYVQGLNDSVTLDDLADFFKQCGVVKMNKRTGQPMIHIYLDKET 407

  Fly   166 GASKGEATVTYDDTNAAQSAIEWFDGRDFNGNAIKVSLAQRQNNWNKGGGGGGGGGGRGGFGGRR 230
            |..||:|||:|:|...|::|:|||||:||.|:.:|||||:::...|...||.....|||.....|
Human   408 GKPKGDATVSYEDPPTAKAAVEWFDGKDFQGSKLKVSLARKKPPMNSMRGGLPPREGRGMPPPLR 472

  Fly   231 GGGGGGGGGGGGGGRFDRGGGGGGGRYDRG--GGGGGGGGGGNVQPRDGDWK------------- 280
            ||.||.||.||..||....||..||...||  |..|...||||||.|.|||:
Human   473 GGPGGPGGPGGPMGRMGGRGGDRGGFPPRGPRGSRGNPSGGGNVQHRAGDWQCPNPSIGDFCCDV 537

  Fly   281 --CNSCNNTNFAWRNECNRCKTPK------------GDDEGSSGGGG-GGGYGG----GGGGGGY 326
              |..|.|.|||||.|||:||.||            |.|.|..|.|| .||.||    ||.||.:
Human   538 IVCRGCGNQNFAWRTECNQCKAPKPEGFLPPPFPPPGGDRGRGGPGGMRGGRGGLMDRGGPGGMF 602

  Fly   327 --DRGNDRGSGGGGYHNRDRGGNSQGGGGGGGGGGGYSRFNDNNGGGRGGRGGGGGNRRDGGPMR 389
              .||.|||...|| ...||||  .|||..||.||......:..||.||||||.|  :.|.|..|
Human   603 RGGRGGDRGGFRGG-RGMDRGG--FGGGRRGGPGGPPGPLMEQMGGRRGGRGGPG--KMDKGEHR 662

  Fly   390 NDGGMRSRPY 399
            .:  .|.|||
Human   663 QE--RRDRPY 670

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
caz	NP_523365.2	RRM	<118..>205	CDD:223796	40/86 (47%)
		RRM_SARFH	122..204	CDD:240978	39/81 (48%)
		zf-RanBP	275..304	CDD:279035	19/55 (35%)
		RanBP2-type Zn finger	279..298	CDD:275375	12/33 (36%)
EWSR1	XP_011528297.1	RRM	<351..>459	CDD:223796	44/107 (41%)
		RRM_EWS	362..445	CDD:240977	38/82 (46%)
		zf-RanBP	519..561	CDD:279035	17/41 (41%)
		RanBP2-type Zn finger	523..557	CDD:275375	12/33 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153174
Domainoid	1	1.000	87	1.000	Domainoid score	I7985
eggNOG	1	0.900	-	-		E1_KOG1995
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	295	1.000	Inparanoid score	I2754
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1539664at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41116
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23238
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4499
SonicParanoid	1	1.000	-	-		X712
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.890