DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eas and CKI1

DIOPT Version :9

Sequence 1:	NP_523364.2	Gene:	eas / 32585	FlyBaseID:	FBgn0000536	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_013234.1	Gene:	CKI1 / 850824	SGDID:	S000004123	Length:	582	Species:	Saccharomyces cerevisiae

Alignment Length:	336	Identity:	80/336 - (23%)
Similarity:	134/336 - (39%)	Gaps:	101/336 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   204 VLVRIYGNKTDLLIDRKAETQNFLLLHTYGLAPSLYATFKNGLVYEYVPGT-TLNTDSVLCPEIW 267
            :|:||||...|.:|||:.|.|....|....:.||||..|.||...:::..: ||..|.:...:..
Yeast   172 LLLRIYGPNIDNIIDREYELQILARLSLKNIGPSLYGCFVNGRFEQFLENSKTLTKDDIRNWKNS 236

  Fly   268 PLVARRMAEMHRKV------RKHGDSSATKPMPMIWKKTQSFLDLVPERFSDAEKHKRVKETFLP 326
            ..:||||.|:|..|      ||:|.:        .|:|...:|..:.:........|.::.:.
Yeast   237 QRIARRMKELHVGVPLLSSERKNGSA--------CWQKINQWLRTIEKVDQWVGDPKNIENSL-- 291

  Fly   327 IGRLREEFNKLYEY--------------LEALDSPIVFSHNDLLLGNVIYTQS-LNTVNF----- 371
               |.|.::|..:.              :|.::..::|.|||...||:::|.. :||.:.
Yeast   292 ---LCENWSKFMDIVDRYHKWLISQEQGIEQVNKNLIFCHNDAQYGNLLFTAPVMNTPSLYTAPS 353

  Fly   372 ---------------------------------------IDYEYADYNFQAFDIGNHFAE----- 392
                                                   ||:|||..|..|:|:.||.:|
Yeast   354 STSLTSQSSSLFPSSSNVIVDDIINPPKQEQSQDSKLVVIDFEYAGANPAAYDLANHLSEWMYDY 418

  Fly   393 -------MCGVDEVDYSRYPKREFQLQWLRVYLEEYLQRSNIQ---NDEVELLYVQVNQFALASH 447
                   .|..|     |||.:|..|.:|..|:...  |...:   ::||:.||..:.|:.....
Yeast   419 NNAKAPHQCHAD-----RYPDKEQVLNFLYSYVSHL--RGGAKEPIDEEVQRLYKSIIQWRPTVQ 476

  Fly   448 IFWTVWSLLQA 458
            :||::|::||:
Yeast   477 LFWSLWAILQS 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eas	NP_523364.2	ETNK_euk	126..478	CDD:270706	80/336 (24%)
CKI1	NP_013234.1	Choline_kin_N	94..144	CDD:367938
CKI1	NP_013234.1	ETNK_euk	148..556	CDD:270706	80/336 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346574
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3046
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000493
OrthoInspector	1	1.000	-	-		otm46544
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22603
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.790