DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eas and etnk1

DIOPT Version :9

Sequence 1:	NP_523364.2	Gene:	eas / 32585	FlyBaseID:	FBgn0000536	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	XP_689471.3	Gene:	etnk1 / 565971	ZFINID:	ZDB-GENE-030328-21	Length:	360	Species:	Danio rerio

Alignment Length:	399	Identity:	175/399 - (43%)
Similarity:	227/399 - (56%)	Gaps:	60/399 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 VPFVPIFVEEADVIQGAKELLKVIRPTWDLSHVEFKSFTDGITNKLVGCFHKEISKLNDENGGSY 158
            ||.:.:.|:|.|...||.:|:|.:||.|..|.|:.|:|||||||||:||:          .|||
Zfish    14 VPKLDVTVDEHDYRAGALKLIKTLRPHWKPSEVKMKTFTDGITNKLIGCY----------VGGS- 67

  Fly   159 LPIKTQGLSPVQSEDPVIIEKEDDDEFTDDRAADDGSPVQYSDNVVLVRIYGNKTDLLIDRKAET 223
                                                     ...|||||:|||||:|.:||:.|.
Zfish    68 -----------------------------------------MQEVVLVRVYGNKTELFVDRENEV 91

  Fly   224 QNFLLLHTYGLAPSLYATFKNGLVYEYVPGTTLNTDSVLCPEIWPLVARRMAEMHRKVRKHGDSS 288
            ::|.:|..:..||.||.||.|||.||::.|..|..:.:..|.|:..:||:||:.| .:..|   :
Zfish    92 KSFRVLQAHRCAPRLYCTFNNGLCYEFLQGVALEPEHIRSPAIFRHIARQMAKYH-AIHAH---N 152

  Fly   289 ATKPMPMIWKKTQSFLDLVPERFSDAEKHKRVKETFLPIGRLREEFNKLYEYLEALDSPIVFSHN 353
            ...|...:|.|...|..|||..|.|.|..:|:.........||:|...|.:.|..|.||:|..||
Zfish   153 GWVPQSGLWLKMSKFFSLVPSHFEDPEMDQRLNNEVPSAACLRDEMIWLQQNLSKLGSPVVLCHN 217

  Fly   354 DLLLGNVIYTQSLNTVNFIDYEYADYNFQAFDIGNHFAEMCGVDEVDYSRYPKREFQLQWLRVYL 418
            |||..|:||.|....|.|||||||.||:|||||||||.|..|::||||:.||.||.|:||||.||
Zfish   218 DLLCKNIIYNQKEGNVKFIDYEYAGYNYQAFDIGNHFNEFAGLNEVDYTLYPDRELQMQWLRAYL 282

  Fly   419 EEY----LQRSNIQNDEVELLYVQVNQFALASHIFWTVWSLLQAEHSTIDFDYVGYAFLRYNEYL 479
            |.|    .|.|.:.|.||||||||||:||||||.||.:|:|:||::||||||::|||.||:|:|.
Zfish   283 EAYKEYKSQGSQVSNTEVELLYVQVNRFALASHFFWGLWALIQAQYSTIDFDFLGYAVLRFNQYF 347

  Fly   480 ARKVEFLSL 488
            ..|.|.:||
Zfish   348 KMKPEVMSL 356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eas	NP_523364.2	ETNK_euk	126..478	CDD:270706	157/355 (44%)
etnk1	XP_689471.3	ETNK_euk	46..348	CDD:270706	158/357 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596133
Domainoid	1	1.000	185	1.000	Domainoid score	I3314
eggNOG	1	0.900	-	-		E1_COG0510
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10240
Inparanoid	1	1.050	308	1.000	Inparanoid score	I2606
OMA	1	1.010	-	-		QHG54545
OrthoDB	1	1.010	-	-		D301681at33208
OrthoFinder	1	1.000	-	-		FOG0000493
OrthoInspector	1	1.000	-	-		otm26189
orthoMCL	1	0.900	-	-		OOG6_101726
Panther	1	1.100	-	-	LDO	PTHR22603
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4066
SonicParanoid	1	1.000	-	-		X2241
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800