DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment eas and cka-2

DIOPT Version :9

Sequence 1:NP_523364.2 Gene:eas / 32585 FlyBaseID:FBgn0000536 Length:495 Species:Drosophila melanogaster
Sequence 2:NP_001024480.1 Gene:cka-2 / 180703 WormBaseID:WBGene00000510 Length:429 Species:Caenorhabditis elegans


Alignment Length:443 Identity:116/443 - (26%)
Similarity:171/443 - (38%) Gaps:122/443 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   108 QGAKELLKVIRPTWDL-------------SHVEFKSFTDGITNKLVGCFHKEISKLNDENGGSYL 159
            :|.||||.    |.||             :|:....|..|.. |.|...|..||::   .||...
 Worm    31 RGMKELLS----TMDLDTDANTIPELKERAHMLCARFLGGAW-KTVPLEHLRISRI---KGGMSN 87

  Fly   160 PIKTQGLSPVQSEDPVIIEKEDDDEFTDDRAADDGSPVQYSDNVVLVRIYGN---KTDLLIDRKA 221
            .:....||.|.                        .|::...|.||:|:|.|   ::.|:    |
 Worm    88 MLFLCRLSEVY------------------------PPIRNEPNKVLLRVYFNPETESHLV----A 124

  Fly   222 ETQNFLLLHTYGLAPSLYATFKNGLVYEYVPGTTLNTDSVLCPEIWPLVARRMAEMHRKVRKHGD 286
            |:..|.||....|.|.||..|..|.:.||:|...|:...:....:...:|:|:|::|:       
 Worm   125 ESVIFTLLSERHLGPKLYGIFSGGRLEEYIPSRPLSCHEISLAHMSTKIAKRVAKVHQ------- 182

  Fly   287 SSATKPMPMIWKKTQSFLDLVPERFS------DAEKHKRVKE-------TFLPIGRLREEFNKLY 338
                ..:| |||:.....:.:.....      |||....:.|       ..|.:.|   |...|.
 Worm   183 ----LEVP-IWKEPDYLCEALQRWLKQLTGTVDAEHRFDLPEECGVSSVNCLDLAR---ELEFLR 239

  Fly   339 EYLEALDSPIVFSHNDLLLGNVIY----------------TQ----SLNTVN-------FIDYEY 376
            .::....||:.|.||||..||::.                ||    ||:..|       .||:||
 Worm   240 AHISLSKSPVTFCHNDLQEGNILLPKASSGNIRMPSLSDETQALGNSLSAFNPADPRLVLIDFEY 304

  Fly   377 ADYNFQAFDIGNHFAEMC---GVDEVDY-----SRYPKREFQLQWLRVYLEEYLQRSNIQNDEV- 432
            |.||::|||..|||.|..   .:||..:     ..:|:.:..|::...||.|   :.|.:.:|: 
 Worm   305 ASYNYRAFDFANHFIEWTIDYDIDEAPFYKIQTENFPENDQMLEFFLNYLRE---QGNTRENELY 366

  Fly   433 ---ELLYVQVNQFALASHIFWTVWSLLQAEHSTIDFDYVGYAFLRYNEYLARK 482
               |.|..:...|...||.||.||.|||.|.|.:.|.:..|...|.:.|...|
 Worm   367 KKSEDLVQETLPFVPVSHFFWGVWGLLQVELSPVGFGFADYGRDRLSLYFKHK 419

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
easNP_523364.2 ETNK_euk 126..478 CDD:270706 105/406 (26%)
cka-2NP_001024480.1 PLN02236 64..422 CDD:177880 106/406 (26%)
ChoK_euk 76..420 CDD:270705 102/393 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S3046
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000493
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.860

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