DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prosalpha4 and pre6

DIOPT Version :9

Sequence 1:	NP_525092.1	Gene:	Prosalpha4 / 32584	FlyBaseID:	FBgn0004066	Length:	249	Species:	Drosophila melanogaster
Sequence 2:	NP_595165.1	Gene:	pre6 / 2540175	PomBaseID:	SPBC106.16	Length:	259	Species:	Schizosaccharomyces pombe

Alignment Length:	245	Identity:	130/245 - (53%)
Similarity:	185/245 - (75%)	Gaps:	3/245 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SRYDRAVTIFSPDGHLLQVEYAQEAVRKGSTAVGVRGANCVVLGVEKKSVAQLQEDRKVRKICML 67
            |.||||:::|||||.||||||.|||||:|:||:.:||..|:|:|||:|:|.:||.....:||.|:
pombe     2 SGYDRALSVFSPDGRLLQVEYGQEAVRRGTTAIALRGNECIVIGVERKNVPKLQNVSNFQKIAMV 66

  Fly    68 DNHVVMAFAGLTADARIMINRAQVECQSHRLNVEDPVTLEYITRFIAQLKQKYTQSNGRRPFGIS 132
            ||||.:|||||.|||||:|::|:||.|:|:||:.|||::||:||::|.::||||||.|.||||:|
pombe    67 DNHVCLAFAGLNADARILIDKARVEAQNHKLNLADPVSIEYLTRYVAGVQQKYTQSGGVRPFGVS 131

  Fly   133 CLIGGFD-ADGSAHLFQTEPSGIFYEYKANATGRSAKVVREFFEKSYREEEVANEHGAVKLAIRA 196
            .||.||| .|.:..::||||:||:..:||.|.||::|..||:.||:::|....:|  .:.||:.:
pombe   132 TLIAGFDVGDNTPRVYQTEPAGIYNAWKATAIGRASKAAREYLEKNWKEGLSRDE--TIHLAVSS 194

  Fly   197 LLEVAQSGQNNLEVAIMENGKPLKMLDTDVITDYVKIIEKEKEEELEKKK 246
            ||||.|:...|:|:|||:.||.::.|.:|.|...||.|:.|||.|..:||
pombe   195 LLEVVQTASGNIELAIMDPGKDVEFLHSDKIDTIVKEIQDEKEAEAARKK 244

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prosalpha4	NP_525092.1	PRK03996	5..231	CDD:235192	120/226 (53%)
Prosalpha4	NP_525092.1	proteasome_alpha_type_7	5..213	CDD:239724	113/208 (54%)
pre6	NP_595165.1	PRK03996	1..232	CDD:235192	123/231 (53%)
pre6	NP_595165.1	proteasome_alpha_type_7	4..211	CDD:239724	113/208 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	201	1.000	Domainoid score	I650
eggNOG	1	0.900	-	-		E1_COG0638
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2086
Inparanoid	1	1.050	265	1.000	Inparanoid score	I730
OMA	1	1.010	-	-		QHG62217
OrthoFinder	1	1.000	-	-		FOG0002043
OrthoInspector	1	1.000	-	-		otm47071
orthoMCL	1	0.900	-	-		OOG6_101207
Panther	1	1.100	-	-	LDO	PTHR11599
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2243
SonicParanoid	1	1.000	-	-		X1345
TreeFam	1	0.960	-	-
	14	13.860