DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prosalpha4 and pas-4

DIOPT Version :9

Sequence 1:	NP_525092.1	Gene:	Prosalpha4 / 32584	FlyBaseID:	FBgn0004066	Length:	249	Species:	Drosophila melanogaster
Sequence 2:	NP_492360.1	Gene:	pas-4 / 172679	WormBaseID:	WBGene00003925	Length:	253	Species:	Caenorhabditis elegans

Alignment Length:	252	Identity:	144/252 - (57%)
Similarity:	195/252 - (77%)	Gaps:	8/252 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SRYDRAVTIFSPDGHLLQVEYAQEAVRKGSTAVGVRGANCVVLGVEKKSVAQLQEDRKVRKICML 67
            :|||||:|||||||||.|||||||||:||||||||||.:|:|:||||||:..||:||.:|||.|:
Worm     2 NRYDRAITIFSPDGHLFQVEYAQEAVKKGSTAVGVRGKDCIVIGVEKKSIPALQDDRTIRKIHMI 66

  Fly    68 DNHVVMAFAGLTADARIMINRAQVECQSHRLNVEDPVTLEYITRFIAQLKQKYTQSNGRRPFGIS 132
            |:||::|||||:||||::::||::||||::|.:|||||:.||:|:||..||::|||.||||||||
Worm    67 DDHVMLAFAGLSADARVLVDRARIECQSYKLTLEDPVTVAYISRYIANTKQRFTQSPGRRPFGIS 131

  Fly   133 CLIGGFDADGSAHLFQTEPSGIFYEYKANATGRSAKVVREFFEKSYREEEVANEHGAVKLAIRAL 197
            .||||||.||:..||:|||||.:|||.||||||..|.|||:.|:.|.||...:|...:||.:::|
Worm   132 MLIGGFDHDGTPRLFKTEPSGAYYEYVANATGRGEKPVREYLEEQYSEENTVDEATTLKLVVKSL 196

  Fly   198 LEVAQSGQNNLEVAIME---NGKPLKMLDTDVITDYVKIIEKEK-----EEELEKKK 246
            .:|...|..|:|:|:|:   :....::|.|:.|...:|::|.|:     ||...|||
Worm   197 AQVVPPGSQNIEIAVMKKVNDELQQRVLSTEEIEALLKVVETERVAAEAEEAASKKK 253

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prosalpha4	NP_525092.1	PRK03996	5..231	CDD:235192	135/228 (59%)
Prosalpha4	NP_525092.1	proteasome_alpha_type_7	5..213	CDD:239724	131/207 (63%)
pas-4	NP_492360.1	PRK03996	4..234	CDD:235192	135/229 (59%)
pas-4	NP_492360.1	proteasome_alpha_type_7	4..212	CDD:239724	131/207 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160164109
Domainoid	1	1.000	240	1.000	Domainoid score	I1259
eggNOG	1	0.900	-	-		E1_COG0638
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	297	1.000	Inparanoid score	I1652
Isobase	1	0.950	-	0	Normalized mean entropy	S208
OMA	1	1.010	-	-		QHG62217
OrthoDB	1	1.010	-	-		D1222564at2759
OrthoFinder	1	1.000	-	-		FOG0002043
OrthoInspector	1	1.000	-	-		otm14312
orthoMCL	1	0.900	-	-		OOG6_101207
Panther	1	1.100	-	-	LDO	PTHR11599
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2243
SonicParanoid	1	1.000	-	-		X1345
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.790