DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prosalpha4 and PSMA8

DIOPT Version :9

Sequence 1:	NP_525092.1	Gene:	Prosalpha4 / 32584	FlyBaseID:	FBgn0004066	Length:	249	Species:	Drosophila melanogaster
Sequence 2:	NP_653263.2	Gene:	PSMA8 / 143471	HGNCID:	22985	Length:	256	Species:	Homo sapiens

Alignment Length:	255	Identity:	177/255 - (69%)
Similarity:	209/255 - (81%)	Gaps:	7/255 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSSRYDRAVTIFSPDGHLLQVEYAQEAVRKGSTAVGVRGANCVVLGVEKKSVAQLQEDRKVRKIC 65
            |:||||||:|:|||||||.|||||||||:|||||||:||.|.|||||||||||:||::|.|||||
Human     1 MASRYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGIRGTNIVVLGVEKKSVAKLQDERTVRKIC 65

  Fly    66 MLDNHVVMAFA------GLTADARIMINRAQVECQSHRLNVEDPVTLEYITRFIAQLKQKYTQSN 124
            .||:||.||||      |||||||::||||:||||||:|.||||||:||||||||.|||||||||
Human    66 ALDDHVCMAFAVLTIFIGLTADARVVINRARVECQSHKLTVEDPVTVEYITRFIATLKQKYTQSN 130

  Fly   125 GRRPFGISCLIGGFDADGSAHLFQTEPSGIFYEYKANATGRSAKVVREFFEKSYREEEVANEHGA 189
            ||||||||.||.|||.||.:.|:||:|||.::.:||||.|||||.||||.||:|.|:.:|::..|
Human   131 GRRPFGISALIVGFDDDGISRLYQTDPSGTYHAWKANAIGRSAKTVREFLEKNYTEDAIASDSEA 195

  Fly   190 VKLAIRALLEVAQSGQNNLEVAIMENGKPLKMLDTDVITDYVKIIEKEKEEELEKKKQKK 249
            :||||:|||||.|||..|:|:||:...:||||.....:..||..||||| ||.||||.||
Human   196 IKLAIKALLEVVQSGGKNIELAIIRRNQPLKMFSAKEVELYVTEIEKEK-EEAEKKKSKK 254

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prosalpha4	NP_525092.1	PRK03996	5..231	CDD:235192	159/231 (69%)
Prosalpha4	NP_525092.1	proteasome_alpha_type_7	5..213	CDD:239724	154/213 (72%)
PSMA8	NP_653263.2	PRK03996	5..237	CDD:235192	159/231 (69%)
PSMA8	NP_653263.2	proteasome_alpha_type_7	5..219	CDD:239724	154/213 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	267	1.000	Domainoid score	I1879
eggNOG	1	0.900	-	-		E1_COG0638
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2086
Inparanoid	1	1.050	346	1.000	Inparanoid score	I2313
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62217
OrthoDB	1	1.010	-	-		D1222564at2759
OrthoFinder	1	1.000	-	-		FOG0002043
OrthoInspector	1	1.000	-	-		mtm8580
orthoMCL	1	0.900	-	-		OOG6_101207
Panther	1	1.100	-	-	LDO	PTHR11599
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2243
SonicParanoid	1	1.000	-	-		X1345
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.870