DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prosalpha4 and PSMB11

DIOPT Version :9

Sequence 1:	NP_525092.1	Gene:	Prosalpha4 / 32584	FlyBaseID:	FBgn0004066	Length:	249	Species:	Drosophila melanogaster
Sequence 2:	NP_001093250.1	Gene:	PSMB11 / 122706	HGNCID:	31963	Length:	300	Species:	Homo sapiens

Alignment Length:	189	Identity:	36/189 - (19%)
Similarity:	71/189 - (37%)	Gaps:	21/189 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 KICMLDNHVVMAFAGLTADARIMINRAQVECQSHRLNVEDPVTLEYITRFIAQLKQKYTQSNGRR 127
            |:..:..|::...:|.:||........|.|.:...|......::....:.::.:..:|.
Human    82 KVIPVHQHLLGTTSGTSADCATWYRVLQRELRLRELREGQLPSVASAAKLLSAMMSQYR------ 140

  Fly   128 PFGISCLIG----GFDADGSAHLFQTEPSGIFYEYKANATGRSAKVVREFFEKSYREEEVANE-H 187
              |:...:.    |:|..| ..||.....|...:....:.|..:.......::.||.:....| :
Human   141 --GLDLCVATALCGWDRSG-PELFYVYSDGTRLQGDIFSVGSGSPYAYGVLDRGYRYDMSTQEAY 202

  Fly   188 GAVKLAI-RALLEVAQSGQNNLEVAIMENG-KPLKMLDTDVITDYV---KIIEKEKEEE 241
            ...:.|: .|....|.||.:.....:.|:| :.:...|..|:  ||   |::|.|.||:
Human   203 ALARCAVAHATHRDAYSGGSVDLFHVRESGWEHVSRSDACVL--YVELQKLLEPEPEED 259

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prosalpha4	NP_525092.1	PRK03996	5..231	CDD:235192	29/174 (17%)
Prosalpha4	NP_525092.1	proteasome_alpha_type_7	5..213	CDD:239724	25/155 (16%)
PSMB11	NP_001093250.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		proteasome_beta_type_5	50..237	CDD:239730	27/163 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	255..300		3/5 (60%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0638
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900