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Protein Alignment Mfe2 and Hsd17b4

DIOPT Version :9

Sequence 1:	NP_001285318.1	Gene:	Mfe2 / 32582	FlyBaseID:	FBgn0030731	Length:	598	Species:	Drosophila melanogaster
Sequence 2:	NP_077368.2	Gene:	Hsd17b4 / 79244	RGDID:	621806	Length:	735	Species:	Rattus norvegicus

Alignment Length:	612	Identity:	327/612 - (53%)
Similarity:	426/612 - (69%)	Gaps:	40/612 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LRYDGRVAVVTGAGAGLGREYALLFAERGAKVVVNDLGGTHSGDGASQRAADIVVDEIRKAGGEA 72
            ||:||||.:|||||.||||.|||.||||||.||||||||...|.|....|||.||:|||:.||:|
  Rat     5 LRFDGRVVLVTGAGGGLGRAYALAFAERGALVVVNDLGGDFKGVGKGSSAADKVVEEIRRRGGKA 69

  Fly    73 VADYNSVIDGAKVIETAIKAFGRVDILVNNAGILRDRSLVKTSEQDWNLVNDVHLKGSFKCTQAA 137
            ||:|:||..|.|:::||:..|||:|::|||||||||||..:.|::||:::..|||:|||:.|:||
  Rat    70 VANYDSVEAGEKLVKTALDTFGRIDVVVNNAGILRDRSFSRISDEDWDIIQRVHLRGSFQVTRAA 134

  Fly   138 FPYMKKQNYGRIIMTSSNSGIYGNFGQVNYTAAKMGLIGLANTVAIEGARNNVLCNVIVPTAASR 202
            :.:||||||||||||:|.|||||||||.||:|||:||:|||||:.|||.:||:.||.|.|.|.||
  Rat   135 WDHMKKQNYGRIIMTASASGIYGNFGQANYSAAKLGLLGLANTLVIEGRKNNIHCNTIAPNAGSR 199

  Fly   203 MTEGILPDILFNELKPKLIAPVVAYLCHESCEDNGSYIESAAGWATKLHMVRGKGAVLRPSLDDP 267
            |||.::|:.|...|||:.:||:|.:|||||||:||...|..|||..||...|..||::| ..:.|
  Rat   200 MTETVMPEDLVEALKPEYVAPLVLWLCHESCEENGGLFEVGAGWIGKLRWERTLGAIVR-KRNQP 263

  Fly   268 VTIEYVKDVWSNVTDMSKAKHLGAIAEASGTLLEVLEKL-KEG------GGDAIEDA-------- 317
            :|.|.|:|.|..:.|.|.|....:|.|::|.::|||.|: .||      |..|..||
  Rat   264 MTPEAVRDNWVKICDFSNASKPKSIQESTGGIIEVLHKIDSEGISQNHTGQVASADASGFAGVVG 328

  Fly   318 -----FEFNSKEL--ITYALGIGASVKNAKDMRFLYENDADFAAIPTFFVLPGLLLQMSTDKLLS 375
                 |..:..||  |.||||:||||||.||::|:||..|||:.:|||.|:      ::...|:|
  Rat   329 HKLPSFSSSYTELQCIMYALGVGASVKNPKDLKFVYEGSADFSCLPTFGVI------VAQKSLMS 387

  Fly   376 KAL---PNSQVDFSNILHGEQYLEIVDDLPTSGTLLTNGKVFDVMDKGSGAVVVTNSESFDESGR 437
            ..|   |...::|:.:||||||||:...||.||.|.....:.|::|||||.|:|.:..|:  ||:
  Rat   388 GGLAEVPGLSINFAKVLHGEQYLELYKPLPRSGELKCEAVIADILDKGSGIVIVMDVYSY--SGK 450

  Fly   438 -LLVRNQSTTFIVGAGKFGGKK--DPIAGVVPLQPAPNRQPDATVQYTTSEDQAALYRLSGDKNP 499
             |:..||.:.|:||:|.||||:  :.:...|.:   |:|.|||.::.|||.:||||||||||.||
  Rat   451 ELICYNQFSVFVVGSGGFGGKRTSEKLKAAVAV---PSRPPDAVLRDTTSLNQAALYRLSGDSNP 512

  Fly   500 LHIDPQMALLAGFKTPILHGLCTLGFSVRAVLAQFADNNPALFKAVKVRFSGPVIPGQTLRVDLW 564
            |||||..|.:|||:.||||||||.|||.|.||.|||||:.:.|||:||||:.||.|||||:.::|
  Rat   513 LHIDPSFASIAGFEKPILHGLCTFGFSARHVLQQFADNDVSRFKAIKVRFAKPVYPGQTLQTEMW 577

  Fly   565 KQGTRINFRTVVVETGKEVISGAYVDL 591
            |:|.||:|:|.|.|||..|||.|||||
  Rat   578 KEGNRIHFQTKVQETGDIVISNAYVDL 604

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.