DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mfe2 and Hsd17b4

DIOPT Version :10

Sequence 1:NP_573109.1 Gene:Mfe2 / 32582 FlyBaseID:FBgn0030731 Length:598 Species:Drosophila melanogaster
Sequence 2:NP_077368.2 Gene:Hsd17b4 / 79244 RGDID:621806 Length:735 Species:Rattus norvegicus


Alignment Length:612 Identity:327/612 - (53%)
Similarity:426/612 - (69%) Gaps:40/612 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 LRYDGRVAVVTGAGAGLGREYALLFAERGAKVVVNDLGGTHSGDGASQRAADIVVDEIRKAGGEA 72
            ||:||||.:|||||.||||.|||.||||||.||||||||...|.|....|||.||:|||:.||:|
  Rat     5 LRFDGRVVLVTGAGGGLGRAYALAFAERGALVVVNDLGGDFKGVGKGSSAADKVVEEIRRRGGKA 69

  Fly    73 VADYNSVIDGAKVIETAIKAFGRVDILVNNAGILRDRSLVKTSEQDWNLVNDVHLKGSFKCTQAA 137
            ||:|:||..|.|:::||:..|||:|::|||||||||||..:.|::||:::..|||:|||:.|:||
  Rat    70 VANYDSVEAGEKLVKTALDTFGRIDVVVNNAGILRDRSFSRISDEDWDIIQRVHLRGSFQVTRAA 134

  Fly   138 FPYMKKQNYGRIIMTSSNSGIYGNFGQVNYTAAKMGLIGLANTVAIEGARNNVLCNVIVPTAASR 202
            :.:||||||||||||:|.|||||||||.||:|||:||:|||||:.|||.:||:.||.|.|.|.||
  Rat   135 WDHMKKQNYGRIIMTASASGIYGNFGQANYSAAKLGLLGLANTLVIEGRKNNIHCNTIAPNAGSR 199

  Fly   203 MTEGILPDILFNELKPKLIAPVVAYLCHESCEDNGSYIESAAGWATKLHMVRGKGAVLRPSLDDP 267
            |||.::|:.|...|||:.:||:|.:|||||||:||...|..|||..||...|..||::| ..:.|
  Rat   200 MTETVMPEDLVEALKPEYVAPLVLWLCHESCEENGGLFEVGAGWIGKLRWERTLGAIVR-KRNQP 263

  Fly   268 VTIEYVKDVWSNVTDMSKAKHLGAIAEASGTLLEVLEKL-KEG------GGDAIEDA-------- 317
            :|.|.|:|.|..:.|.|.|....:|.|::|.::|||.|: .||      |..|..||        
  Rat   264 MTPEAVRDNWVKICDFSNASKPKSIQESTGGIIEVLHKIDSEGISQNHTGQVASADASGFAGVVG 328

  Fly   318 -----FEFNSKEL--ITYALGIGASVKNAKDMRFLYENDADFAAIPTFFVLPGLLLQMSTDKLLS 375
                 |..:..||  |.||||:||||||.||::|:||..|||:.:|||.|:      ::...|:|
  Rat   329 HKLPSFSSSYTELQCIMYALGVGASVKNPKDLKFVYEGSADFSCLPTFGVI------VAQKSLMS 387

  Fly   376 KAL---PNSQVDFSNILHGEQYLEIVDDLPTSGTLLTNGKVFDVMDKGSGAVVVTNSESFDESGR 437
            ..|   |...::|:.:||||||||:...||.||.|.....:.|::|||||.|:|.:..|:  ||:
  Rat   388 GGLAEVPGLSINFAKVLHGEQYLELYKPLPRSGELKCEAVIADILDKGSGIVIVMDVYSY--SGK 450

  Fly   438 -LLVRNQSTTFIVGAGKFGGKK--DPIAGVVPLQPAPNRQPDATVQYTTSEDQAALYRLSGDKNP 499
             |:..||.:.|:||:|.||||:  :.:...|.:   |:|.|||.::.|||.:||||||||||.||
  Rat   451 ELICYNQFSVFVVGSGGFGGKRTSEKLKAAVAV---PSRPPDAVLRDTTSLNQAALYRLSGDSNP 512

  Fly   500 LHIDPQMALLAGFKTPILHGLCTLGFSVRAVLAQFADNNPALFKAVKVRFSGPVIPGQTLRVDLW 564
            |||||..|.:|||:.||||||||.|||.|.||.|||||:.:.|||:||||:.||.|||||:.::|
  Rat   513 LHIDPSFASIAGFEKPILHGLCTFGFSARHVLQQFADNDVSRFKAIKVRFAKPVYPGQTLQTEMW 577

  Fly   565 KQGTRINFRTVVVETGKEVISGAYVDL 591
            |:|.||:|:|.|.|||..|||.|||||
  Rat   578 KEGNRIHFQTKVQETGDIVISNAYVDL 604

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mfe2NP_573109.1 hydroxyacyl-CoA-like_DH_SDR_c-like 8..257 CDD:187611 154/248 (62%)
PLN02864 315..598 CDD:178455 150/298 (50%)
Hsd17b4NP_077368.2 (3R)-hydroxyacyl-CoA dehydrogenase 1..305 173/300 (58%)
hydroxyacyl-CoA-like_DH_SDR_c-like 5..254 CDD:187611 154/248 (62%)
Enoyl-CoA hydratase 2 321..621 148/295 (50%)
PLN02864 326..604 CDD:178455 146/288 (51%)
SCP2 627..730 CDD:460423
Microbody targeting signal. /evidence=ECO:0000255 733..735
Blue background indicates that the domain is not in the aligned region.

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