Protein Alignment Mfe2 and hsd17b4

DIOPT Version :9

• Sequence 1: NP_001285318.1
• Gene: Mfe2 / 32582
• FlyBaseID: FBgn0030731
• Length: 598
• Species: Drosophila melanogaster
• Sequence 2: NP_001027490.1
• Gene: hsd17b4 / 613082
• XenbaseID: XB-GENE-1010432
• Length: 740
• Species: Xenopus tropicalis
• Alignment Length: 619
• Identity: 299/619 - (48%)
• Similarity: 408/619 - (65%)
• Gaps: 37/619 - (5%)

  Fly     8 LRYDGRVAVVTGAGAGLGREYALLFAERGAKVVVNDLGGTHSGDGASQRAADIVVDEIRKAGGEA 72
            ||:||||.:|||||.||||.|||.||||||.|:||||||...|:|.|..|||.||:|||..||:|
 Frog     6 LRFDGRVVLVTGAGGGLGRTYALAFAERGASVIVNDLGGDIKGEGKSSSAADKVVEEIRAKGGKA 70

  Fly    73 VADYNSVIDGAKVIETAIKAFGRVDILVNNAGILRDRSLVKTSEQDWNLVNDVHLKGSFKCTQAA 137
            ||:|:||..|.|:::||:.||||:||:|||||||||||..:.|:.||::::.|||||:|..|:||
 Frog    71 VANYDSVEAGEKLVQTALDAFGRIDIVVNNAGILRDRSFARISDADWDIIHRVHLKGAFLITRAA 135

  Fly   138 FPYMKKQNYGRIIMTSSNSGIYGNFGQVNYTAAKMGLIGLANTVAIEGARNNVLCNVIVPTAASR 202
            :.:||.|.:||||||||.:||||||||.||:|||:||:||:||:||||.:.|:..|.|.|||.||
 Frog   136 WNHMKNQKFGRIIMTSSAAGIYGNFGQANYSAAKLGLVGLSNTLAIEGTKYNIHSNCIAPTAGSR 200

  Fly   203 MTEGILPDILFNELKPKLIAPVVAYLCHESCEDNGSYIESAAGWATKLHMVRGKGAVLRPSLDDP 267
            :|:.::|..|.:.|||:.:.|:|.:||||||::.||..|..|||..||...|..||::|.. :.|
 Frog   201 LTQTVMPQDLLDALKPEYVTPLVLWLCHESCQETGSLFEVGAGWVGKLRWERSLGAIIRQK-NRP 264

  Fly   268 VTIEYVKDVWSNVTDMSKAKHLGAIAEASGTLLEVLEKLKEGGG-----------------DAIE 315
            :|.|.|:|.|:.::|...|.....|.::...|.:||.:.....|                 |.::
 Frog   265 MTPEAVRDEWAKISDFDNADKPQTIQDSINPLYQVLSQTDSEKGMSMNPTSQGTSLSTSSIDPVK 329

  Fly   316 --------DAFEFNSKELITYALGIGASVKNAKDMRFLYENDADFAAIPTFFVLPGLLLQMSTDK 372
                    ..:.::..|.|.||||:|.|.::...::||||...||:.:|:|.|:      :|...
 Frog   330 AIGQKLPLTTYTYSHLEPILYALGVGMSTRDPDHLKFLYEGSEDFSCLPSFGVI------VSQAA 388

  Fly   373 LLSKAL---PNSQVDFSNILHGEQYLEIVDDLPTSGTLLTNGKVFDVMDKGSGAVVVTNSESFDE 434
            .:|..|   |...:||:.:|||||||||...|||||.:.::..|.|:|||||||:::.:..:: .
 Frog   389 FMSGGLASVPGLNIDFTRVLHGEQYLEIYKPLPTSGEMTSHATVADIMDKGSGAIILLDVHTY-H 452

  Fly   435 SGRLLVRNQSTTFIVGAGKFGGKKDPIAGVVPLQPAPNRQPDATVQYTTSEDQAALYRLSGDKNP 499
            ...|:..||.:.|:||||.||||:..........| |:|.||..|...|:.|||||||||||.||
 Frog   453 GVDLVCYNQFSVFVVGAGGFGGKRSSSKAKATANP-PSRPPDVVVTDATNADQAALYRLSGDWNP 516

  Fly   500 LHIDPQMALLAGFKTPILHGLCTLGFSVRAVLAQFADNNPALFKAVKVRFSGPVIPGQTLRVDLW 564
            |||||..|.:.||:.|||||||:.|||.|.||..||:|:...|||:||||:.||:|||||:.::|
 Frog   517 LHIDPSFAAMGGFEKPILHGLCSFGFSARHVLKHFANNDVTKFKAIKVRFAKPVLPGQTLQTEMW 581

  Fly   565 KQGTRINFRTVVVETGKEVISGAYVDLKSSQAKL 598
            |:|.||..:|.|.:||:..|:||||||.|::..|
 Frog   582 KEGNRIFLQTKVKDTGEIAIAGAYVDLTSTENNL 615

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mfe2	NP_001285318.1	hydroxyacyl-CoA-like_DH_SDR_c-like	8..257	CDD:187611	148/248 (60%)
		PRK07791	11..248	CDD:236099	143/236 (61%)
		PLN02864	315..598	CDD:178455	133/293 (45%)
		hot_dog	<383..442	CDD:294345	26/58 (45%)
		HDE_HSD	471..592	CDD:239532	72/120 (60%)
hsd17b4	NP_001027490.1	hydroxyacyl-CoA-like_DH_SDR_c-like	6..255	CDD:187611	148/248 (60%)
		PLN02864	318..615	CDD:178455	134/304 (44%)
		SCP2	632..735	CDD:376720

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	233	1.000	Domainoid score	I2357
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H358
Inparanoid	1	1.050	553	1.000	Inparanoid score	I1106
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1120431at2759
OrthoFinder	1	1.000	-	-		FOG0005261
OrthoInspector	1	1.000	-	-		oto104754
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2120
SonicParanoid	1	1.000	-	-		X3784
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	9.090