Protein Alignment Mfe2 and hsd17b4

DIOPT Version :9

• Sequence 1: NP_001285318.1
• Gene: Mfe2 / 32582
• FlyBaseID: FBgn0030731
• Length: 598
• Species: Drosophila melanogaster
• Sequence 2: XP_021333882.1
• Gene: hsd17b4 / 393105
• ZFINID: ZDB-GENE-040421-1
• Length: 749
• Species: Danio rerio
• Alignment Length: 604
• Identity: 306/604 - (50%)
• Similarity: 410/604 - (67%)
• Gaps: 30/604 - (4%)

  Fly     8 LRYDGRVAVVTGAGAGLGREYALLFAERGAKVVVNDLGGTHSGDGASQRAADIVVDEIRKAGGEA 72
            ||:||:|.:|||||.||||||||.|.:|||.|:||||||...|.|.|..|||.||:|||.|||:|
Zfish     5 LRFDGKVVLVTGAGGGLGREYALAFGQRGAAVIVNDLGGDIKGGGKSSAAADKVVEEIRAAGGKA 69

  Fly    73 VADYNSVIDGAKVIETAIKAFGRVDILVNNAGILRDRSLVKTSEQDWNLVNDVHLKGSFKCTQAA 137
            ||:|:||.||.|:|:||:.||||:|::|||||||||||..:||:.||:|:..|||:|||..|:||
Zfish    70 VANYDSVEDGEKLIQTALDAFGRIDVVVNNAGILRDRSFARTSDVDWDLIQRVHLRGSFLVTRAA 134

  Fly   138 FPYMKKQNYGRIIMTSSNSGIYGNFGQVNYTAAKMGLIGLANTVAIEGARNNVLCNVIVPTAASR 202
            :.:||:|.:||||||||.:||||||||.||:|||:||:|||||:||||.:.|:.||.|.|||.||
Zfish   135 WNHMKQQKFGRIIMTSSAAGIYGNFGQANYSAAKLGLLGLANTLAIEGQKYNIHCNTIAPTAGSR 199

  Fly   203 MTEGILPDILFNELKPKLIAPVVAYLCHESCEDNGSYIESAAGWATKLHMVRGKGAVLRPSLDDP 267
            :||.::|..|...||.:.:||:|.:||||||::|....|..|||..||...|..|.::|.. .:.
Zfish   200 LTETVMPPDLVQSLKAEYVAPLVLWLCHESCQENSGLFEVGAGWIGKLRWERSLGRIVRQK-SEC 263

  Fly   268 VTIEYVKDVWSNVTDMSKAKHLGAIAEASGTLLEVLEKLKE----GG-------------GDAIE 315
            ||.|.|:|.|.::.|.:.|....:|.|:..||:|||.::::    |.             |..:.
Zfish   264 VTPEAVRDAWRDICDFTNATKPASIQESLQTLVEVLSRVEDERKIGANPTAVATNPAQAIGHVLP 328

  Fly   316 D-AFEFNSKELITYALGIGASVKNAKDMRFLYENDADFAAIPTFFVLP--GLLLQMSTDKLLSKA 377
            | .|.......|.||||:|.|.::.:.::||||....|:.:|||.|:|  |.||.:.       :
Zfish   329 DMTFTHTHMNCILYALGVGVSSRDPQQLQFLYEGHTHFSCLPTFGVIPAQGALLGLG-------S 386

  Fly   378 LPNSQVDFSNILHGEQYLEIVDDLPTSGTLLTNGKVFDVMDKGSGAVVVTNSESFDESGRLLVRN 442
            :|...:||:.:||||||||:...|||||||.:...|.||:|||||.:::.:..::.|. .||..|
Zfish   387 IPGLDIDFTRLLHGEQYLELYKPLPTSGTLTSRATVADVLDKGSGMLILLDVHTYSEQ-ELLCYN 450

  Fly   443 QSTTFIVGAGKFGGKKDPIAGVVPLQPAPNRQPDATVQYTTSEDQAALYRLSGDKNPLHIDPQMA 507
            |.:.||||:|.||||:.....|.|..| |:|..||.|...||.|||||||||||.|||||||..|
Zfish   451 QFSVFIVGSGGFGGKRVSQKAVAPAAP-PDRPADAVVVEETSRDQAALYRLSGDWNPLHIDPNFA 514

  Fly   508 LLAGFKTPILHGLCTLGFSVRAVLAQFADNNPALFKAVKVRFSGPVIPGQTLRVDLWKQGTRINF 572
            .:.||::|||||||:.||:.|.||.|||.|:.:.|||:||||..||.|||:|:.::||:.:|::.
Zfish   515 AMGGFQSPILHGLCSFGFAARHVLKQFAGNDVSRFKAMKVRFVKPVYPGQSLQTEMWKENSRVHI 579

  Fly   573 RTVVVETGKEVISGAYVDL 591
            :..|.|:|..|:||||:||
Zfish   580 QCTVKESGAVVLSGAYIDL 598

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mfe2	NP_001285318.1	hydroxyacyl-CoA-like_DH_SDR_c-like	8..257	CDD:187611	152/248 (61%)
		PRK07791	11..248	CDD:236099	147/236 (62%)
		PLN02864	315..598	CDD:178455	135/280 (48%)
		hot_dog	<383..442	CDD:294345	28/58 (48%)
		HDE_HSD	471..592	CDD:239532	70/121 (58%)
hsd17b4	XP_021333882.1	hydroxyacyl-CoA-like_DH_SDR_c-like	5..254	CDD:187611	152/248 (61%)
		PLN02864	312..603	CDD:178455	136/296 (46%)
		SCP2	643..744	CDD:307934

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595436
Domainoid	1	1.000	253	1.000	Domainoid score	I2039
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H358
Inparanoid	1	1.050	586	1.000	Inparanoid score	I961
OMA	1	1.010	-	-		QHG51914
OrthoDB	1	1.010	-	-		D1120431at2759
OrthoFinder	1	1.000	-	-		FOG0005261
OrthoInspector	1	1.000	-	-		oto40082
orthoMCL	1	0.900	-	-		OOG6_101391
Panther	1	1.100	-	-	LDO	PTHR13078
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2120
SonicParanoid	1	1.000	-	-		X3784
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.940