DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mfe2 and CG6012

DIOPT Version :9

Sequence 1:	NP_001285318.1	Gene:	Mfe2 / 32582	FlyBaseID:	FBgn0030731	Length:	598	Species:	Drosophila melanogaster
Sequence 2:	NP_609817.1	Gene:	CG6012 / 35022	FlyBaseID:	FBgn0032615	Length:	308	Species:	Drosophila melanogaster

Alignment Length:	318	Identity:	74/318 - (23%)
Similarity:	123/318 - (38%)	Gaps:	92/318 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 KLRY-----------DGRVAVVTGAGAGLGREYALLFAERGAKVVVNDLGGTHSGDGASQRAADI 60
            |:||           .|..|.||||..|:|:|||...|.:...||:         ...::.....
  Fly    33 KIRYFSGTRPTLKERFGDWAAVTGASDGIGKEYAKELARQNINVVL---------IARTEEKLQA 88

  Fly    61 VVDEIRKAGGE-----AVADYNSVIDGAKVIETAIKAFGR--VDILVNNAGILRDRSLVKTSEQD 118
            |..||...|..     .:||:..   |::|.|...|....  :.|||||.||...:||:|.::::
  Fly    89 VAKEIADCGAGVQTKIVIADFTK---GSQVYEHIEKETANIPISILVNNVGIATPKSLLKYNQEE 150

  Fly   119 WNLVNDVHLKGSFKCTQAAFPYMKKQNYGRIIMTSSNSGIYGNFGQVNYTAAKMGLIGLANTVAI 183
            ...:.|.:                      ::..|..|.|:  |.::..:..|..::.:.:...:
  Fly   151 TQNIIDTN----------------------VVAVSQLSRIF--FQRMKASKLKGAIVNVGSGTEL 191

  Fly   184 EGARNNVLCNVIVPTAASRMTEGILPDILFNELKP-----KLIAP--VVAYLCHESCE--DNGSY 239
            :...|...      .|||:.....|...|::|.||     ::::|  ||..:...|.:  ..|..
  Fly   192 QPLPNGAY------YAASKAYTRSLTLALYHEAKPYGIHVQMLSPNFVVTKINSYSRQIMKGGLL 250

  Fly   240 IESAAGWATKLHMVRGKGAV--LRPSLDDPVTIEYVKDVWSNVTDMSKAKHLGAIAEA 295
            |.||:.:|        |.||  ||..:|:  |..|   :|.:|.:        |:|.|
  Fly   251 IPSASAYA--------KSAVNQLRDEVDE--TPGY---LWHHVQN--------AVATA 287

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mfe2	NP_001285318.1	hydroxyacyl-CoA-like_DH_SDR_c-like	8..257	CDD:187611	60/275 (22%)
		PRK07791	11..248	CDD:236099	57/252 (23%)
		PLN02864	315..598	CDD:178455
		hot_dog	<383..442	CDD:294345
		HDE_HSD	471..592	CDD:239532
CG6012	NP_609817.1	17beta-HSD1_like_SDR_c	49..296	CDD:187614	71/302 (24%)
CG6012	NP_609817.1	adh_short	51..243	CDD:278532	52/233 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447668
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840