DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mfe2 and Wwox

DIOPT Version :9

Sequence 1:	NP_001285318.1	Gene:	Mfe2 / 32582	FlyBaseID:	FBgn0030731	Length:	598	Species:	Drosophila melanogaster
Sequence 2:	NP_001285735.1	Gene:	Wwox / 34090	FlyBaseID:	FBgn0031972	Length:	409	Species:	Drosophila melanogaster

Alignment Length:	207	Identity:	51/207 - (24%)
Similarity:	82/207 - (39%)	Gaps:	53/207 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 GRVAVVTGAGAGLGREYALLFAERGAKVVVNDLGGTHSGDGASQRAADIVVDEIRKAGGE----A 72
            ||.|::|||..|:|.|.|...|..|.:::. ......|.:.|.:|.|     :.|.|...    |
  Fly   121 GRTALITGANCGIGYETARSLAHHGCEIIF-ACRNRSSAEAAIERIA-----QERPAARSRCRFA 179

  Fly    73 VADYNSVIDGAKVIETAIKAFGRVDILVNNAGILRDRSLVKTSEQDWNLVNDVHLKGSFKCTQAA 137
            ..|.:|:....:.:|...::...:|.|:.|||:.   :|..|...|       .|:.:|:.:..:
  Fly   180 ALDLSSLRSVQRFVEEIKQSVSHIDYLILNAGVF---ALPYTRTVD-------GLETTFQVSHLS 234

  Fly   138 FPYMKKQ-----NY-GRIIMTSSNSGIYGNFGQVNYTAAKMGLIGLANTVAIEG----------- 185
            ..|:..|     :| .|||:.||.|..:.|....|              :|:..
  Fly   235 HFYLTLQLETLFDYKTRIIVLSSESHRFANLPVEN--------------LAVHHLSPPPEKYWSM 285

  Fly   186 -ARNNV-LCNVI 195
             |.||. ||||:
  Fly   286 MAYNNAKLCNVL 297

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mfe2	NP_001285318.1	hydroxyacyl-CoA-like_DH_SDR_c-like	8..257	CDD:187611	51/207 (25%)
		PRK07791	11..248	CDD:236099	51/207 (25%)
		PLN02864	315..598	CDD:178455
		hot_dog	<383..442	CDD:294345
		HDE_HSD	471..592	CDD:239532
Wwox	NP_001285735.1	WW	13..43	CDD:197736
		WW	54..86	CDD:197736
		PRK06196	104..402	CDD:235736	51/207 (25%)
		human_WWOX_like_SDR_c-like	121..402	CDD:187669	51/207 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447669
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930