DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mfe2 and CG30495

DIOPT Version :9

Sequence 1:	NP_001285318.1	Gene:	Mfe2 / 32582	FlyBaseID:	FBgn0030731	Length:	598	Species:	Drosophila melanogaster
Sequence 2:	NP_001260785.1	Gene:	CG30495 / 246651	FlyBaseID:	FBgn0050495	Length:	331	Species:	Drosophila melanogaster

Alignment Length:	332	Identity:	76/332 - (22%)
Similarity:	123/332 - (37%)	Gaps:	90/332 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 GKLRYD----GRVAVVTGAGAGLGREYALLFAERGAKVVVNDLGGTHSGDGASQRAADIVVDEIR 66
            ||.|..    |:||:|||...|||:|..:..|.|||.|.:    ...:.:...:...:||    :
  Fly    35 GKFRKQTDETGKVAIVTGGNTGLGKETVMELARRGATVYM----ACRNKEKVERARREIV----K 91

  Fly    67 KAGGEAV----ADYNSVIDGAKVIETAIKAFGRVDILVNNAGILRDRSLVKTSEQDWNL-VNDVH 126
            :.|...|    .|.:|:....|..|...|....:.||:||||:..:...:.....:.:| ||.:
  Fly    92 ETGNSNVFSRECDLSSLDSIRKFAENFKKEQRVLHILINNAGVFWEPHRLTKEGFEMHLGVNHI- 155

  Fly   127 LKGSFKCTQAAFPYMKKQNYGRIIMTSS-------------NSGIYGNFGQVNYTAAKMGLI--- 175
              |.|..|......:::....|:::.:|             ||..:.:.| |.|..:|:..|
  Fly   156 --GHFLLTNLLLGVLERSAPSRVVVVASRAHERGQIKVDDINSSDFYDEG-VAYCQSKLANILFT 217

  Fly   176 -------------------GLANTVAIEGARNNVLCNVIVPTAASRMTEGILPDILFNELK-PKL 220
                               |:|:|   |.|||.:....   ..|..:.|.||..:|:..:| ||
  Fly   218 RELAKRLEGTGVTVNALNPGIADT---EIARNMIFFQT---KFAQYVVETILRPLLWAVMKTPK- 275

  Fly   221 IAPVVAYLCHESCEDNGSYIESAAGWATKLHMVRGK---GAVLRP----SLDDPVTIEYVKDVWS 278
                           ||:.....|.....|..|.|:   ...|.|    :|||    :..:.:|:
  Fly   276 ---------------NGAQTTLYAALDPDLERVSGQYFSDCALAPVAPAALDD----QMAQWLWA 321

  Fly   279 NVTDMSK 285
            .....:|
  Fly   322 QSEKWAK 328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mfe2	NP_001285318.1	hydroxyacyl-CoA-like_DH_SDR_c-like	8..257	CDD:187611	67/296 (23%)
		PRK07791	11..248	CDD:236099	63/281 (22%)
		PLN02864	315..598	CDD:178455
		hot_dog	<383..442	CDD:294345
		HDE_HSD	471..592	CDD:239532
CG30495	NP_001260785.1	FabG	44..296	CDD:223959	65/285 (23%)
CG30495	NP_001260785.1	NADB_Rossmann	45..323	CDD:304358	72/315 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447671
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930