DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kat80 and HAT2

DIOPT Version :9

Sequence 1:	NP_523363.2	Gene:	kat80 / 32581	FlyBaseID:	FBgn0040207	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_010858.3	Gene:	HAT2 / 856654	SGDID:	S000000782	Length:	401	Species:	Saccharomyces cerevisiae

Alignment Length:	295	Identity:	74/295 - (25%)
Similarity:	118/295 - (40%)	Gaps:	45/295 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 GEDRNVNLWAIGQNECFMSLTGHNRSIDCVRFAYKD-NFVYSADDIGIIRRWDLNSQKIYSTLNG 100
            ||:...:|.|...|....:...|...|...|:..:| |.|.:.:..|.:..:. .|:.:.|||..
Yeast    95 GEEYQSSLPAPRSNIRITAKYEHEEEITRARYMPQDPNIVATINGQGTVFLYS-RSEGLQSTLKF 158

  Fly   101 HMKSVRTLDFNP--SGEYVVSGSNDTTVRLWDVQNENNCIKVCRG----HMSHVNSVK---FSPD 156
            |..:...|.|:.  .|. ::|||:|.||.||:|.:..:..|..|.    |...:|..|   |:.|
Yeast   159 HKDNGYALSFSTLVKGR-LLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKD 222

  Fly   157 GLWIASAGLEGSIL-IWDIRKSKQIMEFIADPPVTAITCVQFHPFEFLLAAGRVDGTVSIYDLEH 220
            .....|   |.|:| |.|:|.:...::.:..|..........|....|.||| :|..|.:|||.:
Yeast   223 LFGTVS---EDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAG-MDSYVYLYDLRN 283

  Fly   221 QQLVSQTTHFYG--QAIRCITFSDNGECLFVGSSSGISVIGWE---------PDRELDHIKSTWS 274
            .:  ....|..|  .|:..:.||.:.:.:.|.|.|...::.|:         ||...|.:.
Yeast   284 MK--EPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVP---- 342

  Fly   275 SLADMKVVNNKLICGCHEIDTVSINTISLDRVIPF 309
                      :||. .|.....|:|...|:..||:
Yeast   343 ----------ELIM-VHAGHRSSVNDFDLNPQIPW 366

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kat80	NP_523363.2	Katanin_con80	667..803	CDD:290636
		WD40	<4..330	CDD:225201	74/295 (25%)
		WD40	14..260	CDD:238121	62/235 (26%)
		WD40 repeat	22..58	CDD:293791	5/20 (25%)
		WD40 repeat	63..99	CDD:293791	9/36 (25%)
		WD40 repeat	106..142	CDD:293791	13/37 (35%)
		WD40 repeat	148..184	CDD:293791	11/39 (28%)
		WD40 repeat	192..228	CDD:293791	10/35 (29%)
		WD40 repeat	285..310	CDD:293791	8/25 (32%)
HAT2	NP_010858.3	CAF1C_H4-bd	12..82	CDD:403473
		WD40	<116..401	CDD:225201	69/274 (25%)
		WD40 repeat	122..158	CDD:293791	9/36 (25%)
		WD40 repeat	163..204	CDD:293791	14/41 (34%)
		WD40 repeat	212..247	CDD:293791	11/37 (30%)
		WD40 repeat	254..292	CDD:293791	11/40 (28%)
		WD40 repeat	298..349	CDD:293791	11/65 (17%)
		WD40 repeat	355..380	CDD:293791	4/12 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910