DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kat80 and CIA1

DIOPT Version :9

Sequence 1:	NP_523363.2	Gene:	kat80 / 32581	FlyBaseID:	FBgn0040207	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_010553.3	Gene:	CIA1 / 851860	SGDID:	S000002675	Length:	330	Species:	Saccharomyces cerevisiae

Alignment Length:	299	Identity:	65/299 - (21%)
Similarity:	112/299 - (37%)	Gaps:	85/299 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 ISKIYDIKAHDSRVTSLDLGETGRVLVTGGEDRNVNLWAIGQNECFMSLTGHNRSIDCVRFAYKD 72
            |:.|..:|.:..::.|.|..:  .:|.||..||.:.|.::
Yeast     4 INLIKSLKLYKEKIWSFDFSQ--GILATGSTDRKIKLVSV------------------------- 41

  Fly    73 NFVYSADDIGIIRRWDLNSQKIYSTLNGHMKSVRTLDFNPSGEYVVSGSNDTTVRLW------DV 131
                ..||..:|...|..:         |.|::|::.:.|....:.:||.|:||.:|      |.
Yeast    42 ----KYDDFTLIDVLDETA---------HKKAIRSVAWRPHTSLLAAGSFDSTVSIWAKEESADR 93

  Fly   132 QNENNCIKVCRGHMSHVNSVKFSPDGLWIASAGLEGSILIWDIRKSKQIMEFIA--DPPVTAITC 194
            ..|.:.:.:..||.:.|..|.:|.||.::|:...:.|:.||:..:|.:..|.|:  ......:..
Yeast    94 TFEMDLLAIIEGHENEVKGVAWSNDGYYLATCSRDKSVWIWETDESGEEYECISVLQEHSQDVKH 158

  Fly   195 VQFHPFEFLLAAGRVDGTVSIYDLEHQQLVSQTTHFYGQAIRCITFSDNGECLFVGSSSGISVIG 259
            |.:||.|.|||:...|.||.|:.                     .:.|:.||:.|.:.
Yeast   159 VIWHPSEALLASSSYDDTVRIWK---------------------DYDDDWECVAVLNG------- 195

  Fly   260 WEPDRELDHIKSTWSSLADMKVVNNKLICGCHEIDTVSI 298
                    |..:.|||..| |......:|...:..||.:
Yeast   196 --------HEGTVWSSDFD-KTEGVFRLCSGSDDSTVRV 225

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kat80	NP_523363.2	Katanin_con80	667..803	CDD:290636
		WD40	<4..330	CDD:225201	65/299 (22%)
		WD40	14..260	CDD:238121	54/253 (21%)
		WD40 repeat	22..58	CDD:293791	8/35 (23%)
		WD40 repeat	63..99	CDD:293791	4/35 (11%)
		WD40 repeat	106..142	CDD:293791	10/41 (24%)
		WD40 repeat	148..184	CDD:293791	11/35 (31%)
		WD40 repeat	192..228	CDD:293791	11/35 (31%)
		WD40 repeat	285..310	CDD:293791	3/14 (21%)
CIA1	NP_010553.3	WD40	6..325	CDD:238121	64/297 (22%)
		WD40 repeat	17..54	CDD:293791	11/67 (16%)
		WD40 repeat	63..105	CDD:293791	9/41 (22%)
		WD40 repeat	111..151	CDD:293791	11/39 (28%)
		WD40 repeat	156..194	CDD:293791	15/58 (26%)
		WD40 repeat	201..246	CDD:293791	8/26 (31%)
		WD40 repeat	253..289	CDD:293791
		WD40 repeat	298..326	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910